Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine composition for expanding blood volume and the preparing method thereof

The technology of a composition and medicine is applied in the field of medicine composition for expanding blood volume and its preparation, and can solve the problems of high chloride metabolic acidosis and the like

Active Publication Date: 2010-05-12
BEIJING FRESENIUS KABI PHARM CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a pharmaceutical composition for expanding blood volume, to overcome the hyperchloric metabolic acidosis that is prone to occur during the use of the existing colloid plus normal saline combination

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine composition for expanding blood volume and the preparing method thereof
  • Medicine composition for expanding blood volume and the preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The pharmaceutical composition for expanding blood volume of the present invention is prepared according to the following prescription. The average molecular weight of the hydroxyethyl starch used therein is 130,000±20,000; the degree of substitution MS is 0.38-0.45.

[0030] Table 1. Prescription (per 1L) for solution preparation in the embodiment 1

[0031] Hydroxyethyl starch

60.00g

Sodium acetate trihydrate

4.63g

Sodium chloride

6.02g

potassium chloride

0.30g

Magnesium chloride hexahydrate

0.30g

[0032] The production method is prepared according to the following method

[0033] Solution preparation

[0034] Inject water for injection into the liquid preparation tank, add hydroxyethyl starch and stir to dissolve it. After fully dissolved, sodium acetate, sodium chloride, potassium chloride and magnesium chloride were added and stirred to dissolve. Finally, dilute to the final concentration wit...

Embodiment 2

[0045] The pharmaceutical composition for expanding blood volume of the present invention is prepared according to the following prescription. The average molecular weight of the hydroxyethyl starch used therein is 240,000±5,0000; the degree of substitution MS is 0.43-0.55.

[0046] Table 3. Prescription (per 1L) for solution preparation in the embodiment 2

[0047] Hydroxyethyl starch

100.00g

Sodium acetate trihydrate

5.17g

Sodium chloride

5.73g

potassium chloride

0.34g

Magnesium chloride hexahydrate

0.24g

[0048] The production method is prepared according to the following method

[0049] Solution preparation

[0050] Inject water for injection into the liquid preparation tank, add hydroxyethyl starch and stir to dissolve it. After fully dissolved, sodium acetate, sodium chloride, potassium chloride and magnesium chloride were added and stirred to dissolve. Finally, dilute to the final concentration wi...

Embodiment 3

[0061] The pharmaceutical composition for expanding blood volume of the present invention is prepared according to the following prescription. The average molecular weight of the hydroxyethyl starch used therein is 130,000±20,000; the degree of substitution MS is 0.38-0.45.

[0062] Prescription (per 1L) for solution preparation in table 5. embodiment 3

[0063] Hydroxyethyl starch

60.00g

Sodium acetate trihydrate

3.40g

Sodium chloride

7.02g

potassium chloride

0.19g

[0064] Hydroxyethyl starch

60.00g

Magnesium chloride hexahydrate

0.22g

[0065] The production method is prepared according to the following method

[0066] Solution preparation

[0067] Inject water for injection into the liquid preparation tank, add hydroxyethyl starch and stir to dissolve it. After fully dissolved, sodium acetate, sodium chloride, potassium chloride and magnesium chloride were added and stirred to dis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of substitutionaaaaaaaaaa
Login to View More

Abstract

The present invention discloses one kind of medicine composition for expanding blood volume and its preparation process. The medicine composition includes hydroxyethyl starch, sodium ion, potassium ion, magnesium ion, chlorine ion, and acetate radical or lactate radical ion. The medicine composition is used for preventing and treating hypovolemia and may be used in great dosage infusion without risk of hyperchloremic metabolic acidosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for expanding blood volume and a preparation method thereof. Background technique [0002] Volume therapy has always been one of the important means in emergency resuscitation, perioperative surgery and critical care medicine. Therefore, choosing the appropriate type of fluid for safe and effective volume therapy is crucial to maintaining the organ function of patients, and to some extent affects the prognosis and outcome of the disease. Crystalloids, colloids, and whole blood are commonly used clinical volume supplements. In recent years, artificial colloids, especially hydroxyethyl starch, have been widely used clinically. Injection containing hydroxyethyl starch is used to maintain circulating blood volume (emovolemia) or to treat hypovolemia, including conditions such as surgery, trauma, burns, and infection. In addition, hydroxyethyl starch can be used as a blood thinner for extracorporeal c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/718A61K47/12A61K47/02A61P7/08
Inventor 不公告发明人
Owner BEIJING FRESENIUS KABI PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com