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Preparation method of N(2)-L-alanyl-L-glutamine

A technology of glutamine and alanyl, which is applied in the field of preparation of N-L-alanyl-L-glutamine, can solve the problems of high price, uneconomical dipeptide and high raw material price, and achieves convenient operation and less pollution , the effect of simple process

Inactive Publication Date: 2007-10-31
福建三爱药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The third route is to use L-alanine as the starting material, and generate α-Amino Acid NCA's (N-Carboxy Anhydrides) after cyclization with trichloromethyl chloroformate, and then generate amide with L-glutamine, under acidic conditions A molecule of carbon dioxide is sloughed off, thereby obtaining dipeptides in L-configuration; comparing these three routes, N-hydroxysuccinimide and DCC, which are more expensive, are used in route two; the source of raw materials in route one is convenient, However, the price of raw materials is high, and the production of dipeptide is uneconomical

Method used

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  • Preparation method of N(2)-L-alanyl-L-glutamine

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Embodiment 1

[0033] The preparation method of N(2)-L-alanyl-L-glutamine of the present invention is as follows, and its steps comprise:

[0034] 1. Preparation of potassium precursor acid

[0035] In the reactor for preparing potassium precursor acid, add 32.5g KOH, 45.0g alanine and 100ml ethanol respectively; stir at room temperature for 10 minutes, dissolve, and obtain a clear solution; then add 90.0ml ethyl acetoacetate dropwise, and reflux for 60 Minutes, the temperature in the reactor is at 68°C;

[0036] Change back distillation to distillation to recover ethanol. When the temperature in the reactor is 88°C, add 150ml of toluene to continue distillation. When the temperature in the reactor is 78°C, add 100ml of toluene, stir and distill 50ml of toluene. Distill 250ml of toluene, stir back to distill with water, distill 130ml of toluene and water in total, separate 23ml of water, stir and distill until the temperature in the reactor reaches 110°C, and crystals are precipitated, and ...

Embodiment 2

[0050] The preparation method of N(2)-L-alanyl-L-glutamine of the present invention is as follows, and its steps comprise:

[0051] 1. Preparation of potassium precursor acid

[0052] In the reactor for preparing potassium precursor acid, add 32.5g KOH, 45.0g alanine and 100ml ethanol respectively; stir at room temperature for 10 minutes, dissolve, and obtain a clear solution; then add dropwise 73.0ml acetylacetone, and reflux for 60 minutes, The temperature in the reactor is 84°C;

[0053] Change back distillation to distillation to recover ethanol. When the temperature in the reactor is 88°C, add 150ml of toluene to continue distillation. When the temperature in the reactor is 78°C, add 100ml of toluene, stir and distill 50ml of toluene. Distill 250ml of toluene, stir back to distill with water, distill 130ml of toluene and water in total, separate 23ml of water, stir and distill until the temperature in the reactor reaches 110°C, and crystals are precipitated, and cool at ...

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Abstract

The invention discloses a preparing method of N(2)-L-alanyl-L-glutamine, which comprises the following steps: producing precursor acid potassium; producing mixed acid anhydride; producing glutamine sodium salt; producing N(2)-L-alanyl-L-glutamine (ala paddy dipeptide); refining. This invention possesses the advantages of simple craft, convenient operation and little contamination.

Description

technical field [0001] The present invention relates to a preparation method of N(2)-L-alanyl-L-glutamine. Background technique [0002] Glutamine (Gln) is the most abundant amino acid in the free amino acid pool and plasma in the human body. About 80% of glutamine in the human body is distributed in the iliac muscle, and its concentration is 30 times that of plasma. The energy consumed by intestinal cells is mainly derived from glutamine released in skeletal muscle. Although glutamine is a non-essential amino acid under normal conditions, it is a conditionally essential amino acid in critically ill and malnourished patients. In critical situations such as surgery, trauma sepsis, etc., the concentration of glutamine in cells decreases, and glutamine in the body will be exhausted soon. Depletion of glutamine pools in vivo leads to atrophy of intestinal epithelial cells and may impair intestinal barrier function and facilitate bacterial translocation. Despite the physiolog...

Claims

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Application Information

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IPC IPC(8): C07K1/02C07K5/062
CPCY02P20/55
Inventor 范永军
Owner 福建三爱药业有限公司
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