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Polymer/graphite oxide anticoagulant nano composite material and preparation method thereof

A composite material and polymer technology, which is applied in the field of polymer/graphite oxide nano anticoagulant composite material and its preparation, can solve the problems that nano powder is not easy to disperse evenly, the mechanical properties of materials are affected, and there are no literature and patent reports. , to achieve the effect of prolonged anticoagulant performance, good sustained release performance, good biocompatibility and blood compatibility

Inactive Publication Date: 2008-02-27
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There are patent reports on the anticoagulant properties of heparin-quaternary ammonium salt complexes at home and abroad, such as US2002150670A1, JP2000288081A2, CN1448144A, but heparin-quaternary ammonium salt complexes are inserted as functional intercalants between graphite oxide layers to form functional anticoagulation Blood intercalation agent-graphite oxide nano-intermediate, and further synthesis of polymer / graphite oxide-heparin-quaternary ammonium salt nano-anticoagulant composite material and its preparation method have not been reported in literature and patents
[0011] In addition, the synthesis of some anticoagulant materials is mostly to dope nano-powders (such as metal oxide nano-powders CN1454671A, nano-carbon) into polymers to form "doped polymers". It is not easy to disperse evenly in the film; so the dispersion and compatibility between nanopowder and polymer need to be further improved
[0012] In short, so far, there is no modified medical anticoagulant material that can fully meet the high requirements of the current clinical application of the cardiovascular system, such as making small-caliber vascular grafts, fully implantable artificial hearts, etc.
In addition, most of the current modification methods (such as various surface grafting modifications) will have a certain negative impact on the mechanical properties of the material while improving the blood compatibility of the material.

Method used

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  • Polymer/graphite oxide anticoagulant nano composite material and preparation method thereof
  • Polymer/graphite oxide anticoagulant nano composite material and preparation method thereof
  • Polymer/graphite oxide anticoagulant nano composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1, referring to Figures 1 to 3, and Figures 4-1 and 4-2:

[0055] Dissolve 0.01 part of graphite oxide in 2 mL of 0.1M NaOH solution (equivalent to 0.0002 parts of NaOH), and ultrasonically treat it for 20 minutes to obtain a black colloid; Add 0.3 parts of the ammonium complex to the graphite oxide colloidal solution treated with NaOH at 20-60°C, and ultrasonicate for 15 minutes to obtain a black precipitate; filter the precipitate and wash it with distilled water until no chloride ions can be detected (use 0.2% AgNO 3 solution detection); vacuum drying at 60°C for 24 hours, the resulting black solid is pulverized into a functional graphite oxide / heparin-quaternary ammonium salt anticoagulant complex;

[0056] Disperse 0.01 part of the above-mentioned functional graphite oxide / heparin-quaternary ammonium salt anticoagulant compound in 100 parts of dispersion medium toluene at 20-60 °C, add 100 parts of room temperature vulcanized silicone rubber, and stir vi...

Embodiment 2

[0058] Dissolve 10 parts of graphite oxide in 500 mL of 0.1 M NaOH (equivalent to 0.05 parts of NaOH) solution, and ultrasonically treat it for 2 hours to obtain a black colloid; Add 20 parts of the ammonium chloride complex into the graphite oxide colloid solution treated with NaOH at 20-60°C, and ultrasonicate for 30 minutes to obtain a black precipitate; filter the precipitate and wash it with distilled water until no chloride ions can be detected (with 0.2% AgNO 3 solution detection); vacuum drying at 60°C for 24 hours, the resulting black solid is pulverized into a functional graphite oxide / heparin-quaternary ammonium salt anticoagulant complex;

[0059] Disperse 10 parts of the above-mentioned functional graphite oxide / heparin-quaternary ammonium salt anticoagulant compound in 200 °C dispersion medium xylene at 20-60 °C, add 100 parts of room temperature vulcanized silicone rubber, and stir vigorously for 6 hours to make it Mix well, add 5 parts of anilinomethyltrimetho...

Embodiment 3

[0061] Dissolve 2 parts of graphite oxide in 60mL of 0.1M NaOH (equivalent to 0.006 parts of NaOH) solution, and ultrasonically treat it for 1 hour to obtain a black colloid; functional anticoagulant intercalation agent heparin sodium-octadecyltrimethyl Add 1 part of the ammonium chloride complex to the graphite oxide colloid solution treated with NaOH at 20-60°C, and ultrasonicate for 20 minutes to obtain a black precipitate; filter the precipitate and wash it with distilled water until no chloride ions can be detected (with 0.2% AgNO 3 solution detection); vacuum drying at 60°C for 24 hours, the resulting black solid is pulverized into a functional graphite oxide / heparin-quaternary ammonium salt anticoagulant complex;

[0062] Disperse 3 parts of the above-mentioned functional graphite oxide / heparin-quaternary ammonium salt anticoagulant compound and 0.5 part of the cross-linking agent peroxygen compound DCP in 100 parts of high-temperature vulcanized silicone rubber at 30 °...

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Abstract

Polymer / oxidized graphite nanoanticoagulant composite, with the components in below: polymer 100 units; oxidized graphite / disebrin quaternary composite 0.01-10 units; disperse medium 0-400 units; crosslinking agent 0-10 units; accelerating agent 0-0.1 units. The preparing process for the composite is: employing the disebrin quaternary composite as a new functional intercalary material to inserting into the slice layer of the layered oxidized graphite; to form functional anticoagulant intercalary material-oxidized graphite nano-intermediate, carrying out intercalary reaction with polymer to make the disperse phase be integrated into nanograde graphite slice and filled uniformly in the polymer, then getting the polymer / oxidized graphite- disebrin- quaternary nanoanticoagulant composite. The invention can be widely used for anticoagulant in vessels compatible with blood (such as medical banticoagulant conduit, blood dialysis membrane, assisted circulation device, external blood return circuit connector, blood filter, blood restorer, appliance for blood sampling and transfusion, and etc).

Description

technical field [0001] The invention provides a polymer / graphite oxide nano anticoagulant composite material and a preparation method thereof, and particularly relates to a functional intercalation agent containing a heparin-quaternary ammonium salt complex and the use of this functional intercalation agent to improve A polymer / graphite oxide-heparin-quaternary ammonium salt composite nano anticoagulant composite material formed by filling a polymer matrix with permanent graphite oxide and a preparation method thereof. Background technique [0002] Medical materials in contact with biological tissues should have good biocompatibility, including tissue compatibility, blood compatibility and mechanical compatibility. Histocompatibility means that the material will not cause cell mutation, distortion, cancer and rejection after contact with biological tissues and body fluids. Hemocompatibility means that the material does not cause denaturation of plasma proteins after contact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/10
Inventor 周宁琳黄颖霞沈健李利魏少华张峻
Owner NANJING NORMAL UNIVERSITY
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