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Anti-infectious compound andrographis preparation and its preparation technology

A compound preparation and anti-infection technology, which can be used in medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc., can solve problems such as drug-resistant infections, antibiotics cannot meet clinical needs, etc., to achieve stable quality, easy quality control, The effect of high safety

Inactive Publication Date: 2007-12-12
朱志宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, due to the long-term and extensive use of antibiotics, the drug resistance of bacteria has been continuously enhanced, and the frequency of drug resistance has gradually increased, resulting in problems that conventional antibiotics cannot meet clinical needs. At present, the widespread emergence of bacterial drug resistance and Drug-resistant infection has become a major problem in Western medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 25g of andrographolide and 16g of houttuyfonate sodium were weighed respectively, mixed evenly, and corresponding auxiliary materials such as sucrose, starch, microcrystalline cellulose, etc. were added to prepare 1000 tablets.

Embodiment 2

[0019] Andrographis paniculata was weighed to extract, and 30 g of houttuyonin sodium was weighed to prepare capsules as follows: A. Extract Andrographis paniculata with water twice. Add 10 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 1 hour, combine the extracts, filter, and concentrate the filtrate to a concentrate equivalent to 3g of the original medicinal material per gram for use. B. Weigh 90g of the concentrated solution obtained in A, dry, pulverize and grind it into powder, mix it with houttuyfonate sodium, and add the corresponding auxiliary materials starch, magnesium stearate, sodium lauryl sulfate, hydroxypropyl methylcellulose etc., granulating, sizing, mixing, drying, and filling into gelatin capsules. Prepare 1000 capsules.

Embodiment 3

[0021] Weigh 1 g of houttuyfonate sodium and 1.5 g of andrographolide, respectively. Take 20ml of water for injection, add about 8g of sodium chloride, then add houttuyfonate sodium and andrographolide to dissolve it, add an appropriate amount of polysorbate, adjust the pH to 5.0-5.5 with 0.1mol / L sodium carbonate, and then add water To 1000ml, stir well, filter and pack in neutral glass containers, and sterilize with circulating steam at 100°C for 45 minutes.

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PUM

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Abstract

The invention relates to a traditional Chinese anti-infective composition and process for preparation, wherein the composition is prepared from one of green chiretta and green chiretta active constituent of andrographolide (any one of the derivative containing andrographolide), one of houttuynia cordata and houttuynia cordata active constituent of houttuyninum (including its sodium salts), and one or more medicinal auxiliary materials. The invention also provides a process for preparing the anti-infective composition.

Description

field of invention [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for antibacterial and anti-inflammation and a production process thereof, in particular to one of the traditional Chinese medicine Andrographis paniculata or its active ingredient andrographolide (derivatives containing andrographolide) and Houttuynia cordata or its active ingredient andrographolide. The active ingredient houttuyniatin (sodium salt containing houttuyniatin) is a combination of one and two main ingredients, and is used to treat various infectious diseases such as respiratory tract infection, bacillary dysentery, gastroenteritis, and urethritis. Background technique [0002] With the continuous production of various antibacterial drugs represented by penicillin, bacterial infectious diseases that once made human beings helpless have been effectively controlled, thus antibiotics have become a powerful weapon in human hands against pathogenic b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K36/19A61K9/08A61K9/10A61K9/20A61K9/48A61P11/00A61P1/12A61P13/02A61P31/04A61K31/365A61K31/121
Inventor 朱志宏
Owner 朱志宏
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