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Technology for preparing medicine and relative oral preparations

A technology for preparation process and related products, which is applied in the field of preparation process for oral preparations, can solve problems such as difficult acceptance by patients, achieve the effects of accelerating dissolution and absorption, and improving bioavailability and stability

Inactive Publication Date: 2007-08-29
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral doses of many traditional Chinese medicines and some chemically synthesized drugs clinically used are in the gram level. Therefore, if considering the factors of the limited drug load of the drop pills, even if a large drop pill of 150 mg is used, more than 20 pills should be taken at a time, which is not easy for the patient. accepted by patients

Method used

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  • Technology for preparing medicine and relative oral preparations
  • Technology for preparing medicine and relative oral preparations
  • Technology for preparing medicine and relative oral preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1-influence of the present invention on the dissolution property of water-insoluble drug

[0039] Drug: Irbesartan, a water-insoluble drug.

[0040] Dosage Form: Tablet

[0041] method:

[0042] 1. The preparation process of the control group: take 15 grams of irbesartan, 5 grams of pregelatinized starch, 6 grams of micropowder silica gel, 26 grams of polyethylene glycol 6000, mix well, wet granulate with 10% PVPk30, and dry at 37 ° C , through a 20-mesh sieve, add 9 grams of microcrystalline cellulose, 8.5 grams of sodium carboxymethyl starch, and 0.5 grams of magnesium stearate, fully stir and mix evenly, and press 0.35g irbesartan tablets on a tablet machine, each tablet Contains irbesartan 75mg.

[0043] 2. The preparation process of the experimental group of the present invention: respectively take 15 grams of irbesartan, 5 grams of pregelatinized starch, 6 grams of micropowdered silica gel, and 26 grams of polyethylene glycol 6000, mix them evenly, a...

Embodiment 2

[0046] Embodiment 2-the influence of the present invention on the dissolution of poorly soluble drugs

[0047] Drug: propafenone hydrochloride is a poorly water-soluble drug.

[0048] Dosage Form: Tablet

[0049] method:

[0050] 1. The preparation process of the control group: take 15 grams of propafenone hydrochloride, 3 grams of polyethylene glycol 4000, and 12 grams of polyethylene glycol 6000 respectively, mix well, dry granulate, pass through a 20-mesh sieve, and press heavy 0.3g propafenone hydrochloride tablets, each containing 150 mg propafenone hydrochloride.

[0051] 2. The preparation process of the experimental group of the present invention: take 15 grams of propafenone hydrochloride, 3 grams of polyethylene glycol 4000, and 12 grams of polyethylene glycol 6000, mix well, and heat the prepared raw and auxiliary material mixture by electric heating To a molten state, cooled and solidified, granulated, passed through a 20-mesh sieve, and pressed on a tablet mach...

Embodiment 3

[0054] Embodiment 3-the influence of the present invention on the dissolution of slightly soluble drugs in water

[0055] Drug: Amoxicillin, a slightly soluble drug in water.

[0056] Dosage Form: Tablet

[0057] method:

[0058] 1. The preparation process of the control group: respectively take 15 grams of amoxicillin, 3 grams of polyethylene glycol 4000, and 12 grams of polyethylene glycol 6000, mix well, dry granulate, pass through a 20-mesh sieve, and press on a tablet machine with a weight of 0.3 g Amoxicillin tablets, each containing 150 mg of amoxicillin.

[0059] 2, the preparation process of the experimental group of the present invention: take respectively 15 grams of amoxicillin, 3 grams of polyethylene glycol 4000, and 12 grams of polyethylene glycol 6000, and mix them evenly; Molten state, cooled and solidified, granulated, passed through a 20-mesh sieve, and pressed on a tablet machine to weigh 0.3g amoxicillin tablets, each containing 150 mg of amoxicillin. ...

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Abstract

The present invention discloses a preparation process of oral preparation for preparing medicine and its related product. It is characterized by that the active component and matrix are heated to form a molten mixed solution state, then cooled and solidified, and further made into the required dosage form. Said invention is applicable to preparation of medicine and health-care food.

Description

[0001] [Technical field] A preparation process for preparing oral preparations of medicines and related products. [Background technique] [0002] There are many kinds of oral preparations currently used clinically for the preparation of medicines and health foods, commonly used are tablets, capsules, soft capsules, granules, powders, pills, drop pills, oral liquids, syrups, decoctions, candies, etc. . Tablets include ordinary tablets, sustained-release tablets, controlled-release tablets, buccal tablets (suction tablets), chewable tablets, effervescent tablets, etc.; capsules include ordinary capsules, sustained-release capsules, controlled-release capsules, and enteric-coated capsules etc.; pills include honey pills, water honey pills, water pills, concentrated pills, dripping pills, etc. Dropping pills refer to solid or liquid medicines that are heated, melted and mixed with a suitable matrix, and then the medicines are dissolved, emulsified or suspended in the matrix, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K9/14A61K47/34A61K47/10
Inventor 刘凤鸣梁洁
Owner 刘凤鸣
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