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Effervescence tablet for wind-cold type cold

A cold-clearing and effervescent tablet technology, applied in antipyretics, anti-infectives, plant raw materials, etc., can solve problems such as increased cost, production, transportation, carrying, inconvenient use, and restrictions on the application of traditional Chinese medicine effervescent agents

Inactive Publication Date: 2009-10-07
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When traditional Chinese medicine is made into an effervescent dosage form, water extraction and alcohol extraction are usually used to obtain a variety of mixed macromolecular effective substances, including pectin, sugars, polysaccharides and other viscous substances. The disintegration is affected by viscous substances, and the disintegration is slow. On the other hand, in order to ensure the curative effect, the single-tablet Chinese medicine effervescent dosage form is taken in a large amount, which also affects the disintegration speed. In order to ensure disintegration, the excipients have to be increased The dosage makes some effervescent tablets need to be 4-5g / tablet, which not only increases the cost, but also brings inconvenience to production, transportation, carrying and use
The disintegration speed of traditional Chinese medicine effervescent preparations is as long as several minutes, and the advantages are not prominent compared with traditional Chinese medicine granules, which limits the application of traditional Chinese medicine effervescent preparations

Method used

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  • Effervescence tablet for wind-cold type cold
  • Effervescence tablet for wind-cold type cold
  • Effervescence tablet for wind-cold type cold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Preparation of cold and heat-clearing extract: Take 200 parts of nepeta panicles, 60 parts of mint, 100 parts of Fangfeng, 100 parts of Bupleurum, 60 parts of perilla leaves, 100 parts of kudzu root, 60 parts of bellflower, 80 parts of bitter almond, 60 parts of Angelica dahurica 200 parts, 200 parts of Kudiding, 160 parts of reed root, a total of eleven flavors. Extract volatile oil from nepeta ears, mint, and perilla leaves, and collect the distilled aqueous solution in another device; decoct the medicinal residues and other eight flavors such as Fangfeng with water twice, each time for 1.5 hours, combine the decoctions, filter, and the filtrate is mixed with the above The aqueous solutions were combined. Concentrate the combined solution under reduced pressure to a medicinal solution with a relative density of 1.08-1.10 (55°C), spray dry it, and make a dry extract powder, take the dry extract powder, add a small amount of dextrin to wrap the above volatile oil, an...

Embodiment 2

[0067] 1. Preparation of cold and heat-clearing extract: same as Example 1.

[0068] 2. Ganmao Qingre Ring-shaped Effervescent Tablets (100 Tablets)

[0069] Formula ratio:

[0070] Ganmao Qingre Extract 95g Tartaric Acid 150g

[0071] Cyclamate 5g essence 2g

[0072] Sodium bicarbonate 80g PEG 40005g

[0073] Crospovidone 30g PVP 33g

[0074] 3. Preparation method

[0075] The cold and heat-clearing extract obtained by drying is sealed and stored for later use; the tartaric acid, sodium bicarbonate, and microcrystalline cellulose are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; cyclamate and essence are crushed through a 100-mesh sieve, and PEG 4000 is crushed through a 140-mesh sieve Sieve; during the preparation process, control the environmental temperature of the preparation at 25°C and the humidity below 45%; mix the Ganmao Qingre extract and tartaric acid evenly according to the required ratio, then add cyclamate and essence a...

Embodiment 3

[0078] 1. Preparation of cold and heat-clearing extract: same as Example 1.

[0079] 2. Prepare Ganmao Qingre Ring-shaped Effervescent Tablets (100 tablets)

[0080] Formula ratio:

[0081] Ganmao Qingre Extract 65g, Malic Acid 40g, Citric Acid 115g

[0082] Aspartame 5g Acesulfame K 3g Flavor 2g

[0083] Sodium bicarbonate 30g Potassium carbonate 90g

[0084] Cross-linked polyvinylpyrrolidone 35g Magnesium stearate 15g

[0085] 3. Preparation method

[0086] The cold and heat-clearing extract obtained by drying is sealed and stored for later use; malic acid, citric acid, sodium bicarbonate, potassium carbonate, and cross-linked polyvinylpyrrolidone are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; acesulfame potassium and essence are crushed through 100 mesh Mesh sieve, magnesium stearate is crushed through a 140 mesh sieve; during the preparation process, the ambient temperature of the preparation is controlled at 25°C and the humidit...

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Abstract

The invention relates to a Ganmao Qingre effervescent tablet, in particular to a ring-shaped Ganmao Qingre effervescent tablet. The medicine of the present invention uses Nepeta panicle, Mint, Fangfeng, Bupleurum, perilla leaf, Pueraria lobata, Platycodon grandiflorum, bitter almond, Angelica dahurica, Kudiding and reed rhizome as raw materials to prepare cold and heat-clearing effervescent tablets. Dispelling wind and cold, relieving exterior and clearing heat, it is used for wind-cold and cold, headache and fever, aversion to cold and body pain, runny nose, cough and dry throat, improves bioavailability, and has the characteristics of easy oral administration, small dosage, and easy to carry. The preferred auxiliary materials and the ring-shaped effervescent tablet of the present invention can make the Ganmaoqingre effervescent tablet disintegrate rapidly.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine effervescent tablets, in particular to Ganmao Qingre effervescent tablets. Background technique [0002] At present, the main effervescent tablets in my country are health care products, such as vitamin C, calcium supplement effervescent tablets, and effervescent tablets for gynecological external use, such as Jieeryin effervescent tablets, metronidazole vaginal effervescent tablets, etc. But oral Chinese medicine effervescent preparations are less. And cold-clearing and heat-clearing formula is made into the effervescent tablet of oral pure Chinese medicine preparation, seldom report. In addition, annular tablets have been used in the food industry for a long time, but they are rarely used in the field of medicine, especially in the field of effervescent tablet preparation, and there are few reports. [0003] Traditional Chinese medicine effervescent tablet is a new dosage form, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K9/20A61K36/899A61K36/736A61P29/00A61P31/00A61P11/02A61P11/04
Inventor 罗晓健杨世林吕爱平王跃生魏惠珍周焘游剑
Owner JIANGXI HERBFINE HI TECH
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