Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel hydrochloric acid tramadol sustained-release tablet and preparation method

A technology of tramadol hydrochloride and slow-release tablets, which is applied in the field of medicine, can solve the problem of stable effective blood drug concentration not changing, and achieve the effects of maintaining blood drug concentration, increasing bioavailability, and improving stability

Active Publication Date: 2010-10-06
CSPC OUYI PHARM CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention solves the problems existing in the current prior art, and provides a slow-release tablet that releases tramadol hydrochloride for a long time and can be administered at a relatively long interval of time, and the steady-state effective blood drug concentration of tramadol is almost unchanged agent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel hydrochloric acid tramadol sustained-release tablet and preparation method
  • Novel hydrochloric acid tramadol sustained-release tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1000 tablets, the specification is 90mg.

[0024] prescription:

[0025] Tablet core Film coating

[0026] Tramadol Hydrochloride 90g Hydroxypropyl Methylcellulose 3g

[0027] Chitosan 135g Talc 2g

[0028] Lactose 17.9g Stearic acid 0.5g

[0029] Polyvinylpyrrolidone 5.36g Ethanol 100ml

[0030] Magnesium stearate 1.78g

[0031] Glyceryl monostearate 22.5g

[0032] Proper amount of ethanol

[0033] Preparation:

[0034] a. Preparation of tablet core: Take the prescribed amount of slow-release material, add distilled water, stir in a hot water bath at 70°C to 80°C, take it out after dissolving, quickly emulsify with tramadol hydrochloride, add monostearic acid under constant stirring Glyceride until mixed evenly, adjust the pH value to 5.0-6.0 with 10% hydrochloric acid solution, add distilled water to continue stirring, then place in a cold water bath to cool, add 36% formaldehyde solution and stir for 10min-15min, adjust with 10% sodium hydroxide solution W...

Embodiment 2

[0037] 1000 tablets, the specification is 100mg.

[0038] prescription:

[0039] Tablet core Film coating

[0040] Tramadol Hydrochloride 100g Hydroxypropyl Methylcellulose 4.5g

[0041] Xanthan Gum 140g Talc 3g

[0042] Lactose 30.25g Stearic acid 0.75g

[0043] Polyvinylpyrrolidone 9.08g Ethanol 150ml

[0044] Magnesium stearate 3.03g

[0045] Glyceryl monostearate 24g

[0046] Proper amount of ethanol

[0047] The preparation method is the same as in Example 1.

Embodiment 3

[0049] 1000 tablets, the specification is 110mg.

[0050] prescription:

[0051] Tablet core Film coating

[0052] Tramadol Hydrochloride 110g Hydroxypropyl Methylcellulose 6g

[0053] Chitosan 143g Talc 4g

[0054] Lactose 45.2g Stearic acid 1g

[0055] Polyvinylpyrrolidone 13.56g Ethanol 200ml

[0056] Magnesium stearate 4.52g

[0057] Glyceryl monostearate 25.3g

[0058] Proper amount of ethanol

[0059] The preparation method is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a new type sustained release tablets of tramadol hydrochloride and the preparation method. The sustained release tablets comprise tablet core and membrane clothing sheet. The tablet core contains sustained release capsule of tramadol hydrochloride with its weight being 80-90% of total weight of tablet core, and the sustained release capsule is prepared with tramadol hydrochloride and sustained release material with ratio being 1: 1.2-1.5. The sustained release capsule also contains 10% monoglyceride. The sustained release tablet is characterized by stable effective blood concentration, increased biological utilization rate, reduced side effect, good taste and small intake amount of one time per day.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation, in particular to a preparation method of a novel sustained-release tablet with tramadol or a salt thereof as an active ingredient, and belongs to the technical field of medicine. Background technique [0002] Tramadol is a centrally acting analgesic with a dual mechanism of analgesia, that is, by stimulating the opioid μ receptor and inhibiting the reuptake of central monoaminergic substances (serotonin and norepinephrine). It exerts analgesic effect, and has the characteristics of strong analgesic effect, low drug dependence, low abuse potential, and no typical side effects of many opioid agonists. [0003] Tramadol has a relatively short half-life, so multiple administrations are required. However, in order to maintain an effective amount of blood drug concentration and achieve therapeutic effects, the initial overdose at the initial stage of administration may cause more ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61K9/22A61K9/36A61K9/52A61K47/32
Inventor 郭卫芹张育李国聪王晨光韩婷
Owner CSPC OUYI PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com