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Near infrared spectrum damage-free analysis method for anti-tuberculosis drugs

A near-infrared spectroscopy and non-destructive analysis technology, applied in the field of drug detection and analysis, can solve the problems of cumbersome and time-consuming anti-tuberculosis drug detection operations, and achieve the effects of small error, reliable results, and accurate and reliable results

Inactive Publication Date: 2008-01-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] The invention discloses a method for non-destructive analysis of anti-tuberculosis drugs by near-infrared spectroscopy. The sample does not need pretreatment, and high-throughput, online non-destructive analysis can be realized. The result is accurate and reliable, and the error is less than 5%, which solves the existing detection operation of anti-tuberculosis drugs cumbersome and time-consuming issues

Method used

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  • Near infrared spectrum damage-free analysis method for anti-tuberculosis drugs
  • Near infrared spectrum damage-free analysis method for anti-tuberculosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Determination of the content of rifampicin in rifampin tablets:

[0029] collect inner mongolia ** 50 rifampicin tablets from the pharmaceutical industry were used as samples to be tested, product batch number: 031123. A total of 236 samples of five anti-tuberculosis drugs, rifampicin, isoniazid, pyrazinamide, isoferamide and isoferamide, were used as modeling samples.

[0030] The sample was pulverized and dissolved, and the content of the active ingredient rifampicin in the rifampicin tablets was measured by high performance liquid chromatography.

[0031] Embed the rifampicin tablet sample in the center of the blank plate, put it in the sample tank of the integrating sphere of the near-infrared spectrum detector, use the spectral wavelength of 1500-2000nm through model analysis, and select the spectral passband width as 12nm, and record each sample in the near-infrared spectral region. the absorption spectrum. see picture 1.

[0032] A mathematical model of the r...

Embodiment 2

[0037] Determination of the content of isoniazid in isoniazid tablets:

[0038] collect chengdu ** 40 pieces of isoniazid tablets from the pharmaceutical industry were used as samples to be tested, product batch number: 041005. A total of 236 samples of five anti-tuberculosis drugs, rifampicin, isoniazid, pyrazinamide, isoferamide and isoferamide, were used as modeling samples.

[0039] The samples were pulverized and dissolved, and the content of the active ingredient isoniazid in the isoniazid tablets was measured by high performance liquid chromatography.

[0040] Embed the sample of isoniazid tablet in the center of the blank plate, put it in the sample tank of the integrating sphere of the near-infrared spectrum detector, use the spectral wavelength of 1500-2000nm through model analysis, and select the spectral passband width as 12nm, and record each sample in the near-infrared spectral region. the absorption spectrum. see picture 1.

[0041] Using the partial least s...

Embodiment 3

[0046] Determination of rifampicin, isoniazid and pyrazinamide content in isofamide:

[0047] Collect North China Pharmaceutical ** 48 Isofer tablets of Co., Ltd. were used as samples to be tested, and five anti-tuberculosis drugs, Rifampicin, Isoniazid, Pyrazinamide, Isofia and Isofamide, were used as construction samples, with a total of 236 samples. Mold samples.

[0048] The samples were pulverized and dissolved, and the contents of rifampicin, isoniazid and pyrazinamide, the active ingredients in isofamide, were measured by HPLC.

[0049] Embed the ifofamide sample in the center of the blank plate, put it in the sample tank of the integrating sphere of the near-infrared spectrum detector, use the spectral wavelength of 1300-2500nm through model analysis, and select the spectral passband width as 12nm, and record the concentration of each sample in the near-infrared spectral region. absorption spectrum. see picture 1.

[0050] The mathematical model of the relationship...

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Abstract

The invention discloses method of testing effective constituent of near infrared light detection anti tubercular agent. Using the basis of anti tubercular agent action spectrum near infrared light and the measurand information, getting effective constituent (rifampicin,isoniazide or pyrazinamide ) of which by anti tubercular agent action spectrum near infrared light and their background information; achieving the lossless detection the content of effective constituent (rifampicin,isoniazide or pyrazinamide ) in the anti tubercular agent near infrared light complex background by the multi element normalized method of chemometrics. It settles the problem of high cost, long period, medicament cannot use after analyzing etc when analyzing the anti tubercular agent effective constituent in existence, establishing the fast, high pass mete, lossless and needed on-line analysis green medicament analytic method for the anti tubercular agent. The advantages is that the sample pre-processing is easy, the detection is fast and undamaged, the detection time of each sample is shortage of two min; the result is credibility, the error is less than5%.

Description

technical field [0001] The invention discloses a method for non-destructive analysis of anti-tuberculosis drugs by near-infrared spectroscopy, relates to rapid non-destructive detection of the content of active ingredients in anti-tuberculosis drugs, and belongs to the technical field of drug detection and analysis. Background technique [0002] Tuberculosis is one of the main causes of death from a single infection. There are 8 to 10 million new cases each year, and 2 to 3 million deaths due to tuberculosis each year. Tuberculosis causes more deaths among young people than any infectious disease. Rifampicin, isoniazid and pyrazinamide are relatively effective drugs against tuberculosis at present. [0003] At present, the ingredients and background of anti-tuberculosis drugs are complex, and the conventional determination methods of active ingredients rifampicin, isoniazid and pyrazinamide need to separate and measure the ingredients of the sample, such as reversed-phase hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/35G01N33/15G06F17/00G01N21/3563G01N21/359
Inventor 滕乐生王迪滕利荣孟庆繁逯家辉张益波郭伟良蒋朝军
Owner JILIN UNIV
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