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Slowly-released type nanometer silver antibacterial gel and the preparing method and the application thereof

A nano-silver antibacterial and gel technology, which is applied in antibacterial drugs, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of undisclosed preparation methods of nano-silver solutions and hydrogels, excluding sprays and their sustained-release preparations , Undisclosed nano-silver colloid preparation methods and other issues, to achieve the effect of prolonging the adhesion time, solving the narrow application range, and reducing the formation of scars

Inactive Publication Date: 2007-10-31
崔彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In China's invention patent application 200410029792.0, the preparation of nano-silver gel for treating women's reproductive tract infection is disclosed, but the preparation method of nano-silver colloid is not disclosed (nano-silver colloid is purchased); the formulation of nano-silver gel is single (propellant) , not including foams, sprays and their sustained-release preparations, etc., which are not widely used
[0009] A kind of nano-silver gel and its application are disclosed in Chinese invention patent application 200410085928.0, but the preparation method of nano-silver solution and hydrogel is not disclosed (both are outsourced); Natural plant ingredients, the composition and process are relatively complicated; the dosage form of nano-silver gel is single (propellant), excluding sustained-release dosage forms, etc., and the application of nano-silver gel is also limited
[0010] In China's invention patent application 01129507.4, a nano-silver prostate antibacterial and anti-inflammatory gel and its preparation method are disclosed. The formula includes stearic acid, sodium lauryl sulfate, etc., and the ingredients are complex; The extract is obtained by vacuum extraction, the process is complex, and the dosage form and indications are not complete

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment one: the preparation of nano-silver silica colloid:

[0054] Prescription composition:

[0055] Silver nitrate powder 32g Sodium lauryl sulfate 270g VC 20g

[0056] Nano silicon dioxide 900g Deionized water Proper amount

[0057] Made: 1000g

[0058] Process flow:

[0059] The silver nitrate of prescription quantity is joined in deionized water, dissolves at room temperature, is prepared into silver nitrate solution; Sodium lauryl sulfate is added in deionized water to be prepared into 10% (wt%) aqueous solution; Silver nitrate aqueous solution is added to In the sodium lauryl sulfate aqueous solution, stir evenly, vibrate with an ultrasonic oscillator for 2 hours, raise the temperature to 90 degrees, and keep the temperature for 2 hours; take the VC aqueous solution and add it to the above solution while stirring; react for 2 hours; take nano-silica to prepare Add 10% (wt%) nano-silica dispersion into the above solution, and stir until the nano-silver is...

Embodiment 2

[0060] Embodiment two: the preparation of constant release type nano-silver antibacterial gel:

[0061] Prescription composition:

[0062] Nano Silver Colloid 15g Carbomer 15g Sodium Lauryl Sulfate 0.001g

[0063] VC 10g glycerin 12g deionized water appropriate amount

[0064] Made: 1000g

[0065] Process flow:

[0066] Add the prescribed amount of carbomer into deionized water, dissolve and swell for 10 hours, adjust the pH to 4.0-4.5 with sodium hydroxide, add the above-mentioned raw materials into the carbomer solution in turn, and stir thoroughly for 1 hour to obtain nano-silver antibacterial gel agent. The nano-silver antibacterial gel is subpackaged according to the preparation specifications.

Embodiment 3

[0067] Embodiment three: the preparation of temperature-sensitive slow-release nano-silver antibacterial gel:

[0068] Prescription composition:

[0069] Nano Silver Colloid 10g Polycarbophil 5g Carbopol 10g

[0070] Poloxamer F127 150g Poloxamer F68 50g Glycerin 50g

[0071] Sodium lauryl sulfate 0.001g Deionized water Proper amount

[0072] Made: 1000g

[0073] Process flow:

[0074] Add the prescribed amount of polycarbophil and carbomer into deionized water, dissolve and expand for 10 hours, adjust the pH to 4.5-5.5 with sodium hydroxide, add the above-mentioned raw materials into the above-mentioned solution in turn, and stir thoroughly for 1 hour to obtain a temperature-sensitive Sustained-release nano-silver antibacterial gel. Subpackage according to the requirements of the preparation specifications.

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Abstract

The invention discloses an externally used nanometer silver antibiotic jel line products, which is characterized by the following: constituting with acceptable shaped agent, diluent, slow releasing agent, disperser on nanometer silver and medicinal; setting the grain size of the nanometer silver at 1-25nm; comprising push injecting agent, foam spray, aquagel cleaning solvent, spray and so on of nanometer silver antibiotic jel line products. This invention also relates to the preparing method of nanometer silver colloid and nanometer silver antibiotic jel line products. This product can be used to cure vaginitis, cervicitis, mixing infection type gynaecologic inflammation, prostatitis, prostate proliferation, prostatauxe, male urethritis, balanitis, posthitis and so on.

Description

technical field [0001] The invention relates to a medicine for treating genitourinary infections of men and women, in particular to an external nano-silver antibacterial gel for treating the above-mentioned diseases and the industrial production method and application of the medicine. It belongs to the technical field of medicine and its preparation method. Background technique [0002] Common female reproductive tract diseases are: vaginitis, cervicitis, pelvic inflammatory disease, annex inflammation, etc. Usually due to bacterial or viral infection. According to the latest survey report of the World Health Organization, for adult women, the most common disease is not a cold, but a reproductive tract infection; the most common discomfort symptoms are not fever, headache, etc., but itching, odor, pain, etc. in the private parts . Adult women have a 61% chance of developing a genital tract infection; approximately 60% of women devote 3-6 days a month to treating a genital...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/00A61K8/19A61K47/04A61K47/32A61K47/34A61P31/04A61P13/00A61P13/02A61P13/08A61P15/00A61P15/02A61K47/10
Inventor 董振敏
Owner 崔彬
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