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Hollow silicon gel nano powder material and its preparation method

A technology of silica gel nano and bulk materials, applied in the direction of silicon oxide, silicon dioxide, etc., can solve the problems of the absence of a large-scale continuous hollow structure, encapsulation and release restrictions, unfriendly reagents, etc., and achieve nano-sphere particle size. and the shell wall thickness is easy to control, the structure is stable, and the effect of excellent safety

Inactive Publication Date: 2007-08-01
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this method, calcination is also used to remove polymer organic molecules, but the shell pores can only be used for the internal and external transport of small molecules of the guest, and the encapsulation and release of drugs and biomacromolecules with large volume and complex molecular structure are limited.
In addition, Chinese patents CN1539733A, CN1730389A, and CN1816493 respectively disclose methods for preparing silica nanospheres with mesoporous structures, but the silica nanospheres prepared by these methods only have mesoporous channels inside, and there is no large-scale continuity. Hollow structure, and the preparation process requires high-temperature calcination to remove the organic surfactant, the process is complex
[0004] According to relevant patent technologies and literature reports, it is found that the existing hollow silica or silica gel microspheres and their preparation technologies cannot realize: (1) in-situ modification of the inner surface of the sphere with organic molecules with excellent biocompatibility; ( 2) The large and small molecules of the guest substance are easily transported inside and outside; (3) Avoid the use of environmentally unfriendly reagents

Method used

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  • Hollow silicon gel nano powder material and its preparation method
  • Hollow silicon gel nano powder material and its preparation method
  • Hollow silicon gel nano powder material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) Add 1.0mL of 30% sodium polyacrylate aqueous solution (the average molecular weight of sodium polyacrylate is 2.5KDa) to 26.2mL of deionized water under magnetic stirring conditions, 2.2mL of ammonia water and 0.6mL of molar concentration are 0.5mol / L calcium nitrate aqueous solution, the solution was stirred at room temperature for more than 2 minutes to obtain a clear mixed aqueous solution of sodium polyacrylate and calcium nitrate for subsequent use;

[0034] 2) Add 1.6mL tetraethyl orthosilicate to 70mL absolute ethanol under magnetic stirring condition, stir at room temperature for 2 minutes, set aside;

[0035] 3) Pour the mixed aqueous solution of clarified sodium polyacrylate and calcium nitrate prepared in step 1) into a clean three-necked flask, and place it in a water bath of an ultrasonic cleaner (40KHz, 80W), turn on the ultrasonicator, and add Stir mechanically (240rpm), then add the ethyl tetrasilicate ethanol solution prepared in step 2) into the abo...

Embodiment 2

[0037] 1) Add 1.5mL of 2% sodium polyacrylate aqueous solution (the average molecular weight of sodium polyacrylate is 1000KDa) to 15.5mL of deionized water successively under magnetic stirring conditions, 2.5mL of ammonia water and 0.5mL with a molar concentration of 0.5 mol / L strontium nitrate aqueous solution, the solution was stirred at room temperature for more than 2 minutes to obtain a clear mixed aqueous solution of sodium polyacrylate and strontium nitrate for subsequent use;

[0038] 2) Add 2.0 mL of tetraethyl orthosilicate to 78 mL of absolute ethanol under magnetic stirring conditions, stir at room temperature for 2 minutes, and set aside.

[0039] 3) Pour the mixed aqueous solution of clarified sodium polyacrylate and strontium nitrate prepared in step 1) into a clean three-necked flask, and place it in the water bath of the ultrasonic cleaner equipment, turn on the ultrasonic cleaner, and add mechanical stirring (300rpm) into the flask , and then adding the etha...

Embodiment 3

[0041] Same as Example 1, the difference is that 1.2mL of sodium polyaspartate with an average molecular weight of 5KDa is used to replace 1.0mL of sodium polyacrylate with an average molecular weight of 2.5KDa, the product is hollow silica gel nanospheres (Figure 7c), and the particles The molecular content of sodium polyaspartate on the outer surface is extremely low (see Figure 6b).

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Abstract

The invention discloses a nanometer ball powder material of hollow silicon gel, which comprises the following steps: blending long-chained organic molecule, ammonia and inorganic salt with alkaline metal ion into deionized water; stirring to form clear solution; adding alcohol solution with silicon source; stirring; proceeding ultrasonic cavitation disposal; filtering; washing; drying; obtaining the product with through-out pore path on the case and inner wall surface of case decorated by organic molecule.

Description

technical field [0001] The invention relates to a hollow silica gel nanosphere powder material and a preparation method thereof, belonging to the field of inorganic porous materials. Background technique [0002] In recent years, the practical application value of silicon nanomaterials and their specific performance in applications have attracted more and more attention. Among them, mesoporous and hollow silicon nanomaterials are widely used in Nanoelectronic components, catalysis and wastewater treatment all have good application potential; not only that, silicon dioxide and silica gel also have excellent biocompatibility, and the slow release of silicon in the physiological environment is the key to human bone development. Therefore, hollow silica and silica gel microspheres also have wide application potential in the fields of biomedicine and biotechnology such as the immobilization, encapsulation or controlled release of enzymes, drugs, proteins, DNA, etc. [0003] In 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/14
Inventor 苟中入翁文剑
Owner ZHEJIANG UNIV
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