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Anti-influenza dripping pills containing cottonrose hibiscus leaf, and its preparing method

An anti-influenza and dripping pill technology, applied in the directions of pill delivery, antiviral agents, pharmaceutical formulations, etc., can solve problems such as affecting the full play of drug efficacy, low bioavailability, and long disintegration time, and achieve the benefits of labor protection and safety. Environmentally friendly, high bioavailability, beneficial to GMP management

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Anti-influenza dripping pills containing cottonrose hibiscus leaf, and its preparing method
  • Anti-influenza dripping pills containing cottonrose hibiscus leaf, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Get 5000g of hibiscus leaves, add water to decoct twice, add water amount for the first time 8 times, second time 6 times, decoct for 1 hour each time, combine the decoction, let stand for 12 hours, filter, Concentrate the filtrate to an extract with a relative density of 1.13-1.23 (60°C), add ethanol to make the alcohol content 60%, stir evenly, let it stand, filter, recover ethanol from the filtrate, concentrate it into an extract, and vacuum dry the extract Or spray-dried extract. Take the extract, crush it, and pass through a 100-mesh sieve. Hibiscus leaf extract by weight ratio: polyethylene glycol 6000 =1:2.5 ratio, add to the melted matrix (90°C), stir evenly, drop into simethicone coolant (4°C), separate drop pills, absorb the coolant, dry to obtain.

Embodiment 2

[0018] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves. Hibiscus leaf extract by weight: the ratio of mixed matrix=1:2 (mixed matrix is ​​polyethylene glycol 6000 : poloxamer according to the formula of 1:0.3), add to the melted mixed matrix (87 ℃), stir evenly, drop into the simethicone coolant (4 ℃), separate the dropping pills, absorb and cool Agent, dry, that is.

Embodiment 3

[0019] Example 3: In this example, through the formulation of hibiscus leaf extract and different matrixes, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated to determine the weight ratio of the extract to a single or mixed matrix.

[0020] Experiments on hibiscus leaf extract and different matrix formulations (1 part for both extracts)

[0021] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0022] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio of extract to matrix is ​​1:1-1:2.

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PUM

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Abstract

A dripping pill of cottonrose hibiscus for treating influenza is prepared from cottonrose hibiscus. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a hibiscus anti-influenza dripping pill and a preparation process thereof. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus. Influenza can cause upper respiratory infections, pneumonia, and a variety of illnesses outside the respiratory tract. If the influenza virus invades the organs, it can cause serious complications, such as pneumonia, bronchitis, congestive heart failure, gastroenteritis, fainting, etc. The consequences are very serious. Influenza is very harmful to humans, and an influenza epidemic can lead to a reduction in the average life expectancy of the population. So far, five major epidemics and several small epidemics have occurred in the world, causing billions of people to become ill and tens of millions of people to die, seriously affecting people's lives and s...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/20A61P31/16
Inventor 陈茜滕慧丽
Owner 陈茜
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