Methylnaphthohydroquinone diphosphate sodium tablet and its preparing method

Abstract

This invention relates to a menadiol sodium-diphosphare tablet and preparing method thereof. In which 2-methyl-1, 4-hydronaphthoquinone is used as raw material which is processed through reduction, phosphorylation etc.to obtain 2-methyl-1,4-naphthohydroquinone di-tetra-sodium-salt hexahydrate, then according normal pharmaceutical method to prepare menadiol sodium-diphosphare tablets. By proof test, the gain rate of the menadiol sodium-diphosphare can be up to 92.5%, purity can be up to 99.7% which are fully suitable to the following pharmaceutical processes.

Description

Technical field [0001] The invention relates to a menadione hydroquinone diphosphate sodium tablet and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] The molecular formula of menadione hydroquinone diphosphate sodium is: C 11 H 8 Na 4 O 8 P 2 ·6H 2 O, molecular weight 530.17, chemical name: 2-Methyl-1,4-naphthalenehydroquinone bis(dihydrophosphate) tetrasodium salt hexahydrate, English name: 2-Methyl-1,4-naphthalenediolbis( dihydrogen phosphate)tetrasodium salt, hexahydrate, its chemical structure is: [0003] [0004] Menadione diphosphate sodium is vitamin K 3 The artificial synthetic product of the body is converted into menadione (vitamin K 3 ). It is the same as vitamin K that exists in nature. Vitamin K is an essential substance for the liver to synthesize prothrombin (factor II), and it is also involved in the synthesis of factor VII, factor IX and factor X. Lack of vitamin K can cause the above-mentio...

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Problems solved by technology

[0011] 2. For some patients with exacerbated jaundice, the use of this product may cause passive prothrombin levels during the administration period, resulting in drug-induced hysteresis and fluctuating reactions, and sometimes symptoms such as high fever, vomiting or hunger may occur

[0012] 3. Among the patients with liver damage, the rise of thrombin level has obvious lag after administration. Some patients, such as patients with liver disease who are infected at the same time, have not been able to reach the 100% level. In individual cases, once the drug is stopped, other Thrombin levels could not be maintained, patients with pyloric disorders or after colostomy surgery and patients with severe sepsis and starvation showed the same drug response as patients with liver dysfunction

[0013] 4. In many cases of patients with jaundice and sepsis, the prothrombin level can only reach the normal level after 96 hours, but in these cases, the normal prothrombin level is still maintained at 48 hours after stopping the drug Phenomenon

They have impaired absorption of vitamins and do not respond quickly, incompletely, and for short periods to medications

[0015] However, as long as the integrity of liver function is not severely compromised, the disturbance in trypanin K absorption seen in certain gastrointestinal diseases and sepsis leading to hypothrombin symptoms occurs only after the disturbance persists for a period of time In most cases, patients with colitis complicated with peptic ulcer can often lead to long-term vitamin K deficiency, but because patients have long-term intake of trace amounts of this substance from food, their thrombin levels can still be close to normal, but in Significantly lower prothrombin levels are almost always found in cases of liver tissue injury

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