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Medicine carrying aquogel matrix for preparing plaster and its prepn process

A hydrogel and drug-loading technology, which is applied in the field of new transdermal drug delivery preparations, can solve problems that affect popularization and application, fail to meet technical requirements, and cannot be promoted well, and achieve smooth appearance and good product formability , neat edge effect

Active Publication Date: 2007-11-07
广东新时代新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in our country, the gel is still in the development stage. It was mainly used as a hospital preparation in the early days, and it was used in dermatology, surgery, etc., but it did not meet the technical requirements and could not be popularized.
There are not many gels on the market in China. The main reason is that there are still few gel matrix materials used in the research and application of gels, which seriously affects the popularization and application of this dosage form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Take 60 parts of deionized water, 0.001 part of disodium edetate, 0.01 part of Tween 80, mix well, stir at low speed, add 1 part of Carbomer-940 resin, stir at medium speed, and add the prescription amount in batches Resin Carbomer-941 20 parts, stirred at low speed for 2 hours until uniform, poured into a kneader, adjusted the temperature to 50°C, stirred for 2 hours, vacuumed for about 1.5 minutes, stirred evenly, and stood still to obtain a matrix.

Embodiment 2

[0021] Example 2 Take 60 parts of deionized water, 0.002 parts of disodium EDTA, 0.02 parts of Tween 80, mix well, stir at low speed, add 2 parts of Carbomer-940 resin, stir at medium speed, and add the prescription amount in batches Resin Carbomer-941 15 parts, stirred at a low speed for 2.5 hours until uniform, poured into a kneader, adjusted the temperature to 50°C, stirred for 2 hours, vacuumed, stirred evenly, and stood still to obtain a matrix.

Embodiment 3

[0022] Example 3 Take 60 parts of deionized water, 0.004 parts of disodium edetate, 0.03 parts of Tween 80, mix well, stir at low speed, add 3 parts of Carbomer-940 resin, stir at medium speed, and add the prescription amount in batches Resin Carbomer-941 20 parts, stirred at low speed for 2 hours until uniform, poured into a kneader, adjusted the temperature to 50°C, stirred for 2.5 hours, vacuumed, stirred evenly, and stood still to obtain a matrix.

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PUM

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Abstract

The present invention discloses one kind of medicine carrying aquogel matrix for preparing plaster and its preparation process. The medicine carrying aquogel matrix has the recipe comprising deionized water 60-80 weight portions, carbomer-940 resin 1-3 weight portions, carbomer-941 resin 10-20 weight portions, Tween-80 0.01-0.03 weight portions, EDTA-2-Na 0.001-0.004 weight portions, and alcohol 1-3 weight portions, and is prepared through stirring, dispersing and kneading. The present invention has facile materials, high biocompatibility, no toxicity and irritation, excellent medicine compatibility and other advantages.

Description

technical field [0001] The invention relates to a new dosage form preparation for transdermal administration, in particular to a hydrophilic gel patch matrix with high water content. Background technique [0002] Transdermal drug delivery system (TTS for short) refers to a special preparation that is pasted on the skin surface to treat systemic and local diseases after the combination of drugs and pharmaceutical excipients. It is a new preparation technology that has only developed rapidly in the world since the 1990s. It has the unique advantages that other dosage forms do not have, such as safe and convenient medication; it is most suitable for drugs that cause gastrointestinal irritation or cause decomposition; it has a long acting time and fewer medication times; it has no liver first-pass effect; it is suitable for children and the elderly, etc. The annual sales of global transdermal drug delivery system products rose from US$1.6 billion in 1993 to US$9.1 billion in 200...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K9/00A61K9/70A61K47/26
Inventor 穆晓敏黄加兰谢黄养刘强
Owner 广东新时代新材料科技有限公司
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