Medicine for treating gout and gout arthritis

An arthritic and drug technology, applied in the field of oral pharmaceutical composition and preparation thereof, can solve the problems of difficulty in taking it continuously, inability to take it, serious toxic and side effects in patients and the like

Active Publication Date: 2008-12-17
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, chemical drugs are mainly used in the treatment of this disease at home and abroad. Although these most commonly used therapeutic drugs have relatively reliable curative effects, they all have relatively serious side effects. Contraindications, inability to take or difficulty continuing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the tablet preparation of medicine of the present invention

[0015] Take the following traditional Chinese medicine raw materials: betel nut 310g, epimedium 230g, atractylodes 110g, coix seed 140g, silkworm excrement 210g, tangerine peel 90g, bellflower 50g, add 4 times the amount of water to distill for 6 hours to extract aromatic water for all medicinal materials, and filter Pass. Decoct the medicinal dregs twice, adding 7 times the amount of water each time, for 1.5 hours each time. The residue was filtered off, the above filtrates were combined, and concentrated under reduced pressure to a relative density of 1.14 (60°C). Add ethanol to make the alcohol content reach 60%, and let stand overnight. Filtrate, recover ethanol from the filtrate, add water to the concentrated solution to 410ml, adjust the pH to 6-7 with NaOH, refrigerate, filter, concentrate the filtrate under reduced pressure, combine aromatic water after spray drying, add appropriate am...

Embodiment 2

[0016] Embodiment 2: the mixture preparation of medicine of the present invention

[0017] Take the following traditional Chinese medicine raw materials: betel nut 320g, epimedium 230g, atractylodes 95g, coix seed 155g, silkworm sand 195g, tangerine peel 85g, bellflower 55g, turmeric 80g, evodia 35g, ginger 105g, add 5 times the amount of water distillation for all medicinal materials Extract the aromatic water for 4 hours, and filter the liquid medicine. Decoct the dregs twice, adding 8 times the amount of water each time, for 1 hour each time. The residue was filtered off, the above filtrates were combined, and concentrated under reduced pressure to a relative density of 1.15 (60°C). Add ethanol to make the alcohol content reach 65%, and let stand overnight. Filtrate, recover ethanol from the filtrate, add water to the concentrated solution to 400ml, adjust the pH to 6-7 with 10% NaOH, refrigerate, filter, and combine the filtrate with aromatic water. Add 100g of glycerin...

Embodiment 3

[0018] Embodiment 3: the granule preparation of medicine of the present invention

[0019] Take the following traditional Chinese medicine raw materials: betel nut 325g, epimedium 225g, atractylodes 105g, coix seed 155g, silkworm excrement 205g, tangerine peel 85g, bellflower 55g, turmeric 85g, perilla leaf 75g, papaya 75g, add 6 times the amount of all medicinal materials Water distilled for 5 hours to extract aromatic water, and the medicinal solution was filtered. Decoct the dregs twice, adding 8 times the amount of water each time, for 1 hour each time. The residue was filtered off, the above filtrates were combined, and concentrated under reduced pressure to a relative density of 1.16 (60°C). Add ethanol to make the alcohol content reach 65%, and let stand overnight. Filtrate, recover ethanol from the filtrate, add water to the concentrated solution to 400ml, adjust the pH to 6-7 with NaOH, refrigerate, filter, concentrate the filtrate under reduced pressure, combine ar...

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Abstract

The invention relates to an oral pharmaceutical composition and a preparation method thereof. The medicine of the invention contains raw materials of traditional Chinese medicines such as epimedium, coix seed, tangerine peel, perilla leaf and papaya. After filtering for several times, the filtrate is combined with aromatic water and auxiliary materials to make different preparations. The medicament of the present invention can remove dampness and dredge collaterals, relieve numbness and relieve pain, and is used for relieving swelling and pain of toe-metatatars joints caused by gout caused by dampness. In addition, the pharmacodynamic test proves that the medicine of the present invention can inhibit the paw swelling of rats caused by sodium urate crystals (MSU), can significantly reduce the leukocytes in the joint fluid of MSU-induced acute arthritis in rabbits, and can significantly inhibit Carrageenan-induced rat paw swelling and xylene-induced mouse ear swelling, and can significantly inhibit the formation of rat granuloma.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition and a preparation method thereof, in particular to an oral medicine for treating gout and acute gouty arthritis, which is produced and prepared with traditional Chinese medicine as the main raw material and modern preparation technology. Background technique [0002] Modern medicine refers to a disease of gout, which belongs to the category of arthralgia in traditional Chinese medicine. The etiology has two aspects, internal and external. The internal cause is mostly due to insufficient congenital endowment, or aging viscera, or the habit of eating fat, sweet and thick flavors, resulting in dysfunction of the viscera, especially the disorder of the clear and turbid ascending and descending of the spleen and kidney. Gasification, damp and turbid phlegm and saliva will be born thereupon. Externally, the wind-cold-damp pathogen takes advantage of the deficiency to attack, blocks the meridians, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/8994A61K9/00A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61P19/06A61P19/02
Inventor 张沛冯华祥张林
Owner SICHUAN SUNNYHOPE PHARM CO LTD
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