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Erigeron breviscapus oral caving fast disintegration tablet and its preparation method

A technology of disintegrating tablets and scutellaria breviscapus, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of shortening drug dissolution time, achieve shortening drug dissolution time, good practical application value, and preparation The effect of simple process

Inactive Publication Date: 2009-09-09
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a rapidly disintegrating tablet of breviscapine and its preparation method. For patients, especially for stroke, hemiplegia patients and bedridden patients who have difficulty swallowing, the extract of breviscapine is prepared into an oral rapidly disintegrating dosage form , the patient only needs to put the disintegrating tablet into the mouth, and the tablet can be disintegrated into a suspension in the oral cavity without swallowing, chewing, sucking, etc., which is convenient for administration and shortens the dissolution time of the drug. Helps the drug take effect quickly

Method used

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  • Erigeron breviscapus oral caving fast disintegration tablet and its preparation method
  • Erigeron breviscapus oral caving fast disintegration tablet and its preparation method
  • Erigeron breviscapus oral caving fast disintegration tablet and its preparation method

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Effect test

Embodiment 1

[0027] The tablets were prepared by direct compression process. Components are shown in Table 1

example 1

[0028] Table 1 Prescription of breviscapine orally rapidly disintegrating tablets Case 1

[0029]

[0030]

[0031] Tablets are prepared as follows:

[0032] All adjuvants are dried and sieved; the active ingredient is mixed with all adjuvants except magnesium stearate in a dry mixer, and then the magnesium stearate is further mixed in to obtain a molded object.

[0033] The compression molding material is pressed into tablets with a Φ10 mold (shallow arc).

[0034] The tablet that this example makes, sheet diameter 10mm, sheet thickness 4.5mm, sheet weight difference is below 3%. The hardness of the obtained tablet is 50-60N. The disintegration time limit is 20-30 seconds, and it can disintegrate in the mouth within 30 seconds, and the friability is less than 1% measured according to the Chinese Pharmacopoeia standard.

Embodiment 2

[0036] The tablets were prepared by direct compression process. Components are shown in Table 2

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Abstract

The orally rapidly disintegrating tablet of scutellaria breviscapus and a preparation method thereof relate to an orally rapidly disintegrating tablet with scutellaria breviscapus extract as an active ingredient and a preparation method thereof. The tablet contains 5-20% active ingredient by weight, 2-10% disintegrant, 0.2-2% lubricant, 0.1-1.5% glidant and 0-0.5% additive, and the rest is fillers. The patient only needs to put the disintegrating tablet into the mouth without swallowing, chewing or sucking with water. The tablet disintegrates into a suspension within 60 seconds after contacting with saliva at the entrance; Works quickly. The tablet has ideal hardness and friability, and is convenient for packaging, storage and transportation; the preparation process is simple, suitable for industrial production, economical and feasible, and has good practical value.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine tablet, in particular to an orally rapidly disintegrating tablet with scutellaria breviscapus extract as an active ingredient and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique: [0002] Erigeron brevisca (Vant) Hand-Mass, the original plant of Erigeron brevisca (Vant) Hand-Mass. Erigeron breviscapus refers to the flavonoid extract extracted from Erigeron breviscapus, and scutellarin is a mixture of scutellarin and scutellarin extracted from scutellaria breviscapus. Pharmacological studies have shown that breviscapine extract (including breviscapine or breviscapine) has the effect of dilating cerebral blood vessels, can reduce cerebrovascular resistance, increase cerebral blood flow, improve microcirculation, and have the effect of resisting platelet aggregation. Good medicine for cardiovascular and cerebrovascular diseases. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/28A61K31/7048A61P9/10
Inventor 罗国安叶磊王义明
Owner TSINGHUA UNIV
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