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Dispersion tablet of red sage root for coronary artery and preparation method thereof

A technology of Guanxin Danshen and dispersible tablets, which is applied in the field of Guanxin Danshen dispersible tablets and its preparation, can solve problems such as unsatisfactory drug efficacy, and achieve the effects of large drug advantage, fast absorption, and small adverse reactions

Active Publication Date: 2009-07-08
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Salvia miltiorrhiza contains many active ingredients, and it is only used as a liquid extract. The active ingredients extracted are mainly fat-soluble ingredients, and the efficacy is not ideal.

Method used

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  • Dispersion tablet of red sage root for coronary artery and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 0.9kg of Salvia miltiorrhiza, add 10kg of 95% ethanol to heat and reflux twice, each time for 2 hours, filter to obtain the reflux liquid of Salvia miltiorrhiza; The alcohol content reaches 60%, refrigerate for 24 hours, the refrigerated temperature is -10 ~ 4 ℃, filter, the filtrate recovers ethanol and concentrates, add ethanol to make the alcohol content reach 80%, refrigerate for 24 hours, the refrigerated temperature is -10 ~ 4 ℃, filtered, the filtrate was combined with the reflux liquid of Salvia miltiorrhiza, sprayed, concentrated and dried to obtain 250 g of Salvia miltiorrhiza extract. Take 0.9kg of Panax notoginseng and grind it into coarse powder, add 5kg of 70% ethanol and heat to reflux twice for 2 hours each time, combine the reflux liquid, filter, recover ethanol from the filtrate, spray, concentrate and dry to obtain 290g of Panax notoginseng extract. Take 75g of β-cyclodextrin, add 1000g of water to heat to dissolve, take 11g of balsam pear oil an...

Embodiment 2

[0030]Take 1 kg of Salvia miltiorrhiza, add 10 kg of 95% ethanol, heat and reflux twice, each time for 1.5 hours, filter to obtain the reflux liquid of Salvia miltiorrhiza; add 8 kg of water to decoct the filtered dregs twice, each time for 2.5 hours, add ethanol until it contains alcohol When the volume reaches 70%, refrigerate for 24 hours at a temperature of -10 to 4°C, filter, recover ethanol from the filtrate and concentrate it, add ethanol to make the alcohol content reach 85%, let it stand and refrigerate for 24 hours at a temperature of -10 to 4°C , filtered, and the filtrate was combined with the reflux liquid of Danshen, concentrated and dried in vacuo to obtain 275g of Danshen extract. Take 1 kg of Panax notoginseng and crush it into a coarse powder, add 6 kg of 80% ethanol and heat to reflux twice for 1.5 hours each time, combine the reflux liquid, filter, recover ethanol from the filtrate, concentrate and dry in vacuo to obtain 312 g of Panax notoginseng extract. ...

Embodiment 3

[0032] Take 1.2 kg of Salvia miltiorrhiza, add 12 kg of 95% ethanol, heat and reflux twice, each time for 1.5 hours, filter to obtain the reflux liquid of Salvia miltiorrhiza; The alcohol content reaches 70%, refrigerate for 24 hours, the refrigerated temperature is -10 ~ 4 ℃, filter, the filtrate recovers ethanol and concentrates, add ethanol to make the alcohol content reach 80%, stand refrigerated for 24 hours, the refrigerated temperature is -10 ~ 4 ℃, filtered, the filtrate was combined with the reflux liquid of Salvia miltiorrhiza, sprayed, concentrated and dried to obtain 300 g of Salvia miltiorrhiza extract. Take 1.2kg of Panax notoginseng and grind it into a coarse powder, add 5kg of 80% ethanol and heat to reflux twice for 2 hours each time, combine the reflux liquid, filter, recover ethanol from the filtrate, spray, concentrate and dry to obtain 330g of Panax notoginseng extract. Take 75g of β-cyclodextrin, add 1000g of water to heat to dissolve, take 11g of balsami...

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Abstract

The invention relates to a Guanxin Danshen dispersible tablet and a preparation method thereof. A Guanxin Danshen dispersible tablet is prepared by adding active ingredients Salvia miltiorrhiza, Radix Notoginseng, and balsamic oil, and adding auxiliary materials, wherein the active ingredient Salvia miltiorrhiza is boiled in water for alcohol precipitation, and the active ingredients are extracted by ethanol reflux; the active ingredients of Radix Notoginseng are extracted by ethanol reflux; Sesame oil is treated with β-cyclodextrin inclusion; the weight ratio of the active ingredients Salvia miltiorrhiza extract, Panax notoginseng extract, Dalbergia balm inclusion compound and its auxiliary materials is: Salvia miltiorrhiza extract 25-30, Sanqi extract 29-33 , balm clathrate 6-7, excipients 30-700. Salvia miltiorrhiza was heated and refluxed twice with ethanol to obtain the salvia miltiorrhiza reflux liquid, the medicinal dregs were decocted twice with water, refrigerated twice with ethanol, combined with the salvia miltiorrhiza reflux liquid, concentrated and dried to obtain the salvia miltiorrhiza extract; Sanqi was heated and refluxed with ethanol for two Concentrated and dried to obtain Panax notoginseng extract; Dilute balsamic oil with absolute ethanol, add β-cyclodextrin aqueous solution, stir and refrigerate, and obtain balsamic clathrate after drying; add excipients, dry press into tablets , to obtain Guanxin Danshen Dispersible Tablets.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, more specifically, to a Guanxin Danshen dispersible tablet and a preparation method thereof. Background technique [0002] Coronary miltiorrhiza is a pure Chinese medicine preparation made from three kinds of traditional Chinese medicines: Panax notoginseng, Danshen and Jiangxiang oil. Traditional Chinese medicine believes that Danshen is a blood-activating drug, which has the effects of promoting blood circulation, dissipating stasis, dredging menstrual flow, relieving numbness, reducing swelling, and relieving pain; modern pharmacological research shows that Danshen contains more than 10 compounds, among which sodium tanshinone IIA sulfonate can remove cellular Toxic oxygen free radicals and solubilization effects, anticoagulation, inhibition of platelet aggregation, inhibition of thrombosis and anti-lipid peroxidation; animal experiments have proved that the comb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/48A61K36/258A61K9/20A61P9/10
Inventor 张国清
Owner JIANGSU PENGYAO PHARMA
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