The invention discloses a dicamba compound herbicide which comprises a first active ingredient-dicamba, a second active ingredient and an auxiliary. The second active ingredient is one of or a combination of several of chlortoluron, chlorsulfuron, isoproturon, methsulfuron, iodosulfuron methyl sodium salt, clodinafop acid and pinoxaden, the auxiliary is a composition of more than two of dispersant, emulsifier, wetting agent, disintegrant, binder, anti-freezing agent, thickener, filler and solvent, and the compound herbicide can be wettable powder, emulsifiable concentrate, suspension agent, water dispersible granules and soluble liquid. A mass ratio of the first active ingredient to the second active ingredient in the dicamba compound herbicide is 1:50-1:2. The dicamba compound herbicide can be used for preventing and killing both broad-leaf weed and grassy weed in wheat fields, can expand weed killing spectrum, improve prevention effect and delay weed resistance and can reduce consumption of dicamba, lower using cost and improve safety to wheat.