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Method for continuous hypothermal desiccation and sterilization of bony tissue, and equipment therefor

A technology for drying and sterilizing bone tissue, applied in water supply devices, drying solid materials, drying solid materials by heating, etc. It can solve the problems of unstable bone tissue quality, limited irradiation base, and great influence on the biological activity of transplanted bone. , to reduce microbial contamination and clinical infection, facilitate popularization and application, and maintain the effect of biological activity

Inactive Publication Date: 2008-11-05
王立飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a conventional treatment method for bone tissue for transplantation, there are mainly the following problems in the implementation process of this method: 1. The discontinuity of the method-after the bone tissue is technically processed, it needs to be freeze-dried first, and then irradiated at low temperature. Bacteria, each step takes a long time, and requires strict aseptic operation to prevent microbial infection and affect the quality of bone tissue heat source; High; radiation sterilization is also limited by the limitation of irradiation bases and shortage of resources, which affects the popularization and application of bone grafting technology; 3. The instability of bone tissue quality - such as the use of gamma ray radiation Tissues need to strictly control the dosage and time of irradiation, and high dosage will affect the biological activity of bone tissue
In addition to radiation sterilization methods, there are also chemical sterilization and heat sterilization methods, but there are problems such as great impact on the biological activity of grafted bone, chemical residues, unstable sterilization effect and complicated process.

Method used

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  • Method for continuous hypothermal desiccation and sterilization of bony tissue, and equipment therefor
  • Method for continuous hypothermal desiccation and sterilization of bony tissue, and equipment therefor
  • Method for continuous hypothermal desiccation and sterilization of bony tissue, and equipment therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] a) The donor bone tissue is processed in a clean operating room according to surgical techniques, bone marrow is removed, fat and protein are cleaned and removed, and antibacterial packaging is carried out in a special packaging bag;

[0032] b) placing the bone tissue processed in step a) on the shelf in the closed container 1;

[0033] c) close the closed door 2, start the vacuum pump 3 to evacuate, so that the vacuum pressure of the closed container 1 is controlled at 0.1Pa; maintain for 5 minutes to achieve the purpose of drying the bone tissue;

[0034] d) Pass argon gas and peroxide gas into the closed container 1, and maintain the vacuum pressure in the container at 0.1Pa;

[0035] e) After passing through the above-mentioned gas, feed electromagnetic waves in the closed container 1, the frequency of the electromagnetic waves is 300KHz; its voltage is 100V, and the power is 50W, so that the gas in the working room is ionized, and then forms plasma, and the contai...

Embodiment 2

[0038] a) The donor bone tissue is processed in a clean operating room according to surgical techniques, bone marrow is removed, fat and protein are cleaned and removed, and antibacterial packaging is carried out in a special packaging bag;

[0039] b) placing the bone tissue processed in step a) on the shelf in the closed container 1;

[0040] c) close the closed door 2, start the vacuum pump 3 to evacuate, so that the vacuum pressure of the closed container 1 is controlled at 1000Pa; maintain for 60 minutes to achieve the purpose of drying the bone tissue;

[0041] d) Pass oxygen and peroxide gas into the closed container 1, and maintain the vacuum pressure in the container at 1000Pa;

[0042] e) After passing through the above-mentioned gas, feed electromagnetic waves into the closed container 1, the frequency of the electromagnetic waves is 8MHz; its voltage is 5000V, and the power is 5000W, so that the gas in the working room is ionized, and then forms plasma, which can i...

Embodiment 3

[0045] a) The donor bone tissue is processed in a clean operating room according to surgical techniques, bone marrow is removed, fat and protein are cleaned and removed, and antibacterial packaging is carried out in a special packaging bag;

[0046] b) placing the bone tissue processed in step a) on the shelf in the closed container 1;

[0047] c) close the closed door 2, start the vacuum pump 3 to evacuate, so that the vacuum pressure of the closed container 1 is controlled at 500Pa; maintain for 30 minutes to achieve the purpose of drying the bone tissue;

[0048] d) Pass inert gas into the closed container 1, and maintain the vacuum pressure in the container at 500Pa;

[0049] e) After passing through the above-mentioned gas, feed electromagnetic waves into the closed container 1, the frequency of the electromagnetic waves is 13.56MHz; its voltage is 2500V, and the power is 2500W, so that the gas in the working room is ionized to form plasma, and the container can be The b...

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Abstract

A method for continuous low-temp drying and sterilizing of the bone tissue used for transplanting or repairing purpose includes such steps as processing the bone tissue in cleaned operation room, putting it on a holder in a sealed container, vaccuumizing to 0.1-1000 Pa for 5-60 min, filling argon or oxygen or inertial gas or hydrogen peroxide vapor under said vacuum deg., and applying electromagnetic waves for 5-30 min.

Description

technical field [0001] The invention relates to a method for continuous low-temperature drying and sterilization of bone tissue and a device for implementing the method. It is suitable for clinical orthopedic transplantation and repair surgery. Background technique [0002] Bone tissue is also called bone graft, bone graft, bone material, etc., and is used for clinical orthopedic transplantation and repair surgery. Infection or infectious disease infection from allograft bone grafting in the hospital is a serious complication and unexpected event. Therefore, in order to reduce the risk of HIV and other infectious diseases transmitted by bone tissue during transplantation, the clinical methods currently used in hospitals are: to carefully investigate and screen the medical history of bone tissue donors in accordance with relevant international standards, and to conduct a thorough investigation and screening of bone tissue donors in a clean room of a specified level. Surgica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L2/14F26B3/04A61F2/28
Inventor 王立飞
Owner 王立飞
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