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Preparation method of salvia miltiorrhiza tanshinoate A

A technology of salvianolic acid and salvianolic acid, applied in the field of preparation of salvianolic acid A, can solve the problem of industrial production of salvianolic acid A, low yield of salvianolic acid A and high production cost. problems, to achieve the effect of cost reduction, improvement of curative effect and stable quality

Active Publication Date: 2007-09-26
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because the content of salvianolic acid A in medicinal materials is low or even absent, the yield of salvianolic acid A is low, the production cost is high, and there are certain limitations in large-scale industrial production. In fact, it cannot fundamentally solve the problem of salvianolic acid A. industrial production problems

Method used

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  • Preparation method of salvia miltiorrhiza tanshinoate A

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Effect test

Embodiment 1

[0031] Embodiment one: the preparation method of salvianolic acid A, its processing step is:

[0032] 1. Water extraction (warm immersion method): Add 8 times the amount of red sage powder to warm immersion at 80°C for 3 times, each time for 1.0 hour, and filter.

[0033] 2. Purification of salvianolic acid A by column chromatography: centrifuge the combined filtrates (4000 rpm) for 10 minutes, take the supernatant and pass it through a 1400 macroporous adsorption resin column, wash with water until the sugar detection reaction is negative, and then use 20% ethanol Eluted to FeCl 3 Response was negative.

[0034] 3. Then elute with 40% ethanol to FeCl 3 The reaction was negative, and the eluate was collected and concentrated under reduced pressure at 60°C until there was no alcohol smell.

[0035] 4. Adjust the pH value and extract with organic solvent: add hydrochloric acid to adjust the pH value to 3-5, extract 4 times with ethyl acetate of 1.5 times the volume of the dru...

Embodiment 2

[0037] Embodiment two: basically the same as embodiment one, the difference is that the extraction process is reflux extraction of 60% ethanol aqueous solution. The specific method is as follows:

[0038] Salvia miltiorrhiza coarse powder, add 10 times the amount of 60% ethanol to reflux and extract 3 times, each time for 1.5 hours, and filter.

Embodiment 3

[0039] Embodiment 3: It is basically the same as Embodiment 1, except that the extract is centrifuged and filtered to initially remove solid impurities.

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Abstract

The invention discloses a making method of salviol acid A, which comprises the following steps: extracting salvia miltiorrhizae through water or alcohol; removing solid impurity; purifying salviol acid A through column chromatogram; condensing eluent; adjusting pH value of organic solvent; extracting; condensing; drying; obtaining the product with high-extracting rate; fitting for large-scale of manufacturing.

Description

technical field [0001] The present invention relates to a kind of preparation method of salvianolic acid A, the structure of salvianolic acid A is as follows: [0002] technical background [0003] Danshen is one of the most commonly used medicinal materials for the treatment of cardiovascular and cerebrovascular diseases such as angina pectoris, hypertension, coronary heart disease and stroke. However, the crude extract extracted from Salvia miltiorrhiza or directly used in slices of Danshen is generally used. In the past two decades, salvianolic acid compounds, the main active components of Danshen, have been discovered one after another. The results of in vitro experiments show that salvianolic acid compounds can not only treat cardiovascular and cerebrovascular diseases, but also treat various diseases, such as liver disease, kidney disease, peptic ulcer, tumor and so on. Salvianolic acid B has the highest content among the total phenolic acids of salvia miltiorrhiz...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/732A61K36/53A61K125/00
Inventor 黎豫杭柴建国张善飞潘迎锋张建兵
Owner CHIATAI QINGCHUNBAO PHARMA
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