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Protease inhibitors liposomes aerosol

A technology of protease inhibitors and gas, applied in the field of new applications of protease inhibitors

Inactive Publication Date: 2007-12-05
王继峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of protease inhibitors and liposome aerosol formulations to treat acute lung injury, acute respiratory failure distress and pulmonary fibrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: BBI liposome aerosol treats alveolitis

[0074] [Prescription] BBI250mg, lecithin 500mg, cholesterol 250mg, vitamin E 50mg, propellant 12 12.5mg, phosphate buffer solution (Ph7.2) 50ml, ether 15ml.

[0075] [Preparation method] Weigh BBI, lecithin, cholesterol and vitamin E according to the prescription amount, and dissolve them completely in 15ml ether solution. Use a rotary evaporator to pump out the residual ether solution, and make the solute form a uniform film on the inner wall of the container. Slowly pour the phosphate buffer solution (pH7.2) into the container with the solute film attached, and use an ultrasonic pulverizer to fully shake and stir the solution until the solute and the phosphate buffer solution form a uniform suspension. Add the propellant according to the prescription amount and mix well. Add the solution to a compressed atomizing inhaler for atomization, 200mg to 500mg / day.

Embodiment 2

[0076] Embodiment 2: PMSF liposome aerosol treats acute pulmonary failure

[0077] 【Prescription】PMSF250mg, lecithin 500mg, cholesterol 250mg, vitamin E 50mg, propellant 12 12.5mg, phosphate buffer solution (Ph7.2) 50ml, ether 15ml.

[0078] [Preparation method] Weigh PMSF, lecithin, cholesterol and vitamin E according to the prescription amount, and dissolve them completely in 15ml ether solution. Use a rotary evaporator to pump out the residual ether solution, and make the solute form a uniform film on the inner wall of the container. Slowly pour the phosphate buffer solution (pH7.2) into the container with the solute film attached, and use an ultrasonic pulverizer to fully shake and stir the solution until the solute and the phosphate buffer solution form a uniform suspension. Add the propellant according to the prescription amount and mix well. Add the solution to a compressed atomizing inhaler for atomization, 200mg to 500mg / day.

Embodiment 3

[0079] Embodiment 3: AP liposome aerosol treats pulmonary fibrosis

[0080] [Prescription] AP250mg, lecithin 500mg, cholesterol 250mg, vitamin E 50mg, propellant 12 12.5mg, phosphate buffer solution (Ph7.2) 50ml, ether 15ml.

[0081] [Preparation method] Weigh AP, lecithin, cholesterol, and vitamin E according to the prescription amount, and dissolve them completely in 15ml ether solution. Use a rotary evaporator to pump out the residual ether solution, and make the solute form a uniform film on the inner wall of the container. Slowly pour the phosphate buffer solution (pH7.2) into the container with the solute film attached, and use an ultrasonic pulverizer to fully shake and stir the solution until the solute and the phosphate buffer solution form a uniform suspension. Add the propellant according to the prescription amount and mix well. Add the solution to a compressed nebulizer inhaler for nebulization.

[0082] Lecithin in the above embodiment, cholesterol, vitamin E...

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PUM

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Abstract

The present invention discloses one kind of liposome aerosol with protease inhibitor for preventing and treating alveolitis and pulmonary interstitial fibrosis. The liposome aerosol of the present invention is prepared with protease inhibitor, lecithin, cholesterol, vitamin E, ether and other ingredients, and through rotary evaporation, ultrasonic crushing, vibrating stirring, compression atomizing and other steps.

Description

[0001] The patent application of the present invention is a divisional application, the original application number is 03156753.3, the application date is September 9, 2003, and the title of the invention is the new use of protease inhibitors for preventing and treating lung diseases. technical field [0002] The invention relates to a new application of a medicine, in particular to a new application of protease inhibitors. Background technique [0003] Protease inhibitors are the prevention and treatment of various thrombosis, disseminated intravascular coagulation, inflammatory diseases (pancreatitis, allergic conjunctivitis, rhinitis, rheumatoid arthritis, nephritis, etc.), inhibition of tumor cell growth and infiltration, autoimmune (Asthma) and related diseases. However, there is no report on the use of protease inhibitors and liposome aerosol formulations to treat pulmonary diseases such as acute lung injury, acute respiratory failure distress and pulmonary fibrosis. ...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/255A61K38/55A61K45/06A61P11/00
Inventor 王继峰牛建昭付敏段斐孔璐张东伟李健韦燕飞乔晨
Owner 王继峰
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