Application of diosgenin in preparing medicine with synergistic attenuation

Abstract

The invention relates to the application of diosgenin in the preparation of drugs with synergistic and attenuating effects on chemotherapeutic drugs. It belongs to the new medicinal use of diosgenin. Diosgenin has synergistic and attenuating effects on chemotherapy drugs in the treatment of human melanoma, human cervical cancer, human gastric cancer and human breast cancer. When diosgenin is used in combination with chemotherapeutic drugs, it has enhanced anti-tumor effect and strong attenuation and synergistic effects. It not only reduces the dosage of chemotherapy drugs, but also reduces the toxic and side effects of chemotherapy drugs on tumor patients to some extent. Thus, the application population can be expanded, thereby generating better social and economic benefits.

Description

technical field [0001] The invention belongs to the new medicinal use of diosgenin. Background technique [0002] Diosgenin (Dio for short) is an active ingredient extracted from the rhizome of Dioscorea anipponica Makino. In recent years, many scholars at home and abroad have reported that dioscin has anti-tumor effects. [0003] Chemotherapy is currently one of the main means of treating malignant tumors. Pentafluorouracil (5-Fu), paclitaxel (Paclitaxel), and tegafur tablets (FT-207) are commonly used chemotherapeutic drugs. [0004] 5-Fluorouracil (5-Fluorouracil 5-Fu), dosage form, injection, used for digestive tract tumors, breast cancer, ovarian cancer, lung cancer, cervical cancer, etc. Usage: intravenous injection, intravenous infusion, side effects such as oral ulcers and diarrhea. [0005] Tegafur, (Tegafur, furanfluridine, furan fluorouracil, Fangke), dosage form, tablet, injection, is used for the treatment of gastric cancer, breast cancer, intestinal cancer a...

AI Technical Summary

Problems solved by technology

[0009] The low immune function of the body can lead to the occurrence of various diseases. A variety of tumors seen in clinical practice are often accompanied by low immune function. Many drugs, especially tumor chemotherapy drugs, often limit their application due to low immune function. Chemotherapy as a treatment for malignant tumors The main treatment method is to insist on time and sufficient amount is an important factor in the treatment, and the side effects caused by chemotherapy, such as leukopenia and immune function reduction, while inhibiting or killing tumor cells, also bring greater toxicity to the body Effects, the most common are gastrointestinal reactions and myelosuppression, which often affect the treatment and limit the full dose to affect the curative effect

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