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Dengyin naotong drop pills

A technology of dripping pills and dripping pills, which is applied in the fields of pill delivery, plant raw materials, cardiovascular system diseases, etc. It can solve the problems of easy water absorption and deliquescence, large disintegration particle size, and delayed treatment timing.

Inactive Publication Date: 2007-09-26
王庆忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disintegration time of Dengyinnaotong Capsules is long, the disintegration particle size is large, and the dissolution rate of active ingredients is slow, resulting in slow curative effect and delaying the timing of treatment
[0006] 2. As a drug for treating stroke, it needs to be small in size and easy to carry, but Dengyinnaotong capsules are large in size and inconvenient to carry
[0007] 3. One of the ingredients of Dengyinnaotong capsules is ginkgo biloba, its extract is easy to absorb water and deliquescence, and the medicine is agglomerated, so it is not easy to store for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Weigh 500g of Erigeron breviscapus, 500g of Manshanxiang, 500g of Ginkgo biloba leaves, and 200g of Panax notoginseng. Four-flavored raw medicinal materials, add 10 times the amount of water to soak for 4 hours, decoct 3 times, 2 hours each time, combine the decoction, filter, add ethanol to the filtrate to make the alcohol content reach 70%, mix well, let stand for 24 hours, Filtrate, recover ethanol from the filtrate until it has no alcohol smell, spray dry it into powder, and obtain 105g of active ingredient; the liquid inlet speed of spray drying is 9V, the inlet air temperature is 210°C, and the outlet air temperature is 70°C;

[0052] Mix 105g of active ingredients with 155g of PEG6000 and 40g of PEG1500 matrix, stir well, keep warm at 80±2°C, use simethicone as coolant for dropping pills, the cooling temperature of the coolant is 10°C, the drop distance is 8cm, and the drop speed is 30 drops / minute, make 7500 drop pills, each weighing 40mg, packed in p...

Embodiment 2

[0054] Example 2: Weigh 500g of Erigeron breviscapus, 500g of Manshanxiang, 500g of Ginkgo biloba leaves, and 200g of Panax notoginseng. Four-flavored raw medicinal materials, add 10 times the amount of water to soak for 4 hours, decoct 3 times, 2 hours each time, combine the decoction, filter, add ethanol to the filtrate to make the alcohol content reach 70%, mix well, let stand for 24 hours, Filtrate, recover ethanol from the filtrate until it has no alcohol smell, spray dry it into powder, and obtain 100g of active ingredient; the liquid inlet speed of spray drying is 10V, the inlet air temperature is 220°C, and the outlet air temperature is 75°C;

[0055] Mix 100g of active ingredients with 100g of PEG6000 and 50g of PEG1500 matrix, stir well, keep warm at 80±2°C, use simethicone as coolant for dropping pills, the cooling temperature of the coolant is 10°C, the drop distance is 8cm, and the drop speed is 30 drops / minute, make 6250 drop pills, each weighing 40mg, packed i...

Embodiment 3

[0056] Usage and dosage: take orally, 15 pills each time, 3 times a day, 14 days as a course of treatment; or follow the doctor's advice. Example 3: Weigh 500g of Erigeron breviscapus, 500g of Manshanxiang, 500g of Ginkgo biloba leaves, and 200g of Panax notoginseng. Four-flavored raw medicinal materials, add 10 times the amount of water to soak for 4 hours, decoct 3 times, 2 hours each time, combine the decoction, filter, add ethanol to the filtrate to make the alcohol content reach 70%, mix well, let stand for 24 hours, Filtrate, recover ethanol from the filtrate until it has no alcohol smell, spray dry it into powder, and obtain 105g of active ingredient; the liquid inlet speed of spray drying is 12V, the inlet air temperature is 230°C, and the outlet air temperature is 80°C;

[0057] Mix 100g of active ingredients with 250g of PEG6000 and 50g of PEG1500 matrix, stir well, keep warm at 80±2°C, use simethicone as coolant for dropping pills, the cooling temperature of the coo...

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PUM

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Abstract

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases, which is a dripping pill prepared from effective dose of base material and the following raw material effective composition (by weight portion): herba erigerontis 500g, orange-jasmine 500g, ginkgo leaves 500g, and notoginseng 200g. The medicament has the advantages of rapid dissolving rate, complete absorption and high biological availability.

Description

(1) Technical field [0001] The invention relates to a medicine for treating cerebrovascular diseases, in particular to Dengyinnaotong dripping pills. (2) Background technology [0002] Stroke, also known as cerebral apoplexy, is called acute cerebrovascular disease in modern medicine. It is a common disease of middle-aged and elderly people. It is an urgent, difficult and severe disease that seriously threatens human health. According to relevant reports, it has accounted for 22% to 24% of the total death toll; it has become one of the three major deadly diseases in contemporary times. [0003] Dengyin Naotong Capsules are recorded in the Meridians, Limbs, Limbs and Brain System Subvolume of National Standards of Chinese Proprietary Medicines in "Compilation of National Standards of Chinese Proprietary Drugs of the State Drug Administration" [Standard Number: WS-10843(ZD-0843)-2002]. Yi medicine: Ximi Qienu, Woge Nuwo leather clothes, Chama Oumi. Traditional Chinese Medici...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K36/45A61K36/54A61K36/56A61K36/57A61K36/74A61K36/75A61K36/758A61K9/20A61P9/10
Inventor 李保国耿鲁骏王浩骅孙建海马全龙王莉洁
Owner 王庆忠
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