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Aerosol of brain peptide and preparation method

An aerosol and solvent technology, applied in the field of brain peptide aerosol and its preparation, can solve the problem of few reports, and achieve the effects of consistent bioavailability, high bioavailability, and fast absorption and utilization

Inactive Publication Date: 2007-12-26
SHANGHAI CAS INTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The research and application of peptides affecting memory are widely used in medicine and other fields, but there are few related reports

Method used

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  • Aerosol of brain peptide and preparation method
  • Aerosol of brain peptide and preparation method
  • Aerosol of brain peptide and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Weigh 1 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;

[0061] (2) Take 0.15 mg of the memory enhancing peptide, add 1000 ml of sterile distilled water, and stir to dissolve;

[0062] (3) Take 140 ml of the solubilizing agent, add the solution obtained in (2), and stir evenly;

[0063] (4) Mix the solution obtained in (1) with the solution obtained in (3), and add sterile distilled water until the solution is 5000ml, and then stir evenly;

[0064] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;

[0065] (6) Divide the solution obtained in (5) into a sprayer, each with 5ml, and get 1000 bottles.

[0066] Specification: 0.150mg (calculated as anhydrous and acetate) / 5ml / bottle.

Embodiment 2

[0068] (1) Weigh 2 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;

[0069] (2) Take 0.300g of the memory enhancing peptide, add 1000ml of sterile distilled water, stir to dissolve;

[0070](3) Take 250ml of the solubilizing agent glycerin, add to the solution obtained in (2), and stir evenly;

[0071] (4) Mix the solution obtained in (1) with the solution obtained in (3), add sterile distilled water to 5000ml, and then stir evenly;

[0072] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;

[0073] (6) Divide the solution obtained in (5) into a sprayer, each bottle of 5ml, that is, 1000 bottles.

[0074] Specification: 0.300mg (calculated as anhydrous and acetate) / 5ml / bottle.

Embodiment 3

[0076] (1) Weigh 4.5 g of the bacteriostatic agent ethyl p-hydroxybenzoate, add 3000 ml of sterile distilled water, and heat to dissolve;

[0077] (2) Take 0.15 mg of the memory enhancing peptide, add 1000 ml of sterile distilled water, and stir to dissolve;

[0078] (3) Take 360ml of the solubilizer, add the solution obtained in (2), and stir evenly;

[0079] (4) Mix the solution obtained in (1) with the solution obtained in (3), and add sterile distilled water until the solution is 5000ml, and then stir evenly;

[0080] (5) Adjust the pH of the solution obtained in (4) to 4.5-6.5 with 1mol / L HCl and 1mol / L naOH solution;

[0081] (6) Divide the solution obtained in (5) into a sprayer, each with 5ml, and get 1000 bottles.

[0082] Specification: 0.450mg (calculated as anhydrous and acetate) / 5ml / bottle

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Abstract

The present invention relates to a cerebropeptide aerosol and its preparation method, belonging to the field of medicine preparation technology. Said preparation is made up by using (by weight portion) 1.5-4.5 portions of hypermnesia peptide and 25000-75000 portions of water through a certain preparation method. Said invention can be used for nasal medication, and can obtain the effect of raising memory and comprehension ability. Said invention also provides the concrete steps of its preparation method.

Description

Technical field [0001] The invention relates to a brain peptide aerosol and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] The research and application of peptides that affect memory are widely used in medicine and other fields, but there are few related reports. [0003] Chinese invention patent 93112493.X (Memory Enhancement Peptide and Its Application) discloses a synthetic polypeptide that can promote learning and memory functions, namely Memory Enhancement Peptide (MEP). After chemical simulation design, molecular dynamics calculation and combined synthetic peptide activity kinetic energy measurement, the synthetic peptide can be made into various forms of medicines and beverages for health care or treatment of learning and memory disorders, such as promoting early brain development and strengthening adulthood Learning memory and treatment of senile dementia, etc. [0004] Chinese invention patent 00116876...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K38/07A61K38/08A61P25/28
Inventor 杜雨苍
Owner SHANGHAI CAS INTIDE BIOTECH
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