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Pancreatic kininogenase tablet and preparing method

A technology of pancreatic kininogenase and tablets, which is applied in the field of pancreatic kininogenase tablets and its preparation, and can solve problems such as unstable drug quality

Active Publication Date: 2007-11-14
上海丽珠制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing pancreatic kininogenase preparations, especially tablets, often lead to unstable drug quality due to the problem of encapsulation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] formula

[0019] Name of raw material

Fineness

100,000 tablets

Pancreatic kininogenase

80 mesh

15 million units

lactose

80 mesh

8.0kg

microcrystalline cellulose

80 mesh

2.7kg

10% dextrin + 20% sucrose mixed binder

80 mesh

about 7.6kg

Magnesium stearate

80 mesh

0.10kg

Carboxymethyl Starch Sodium

80 mesh

0.5kg

Film coating premix (930 Opadry)

——

1.925kg

[0020] Ouba purchased from Shaoxing Pingyu Biotechnology Co., Ltd.

[0021] Preparation

[0022] Sieving: pass the dextrin, microcrystalline cellulose, lactose, magnesium stearate and sodium carboxymethyl starch described in the above formula through a 80-mesh sieve.

[0023] Adhesive preparation (based on the preparation of 40.0kg): Accurately weigh 8.0kg of sucrose into a stainless steel bucket, add 8kg of hot purified water, stir to dissolve it; accurately weigh 4.0kg of dextrin into a...

Embodiment 2

[0031] formula

[0032] Name of raw material

Fineness

100,000 tablets

Pancreatic kininogenase

80 mesh

5 million units

lactose

80 mesh

5kg

microcrystalline cellulose

80 mesh

4kg

[0033] 10% dextrin + 20% sucrose mixed binder

80 mesh

10kg

Magnesium stearate

80 mesh

0.1kg

Carboxymethyl Starch Sodium

80 mesh

0.1kg

Film coating premix (Xinjiecai)

——

0.5kg

[0034] Preparation

[0035] According to the method similar to that described in the above-mentioned Example 1, the film-coated tablet was made according to the above-mentioned formula.

Embodiment 3

[0037] formula

[0038] Name of raw material

Fineness

100,000 tablets

Pancreatic kininogenase

80 mesh

8 million units

lactose

80 mesh

10kg

microcrystalline cellulose

80 mesh

1kg

10% dextrin + 20% sucrose mixed binder

80 mesh

3kg

Magnesium stearate

80 mesh

0.5kg

Carboxymethyl Starch Sodium

80 mesh

0.5kg

Film coating premix (Jicai)

——

5kg

[0039] Preparation

[0040] According to the method similar to that described in the above-mentioned Example 1, the film-coated tablet was made according to the above-mentioned formula.

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PUM

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Abstract

The present invention relates to a kallidinogenase tablet preparation and its preparation method. In the invented kallidinogenase tablet preparation the kallidinogenase is contained, and is used as active component, and in its tablet core the hydroxymethyl starch sodium is contained and can be used as disintegrant.

Description

technical field [0001] The invention relates to a pancreatic kininogenase tablet and a preparation method thereof. Background technique [0002] Pancreatic kininogenase is a vasodilator that can improve microcirculation. It is mainly used to treat microcirculation disorders, such as nephropathy caused by diabetes, peripheral neuropathy, retinopathy, fundus disease and ischemic cerebrovascular disease. It can be used as an adjuvant therapy for hypertension. [0003] Pancreatic kininogenase has the functions of dilating blood vessels and improving microcirculation; activating plasmin, reducing blood viscosity; inhibiting phospholipase A2, preventing platelet aggregation, and preventing thrombosis. [0004] Pancreatic kininogenase can be prepared into various preparation forms according to conventional preparation methods for clinical use. However, the existing pancreatic kininogenase preparations, especially tablets, often lead to unstable drug quality due to the problem of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/20A61K47/36A61P3/10A61P9/10A61P9/12A61P13/12A61P25/02A61P27/02
Inventor 王乘炜庄志红邵红军陈一平
Owner 上海丽珠制药有限公司
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