Medicinal composition for treating osteoporosis and its preparations and application

A traditional Chinese medicine preparation and osteoporosis technology, which is applied in the research and development field of new traditional Chinese medicines, can solve the problem of high production cost, and achieve the effects of low cost, simple process and high extraction and transfer rate.

Active Publication Date: 2007-10-24
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, only psoralen is obtained by this extraction method, and secondly, although this method improves the extraction rate of active ingredients,...

Method used

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  • Medicinal composition for treating osteoporosis and its preparations and application
  • Medicinal composition for treating osteoporosis and its preparations and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] [Example 1] The preparation method of psoralen total coumarin

[0137] Get 2000g of psoralen medicinal material (the average content of psoralen total coumarin in the medicinal material is 2.07%), be ground into a medicated powder of 10 mesh sieves, soak in 70% ethanol for 24 hours and extract by percolation, and reduce the percolation liquid at 60° C. Concentrate under pressure to a concentrated solution with a relative density of 1.10-1.15 (50°C), add 1 times the weight and volume of the medicinal materials, that is, 2000ml of absolute ethanol to dissolve, centrifuge to remove impurities, and then add D-101 macroporous adsorption to the supernatant Stir the resin evenly, evaporate the solvent in a water bath at 70°C, put it on a D-101 macroporous adsorption resin column by dry method, remove impurities with distilled water and 10% ethanol respectively, and finally elute the resin column with 50% ethanol, collect the eluate, Concentrate under reduced pressure (60°C, -0...

Embodiment 2

[0138] [embodiment 2] the preparation method of psoralen total coumarin

[0139] Get 2000g of psoralen medicinal material (the average content of psoralen total coumarin in the medicinal material is 2.07%), be ground into a medicated powder of 40 mesh sieves, soak in 95% ethanol for 24 hours and then extract by percolation, and reduce the percolation liquid at 60°C. Concentrate under pressure to a concentrated solution with a relative density of 1.10 to 1.15 (50°C), add 3 times the weight and volume of the medicinal materials, that is, 6000ml ethyl acetate to dissolve, centrifuge to remove impurities, and get a supernatant, add ZTC macroporous adsorption resin to the supernatant, Stir evenly, evaporate the solvent in a water bath at 70°C, put it on a ZTC type macroporous adsorption resin column by dry method, remove impurities with distilled water and 35% ethanol, and finally elute the resin column with 60% ethanol, collect the eluate, and concentrate under reduced pressure ( ...

Embodiment 3

[0140] [embodiment 3] the preparation method of psoralen total coumarin

[0141] Take 2000 g of psoralen medicinal material (the average content of total coumarin in psoralen is 2.07%), pulverize into a 40-mesh sieve powder, reflux extraction with 30% ethanol, and concentrate the reflux extract at 60° C. under reduced pressure to relative density It is a concentrated solution of 1.10~1.15 (50°C), add 2 times the weight volume of medicinal materials, that is, 4000ml acetone to dissolve, centrifuge and remove impurities to obtain a supernatant, add AB-8 macroporous adsorption resin to the supernatant, stir evenly, 70°C Evaporate the solvent in a water bath, put the AB-8 type macroporous adsorption resin column on the dry method, remove impurities with distilled water and 30% ethanol respectively, and finally elute the resin column with 70% ethanol, collect the eluate, concentrate under reduced pressure (60 ° C, -0.09MPa), vacuum drying (60°C, -0.09MPa), pulverized to obtain 52.7...

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Abstract

The invention relates to a Chinese medicinal composition for treating osteoporosis, wherein the active constituent is the significant portion of total-coumarines of fructus psoraleae extracted from traditional Chinese medicament of psoralea fruit. The invention also provides the process for preparing the medicinal composition and related dose forms.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating osteoporosis, its preparation and application. Background technique [0002] Osteoporosis (OP, Osteoporosis) is a metabolic bone disease characterized by decreased bone mass per unit volume, degeneration of bone microarchitecture, thinning of bone mass, decreased number of bone trabeculae, widened bone marrow cavity, and decreased bone strength. It is a systemic disease that leads to increased bone fragility and susceptibility to fractures. Its clinical symptoms are mainly bone pain, turtle back, fractures, and fatigue. It is estimated that there are at least 83.9 million people suffering from this disease in my country at present, and it will reach 114 million people in 2010, and 151.3 million people in 2025. The report of the national "95" research project "Osteoporo...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61K31/37A61K9/06A61K9/08A61K9/12A61K9/16A61K9/19A61K9/20A61K9/48A61K9/70A61P19/10A61K131/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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