Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biodegradable imaging microspheres vascular embolization material

A biodegradable material and a biodegradable technology are applied in the field of biodegradable imaging microsphere vascular embolization materials, which can solve the problems of affecting long-term curative effect, prone to false embolization, difficult operation, etc., achieving good positioning, avoiding false embolization, good visibility

Inactive Publication Date: 2007-08-01
李艳芳 +1
View PDF0 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical use, spring steel rings, surgical thread, and gelatin sponge have good clinical effects in embolizing large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation
Liquid embolic agents such as cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to misembolization in clinical operations and difficult to operate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable imaging microspheres vascular embolization material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: The developed polylactic acid (PLA) microspheres of the present invention

[0016] An angiographic contrast agent, such as the ionic contrast agent Urografin, is purchased on the market, after being processed by a vacuum freeze-drying method, the remaining material after freeze-drying is retained as a developing material (2).

[0017] The use of polylactic acid as the biodegradable material (1) and the general process of manufacturing drug-containing microspheres according to the polylactic acid as the packaging material of various drugs can conveniently manufacture the developing material (2) microspheres.

[0018] Polylactic acid is used as a packaging material for various drugs to manufacture drug-containing microspheres, and there have been many general processes. For example, Yang Fan et al. published "Study on the Preparation Technology of Ciprofloxacin Polylactic Acid Microspheres" in "Journal of China Pharmaceutical University, 2004, 35(3):207-210". Prepa...

Embodiment 2

[0022] Example 2: Developed polylactic acid glycolic acid copolymer (PLGA) microspheres of the present invention

[0023] The production method of the product of this embodiment is basically the same as that of embodiment 1, except that the biodegradable material (1) is selected as polylactic acid glycolic acid copolymer, and the developing material (2) can be selected from one of the following substances: The remaining substance after vacuum freeze-drying of the contrast agent diatrizoate meglumine; the non-ionic contrast agent Iohexol (Iohexol) or iopromide (Iopromide) or Iopamidol is processed by vacuum freeze-drying The remaining substance after the treatment; the remaining substance after the non-ionic dimer Iotrolan and other angiographic contrast agents are processed by the vacuum freeze-drying method.

[0024] Both the developed PLA microspheres and the developed PLGA microspheres of the present invention are prepared by the emulsification dispersion method and the phase s...

Embodiment 3

[0025] Example 3: The developed polycaprolactone-polyglycolide-polyglycolide copolymer microspheres of the present invention

[0026] The production method of the product of this embodiment is basically the same as that of embodiment 1, except that the biodegradable material (1) is selected as polycaprolactone-polyglycolide-polyglycolide copolymer, and the developing material (2) can be One of the following substances: the remaining substance after the ionic contrast agent diatrizoate meglumine is processed by vacuum freeze-drying; the non-ionic contrast agent Iohexol or Iopromide or Iopromide Iopamidol is the remaining material after vacuum freeze-drying; non-ionic dimer Iotrolan and other angiographic contrast agents are vacuum-freeze-dried. Use general emulsification dispersion method and phase separation coagulation method to prepare microspheres or CO 2 New supercritical fluid technology to prepare microspheres.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a biological decomposable developing micro sphere typed vascular plug material, which comprises the following parts: biological decomposable material, developing material without permeating X ray and antineoplastic agent. The invention is convenient to adjust time to do biological decomposition, which can do MRI examination after plugging.

Description

Technical field [0001] The invention relates to a vascular embolization material, in particular to a biodegradable and developing microsphere type vascular embolization material. Background technique [0002] In the prior art, there are a variety of vascular embolization materials for interventional use, mainly including polyvinyl alcohol (PVA) microspheres, sodium alginate microspheres, gelatin sponge, surgical wire, stainless steel coils, platinum microcoils, Detachable balloon, Cyanoacrylates, dehydrated ethanol, iodized oil, sodium morrhuate, etc. In clinical use, spring steel coils, surgical wires, and gelatin sponge have good clinical effects when plugging large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation. Liquid embolic agents such as Cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to embolism in clinical operations and difficult to operate. Polyvinyl Alcohol (PVA), sodium alginate mic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/18A61L31/06
Inventor 李艳芳周泰立
Owner 李艳芳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com