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Compound dandelion dripping pills and its preparing method

A technology of dropping pills and Gongying, which is applied in the field of compound Gongying dropping pills and its preparation, can solve the problems of affecting the full effect of the drug, low bioavailability, and long disintegration time limit, and achieves benefits for labor protection, environmental protection, and biological utilization. High degree, beneficial to the effect of GMP management

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.

Method used

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  • Compound dandelion dripping pills and its preparing method
  • Compound dandelion dripping pills and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Take 2000g of dandelion and 2000g of Radix Radix, add water and decoct twice, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 2 hours for the first time, 1.5 hours for the second time, Combine the decoctions, let stand for 12 hours, filter, concentrate the filtrate to an extract with a relative density of 1.15-1.25 (60°C), add ethanol to make the alcohol content 65%, stir evenly, let stand for 24 hours, and take the supernatant Ethanol is recovered from the liquid, concentrated into an extract, and the extract is vacuum-dried to obtain an extract. Take the extract, crush it, and pass through a 100-mesh sieve. Dandelion, Radix Radix Extract by Weight: Polyethylene Glycol 6000 = 1:2 ratio, add to the melted base (87°C), stir evenly, drop into simethicone coolant (4°C), separate drop pills, absorb the coolant, dry to obtain.

Embodiment 2

[0020] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves. Dandelion, Radix Radix Radix extract by weight: the ratio of mixed matrix=1:2 (mixed matrix is ​​polyethylene glycol 4000 : polyethylene glycol 6000 According to the formula of 1:4), add it into the melted matrix (87°C), stir evenly, drop into the simethicone coolant (4°C), separate the dripping pills, absorb the coolant, and dry to obtain.

Embodiment 3

[0021] Example 3: In this example, dandelion, Radix isatidis extracts and different matrix formulations are used to investigate indicators such as roundness, pill weight difference, hardness, and dissolution time, so as to determine the weight ratio of the extract to a single or mixed matrix.

[0022] The test of dandelion, Radix isatidis extracts and different matrix formulations (extracts are 1 part)

[0023] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0024] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio of extract to matrix is ​​1:1-1:2....

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PUM

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Abstract

A dripping pill of dandelion herb for treating upper respiratory tract infection, sore, furuncle, enteritis, etc is prepared from dandelion herb. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a compound Gongying dripping pill and a preparation process thereof. Background technique [0002] Dandelion, also known as Huanghuadiding, is the dry whole herb of Taraxacum mongolicum Hand.-Mazz., Taraxacum sinicum Kitag. or several plants of the same genus, and is widely distributed throughout the country. Dandelion is cold in nature, sweet and bitter in taste, has the functions of clearing heat and detoxifying, reducing swelling and dispelling stagnation, diuresis and treating stranguria. Modern medical research has proved that dandelion can enhance the immune function of the human body, and has antibacterial, anti-inflammatory, antiviral, and choleretic effects. Banlangen is the dried root of Isatis indigotica Fort., a cruciferous plant, and is mainly produced in Hebei, Anhui, Henan, Shaanxi, Gansu, Zhejiang, Jiangsu and other provi...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61K36/288A61K9/20A61P11/00A61P1/12A61P11/04A61P17/02
Inventor 陈茜滕慧丽
Owner 陈茜
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