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Application of brucea fruit oil nanometer emulsion in preparing gastrointestinal mucosa protective agent

A technology of javanica javanica oil and gastrointestinal mucosa, which is applied in the field of medicine, can solve problems such as unstable process, unstable quality, and short validity period, and achieve the effects of simple preparation process, protection of gastrointestinal mucosa, and low cost

Inactive Publication Date: 2007-10-17
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Brucea javanica oil emulsion has many disadvantages, such as large and uneven particles (500-1000nm), unstable process, unstable quality, corruption, delamination, coagulation in flocculent during storage, short validity period, and exposure to light and humidity. , thermal instability and light, high temperature, high humidity will change from appearance to content, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: 10% Brucea javanica oil nanoemulsion soft capsule

[0030] Prescription: Refined javanica javanica oil is prepared by the method disclosed in Chinese patent application CN200310108330.4.

[0031] Refined javanica oil 10ml

[0032] Phospholipids 9g

[0033] Refined hydrogenated castor oil (BASF, Germany) 50ml

[0034] Polyethylene glycol stearate (BASF, Germany) 9g

[0035] Ethanol 1ml

[0036] Add double distilled water to a total volume of 100ml

[0037] Preparation:

[0038] (1) Weigh the prescribed amount of phospholipids, add appropriate amount of double-distilled water, expand at 80°C for 2 hours, and let cool to room temperature;

[0039] (2) Take by weighing the prescription amount of refined javanica javanica oil, refined hydrogenated castor oil, polyethylene glycol stearate and mix uniformly; add (1) liquid and ethanol respectively under stirring; add double distilled water to 100ml after stirring thoroughly, A clear yellow solution was obt...

Embodiment 2

[0041] Example 2: Protective effect on aspirin-induced gastric ulcer in mice

[0042] 1. Experimental method:

[0043] 50 Kunming mice, male and female, half and half, body weight 18~22g, were divided into 5 groups at random, i.e. blank control group (giving 0.5% CMC), javanica javanica oil nanoemulsion (prepared by embodiment 1) low and medium , high-dose group (respectively 0.4, 0.8, 1.6g / kg, which are about 1, 2, and 4 times the daily equivalent dose (converted according to body surface area) of human clinical intended use respectively), teprenone (Shi Weishu, Japan Health Material Co., Ltd.) group (0.04g / kg, approximately equivalent to twice the clinical daily equivalent dose (converted according to body surface area)), continuous gavage for 3 days, fasting for 24 hours before the last administration. 1 hour after the last dose, aspirin (200 mg·kg -1 ) gavage, and executed after 4 hours, opened the abdominal cavity, ligated the pylorus and cardia, injected 1ml of 1% form...

Embodiment 3

[0052] Embodiment 3: Effect of javanica javanica oil nanoemulsion on gastric ulcer in rats with pylorus ligation

[0053] 1. Experimental method

[0054]50 Wistar rats, female and male half and half, body weight 180~220g, are divided into 5 groups at random, are respectively blank control group (gavage 0.5%CMC-Na); ) low, medium and high dose groups (0.3, 0.6, 1.2 g / kg of the test drug were administered intragastrically, respectively, which were about 1, 2, and 4 times of the daily equivalent dose for human clinical use (converted according to the body surface area equivalent dose method) )), the positive drug group (administration of Shiweishu 0.03g / kg, which is approximately equivalent to twice the equivalent clinical daily dose for humans (converted according to the body surface area equivalent dose method)). Continuous gavage for 3 days, once a day, fasting for 48 hours before the last gavage. One hour after the last gavage, the animals were anesthetized with ether, the ...

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PUM

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Abstract

The invention discloses an application of the for brucea javanica oil nanoemulsions for preparing gastrointestinal mcous membrane protecting agent belonging to the medicine field. Brucea javanica oil nanoemulsions gastrointestinal mcous membrane protecting agent is natural brucea javanica oil, which is not used any poisonous chemical substance, and has no poisonous, side effects and allergic reaction , however has a safe application, a simple producing craft and a low cost. It is a pioneer gastrointestinal mcous membrane protecting agent extracted from the natural plants and fills the blank in this area.

Description

technical field [0001] The invention relates to the application of javanica javanica oil nanoemulsion in the preparation of a protective agent for gastrointestinal mucosa, belonging to the field of medicine. Background technique [0002] Chronic gastritis is a common and frequently-occurring disease. According to domestic gastroscopic examination results, more than 90% of the subjects are chronic gastritis. Due to the development of chronic gastritis, intestinal metaplasia, dysplasia and some final cancers may occur, and cancer deaths in China Gastrointestinal cancer still ranks first in the ranking of cancer rates. Therefore, it is very important to block the development of chronic gastritis and prevent the occurrence of gastric cancer. [0003] Helicobacter pylori (H.Pylori, Hp) is the main cause of gastritis and one of the causes of biological carcinogenesis. Using Hp eradication therapy commonly used at home and abroad, the clinical symptom relief rate after eradicatio...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/107A61K9/48A61P1/04
Inventor 于中麟姚崇舜张澍田项琪
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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