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Ceftiofur-containing powder injection for beast

A technology of ceftiofur and ceftiofur hydrochloride, which is applied in the field of drugs for the prevention and treatment of animal microbial infectious diseases, and can solve the problems of high production cost and limited popularization and application of powder injections

Active Publication Date: 2009-09-02
浙江拜克生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the synthesis of ceftiofur, the synthetic yield from free acid to hydrochloride is reduced by 15-30%, and the synthetic yield from hydrochloride to sodium salt is reduced by 5-10%, and more expensive freeze-drying equipment is required etc., the production cost of preparing powder injection with sodium salt is high, which limits its popularization and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: 0.5g of ceftiofur hydrochloride is subpackaged in 5ml vials, and dimethylacetamide / triacetin (3:7) liquid dispersion is subpackaged in 2ml ampoules, used When injecting the liquid dispersion into a 5ml vial, shake it to prepare a solution. The solution is used in pigs, cattle, sheep and other animals to prevent and treat bacterial infectious diseases. It is injected subcutaneously. Pig 3-10mg ceftiofur hydrochloride / kg b.w., injected once every 24-72 hours.

Embodiment 2

[0038] Embodiment 2: ceftiofur hydrochloride 1g is subpackaged in 5ml vials, and 4ml of formaldehyde glycerol / 1,2-propanediol (1:1) containing 2% lidocaine and 5% polyvinylpyrrolidone The solutions are respectively packed in 5ml ampoules. When in use, the solution in the ampoules is injected into the cillin bottle equipped with ceftiofur hydrochloride, shaken to dissolve it, and is prepared into a 20% ceftiofur hydrochloride solution. The method of use is as described in Example 1.

Embodiment 3

[0039] Embodiment 3: 1 g of ceftiofur hydrochloride is subpackaged in 5 ml vials, and 4 ml of dimethylacetamide / trichlorobutanol containing 0.5% chlorobutanol and 1.5% ethyl cellulose (RT-20) Acetate glyceride (3: 7) solution is packed in 5ml ampoule respectively, when using, the dimethylacetamide / triacetin (3: 7) solution in the ampoule is taken out, injects into the ceftiofur In the cillin bottle of hydrochloride, shake, make it dissolve, prepare to contain 20% ceftiofur hydrochloride solution. Dosage: 3-10mg ceftiofur hydrochloride / kg b.w. for cattle and sheep, injected once every 48-96 hours; 5-10mg ceftiofur hydrochloride / kg b.w. for pigs, injected every 48-96 hours once.

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PUM

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Abstract

The invention relates to a veterinary powder injection containing ceftiofur, which belongs to the technical field of drugs for preventing and treating animal microbial infectious diseases. It is characterized in that it contains 20-100% by weight of ceftiofur free acid or ceftiofur hydrochloride aseptic powder, and the rest is medical auxiliary agent. The above-mentioned veterinary powder injection containing ceftiofur has good quick-acting and sustained-release effects, and adopts ceftiofur free acid or ceftiofur hydrochloride to prepare aseptic powder, which is lower than that of preparing powder injection with ceftiofur sodium. More than 20% of the production cost is conducive to its popularization and application. The injection is suitable for the prevention and treatment of animal microbial infectious diseases. When in use, the sterile powder is mixed with a liquid dispersant, prepared into a solution, solution suspension, suspension or emulsion, and injected subcutaneously or intramuscularly.

Description

technical field [0001] The invention belongs to the technical field of drugs for preventing and treating animal microbial infectious diseases, and specifically relates to a veterinary powder injection containing ceftiofur. Background technique [0002] Ceftiofur (ceftofur) is a semi-synthetic third-generation animal-specific cephalosporin, which has a broad-spectrum antibacterial effect and is effective against both Gram-positive and Gram-negative bacteria, including β-lactamase-producing strains. At present, there are very good water-soluble ceftiofur sodium powder injections, which are dissolved in sterile water and injected intramuscularly, with a dose of 1-5mg / kg b.w., administered once every 12-24 hours, and hydrochloric acid Ceftiofur is prepared as an oil suspension for subcutaneous or intramuscular injection. However, during the synthesis of ceftiofur, the synthetic yield from free acid to hydrochloride is reduced by 15-30%, and the synthetic yield from hydrochlorid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/14A61P31/04
Inventor 王玉万沈德堂储消和刘萍
Owner 浙江拜克生物科技有限公司
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