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Sulfonated dehydrogenated ferrous abietate, its preparation process and pharmaceutical use

A technology of ferrous hydroabietic acid and dehydroabietic acid, which is applied in the preparation of sulfonate, organic chemistry, drug combination, etc., can solve the problems of multiple reactions, pain, anaphylactic shock, etc., and achieve high activity and toxicity Low-cost, simple and easy-to-follow effect

Inactive Publication Date: 2009-06-10
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs for treating iron deficiency anemia mainly include ferrous sulfate and iron dextran injection; while ferrous sulfate patients with peptic ulcer and enteritis are contraindicated, the injection of iron dextran injection may cause local pain, headache, dizziness, Nausea, vomiting, diarrhea, severe cases may have anaphylactic shock, many and severe reactions

Method used

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  • Sulfonated dehydrogenated ferrous abietate, its preparation process and pharmaceutical use
  • Sulfonated dehydrogenated ferrous abietate, its preparation process and pharmaceutical use
  • Sulfonated dehydrogenated ferrous abietate, its preparation process and pharmaceutical use

Examples

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Comparison scheme
Effect test

Embodiment 1

[0034] A kind of sulfonated dehydroabietic acid ferrous salt, structural formula is:

[0035] or

[0036] Sulfonated dehydroabietic acid monoferrous salt Sulfonated dehydroabietic acid bisferrous salt.

[0037] The present invention is sulfonated dehydroabietic acid [chemical name: 7-isopropyl 1,4a-dimethyl-6-sulfo-1,2,3,4,4a,9,10,10a-eight Hydrophenanthrene-1-carboxy] monoferrous salt and sulfonated dehydroabietic acid bisferrous salt.

Embodiment 2

[0039] A method for preparing the ferrous sulfonated dehydroabietic acid salt described in Example 1 may be one of a displacement method, an acid-base neutralization method or a direct salt preparation method.

[0040] Wherein, the salt direct preparation method prepares dehydroabietic acid monoferrous salt, comprises the following steps:

[0041] In the first step, sulfonated dehydroabietic acid is dissolved in a solvent, wherein the weight of the solvent is 10 to 100 times that of sulfonated dehydroabietic acid, for example, it can be selected as 15 times, 20 times, 25 times, 30 times, 36 times, 42 times, 49 times, 55 times, 60 times, 65 times, 70 times, 80 times, 90 times, 95 times, the solvent is low carbon alcohol, water, dimethylformamide or dimethyl sulfoxide any of the

[0042] In the second step, the pH value of the system is adjusted to 2.4-5.0 with a strong alkali solution, and the pH value can be selected as 2.4, 2.6, 2.8, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8...

Embodiment 3

[0056] Application of sulfonated dehydroabietic acid ferrous salt in preparation of medicine for simultaneously treating gastric ulcer and iron deficiency anemia caused by chronic blood loss.

[0057] The dosage of sulfonated dehydroabietic acid ferrous salt in the present invention is generally determined according to the patient's condition, age, body weight, etc., and the general dosage is about 2mg / kg-350mg / kg, which is the best dosage for treating iron deficiency anemia 25mg / kg-100mg / kg, the best dosage for treating gastric ulcer is 30mg / kg-200mg / kg, and the best dosage for comprehensive treatment is 40-220mg / kg.

[0058] When the traditional Chinese medicine of the present invention is used as anti-gastric ulcer, peptic ulcer and iron-deficiency anemia, it can be taken orally or injected, preferably orally. The forms of medicines include pills, capsules, granules, etc., and pharmaceutical excipients such as starch and flavoring agents can be added at the same time.

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Abstract

The invention relates to a sulfonated dehydroabietic ferrous salt and preparation methods, and medical uses, belong to sulfonated dehydroabietic salts areas. Preparation method is one of the replacement, acid-base neutralization method and direct salt preparation. Direct salt Preparation includes follow steps: dissolve dehydroabietic sulfonated acid in solvent of alcohols, water, dimethyl formamide, or DMSO in any; regulating pH by alkali solution system; Join the ferrous salt for reaction 0.5 to 5 hours, solution concentration, filtration, obtain sulfonated dehydroabietic ferrous salt. The compounds have high activity in the anti-ulcer and gastritis, tiny side effects on the human body and also to supplement the body's iron. Preparation method is simple and low cost. Sulfonated dehydroabietic ferrous salt can be used to treat gastric ulcer, gastritis, gastric ulcers, iron deficiency anemia caused by chronic blood loss.

Description

technical field [0001] The invention relates to a sulfonated dehydroabietic acid salt, a preparation method and its medical application, in particular to a ferrous sulfonated dehydroabietic acid salt, a preparation method and its medical application. Background technique [0002] Peptic gastric ulcer is an ulcer disease caused by the digestion of gastric acid and pepsin. It mainly occurs in the stomach and duodenum. This type of disease is prone to repeated attacks and can easily cause cancer. Commonly used therapeutic drugs include antacid sodium bicarbonate and aluminum phosphate, anti-secretion drugs gastrin, cimetidine, ranitidine, gastric mucosal protective agent sucralfate, compound bismuth subnitrate, teprenone, Prokinetic drugs metoclopramide, domperidone, mosapride, etc. Excessive use of antacids can easily cause hypoacidity in the stomach, thereby significantly reducing the digestive activity of pepsin and causing indigestion; gastric mucosal protective agents suc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C309/58C07C303/32A61K31/185A61P7/06
Inventor 宋湛谦韩春蕊商士斌
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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