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38 results about "Methionine aminopeptidase" patented technology

Methionyl aminopeptidase (EC 3.4.11.18, methionine aminopeptidase, peptidase M, L-methionine aminopeptidase, MAP) is an enzyme. This enzyme catalyses the following chemical reaction. This membrane-bound enzymatic activity is present in both prokaryotes and eukaryotes.

Methionine aminopeptidase-2 inhibitors and methods of use thereof

InactiveUS20070161570A1Better pharmacokinetic profileLimit CNS side effectOrganic active ingredientsBiocideMedicineMethionine aminopeptidase
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of inducing an immunosupressed condition and / or treating chronic allograft vasculopathy in a subject undergoing or who has undergone a transplant, by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
Owner:PRAECIS PHARM INC

Preparation method for recombinant human interferon alpha-2b free of methionine

The invention specifically relates to a preparation method for recombinant human interferon alpha-2b free of methionine, which belongs to the field of preparation of interferon. According to the method, primers are designed to amplify gene segments of methionine aminopeptidase, the gene segments of methionine aminopeptidase are cloned into the expression plasmid of pACYCDuct-1 to obtain the recombinant expression plasmid of pACYCDuct-1-MetAP which is introduced into the recombinant expression plasmid of pJW2-rhIFN-alpha-2b containing human interferon alpha-2b genes, 0.1 mu M IPTG is utilized to induce methionine aminopeptidase to express, human interferon alpha-2b protein is induced to express at a temperature of 40 DEG C, and methionine at N terminal of the human interferon alpha-2b protein is resected in the process of expression. The preparation method provided in the invention enables unnecessary Met residue at the N terminal of human interferon alpha-2b to be removed, stability and antiviral activity of human interferon alpha-2b to be improved, immunogenicity of human interferon alpha-2b to be reduced and an incidence rate of adverse reactions during utilization of human interferon alpha-2b by patients to be reduced.
Owner:ANHUI ANKE BIOTECHNOLOGY (GRP) CO LTD

Kit for detecting mycoplasma genitalium

The invention discloses a kit for detecting mycoplasma genitalium. The invention provides two schemes; in a scheme I, the kit comprises two reagents, namely methionine aminopeptidase and leucocyte esterase, wherein an enzyme substrate for detecting the activity of the methionine aminopeptidase is a methionine derivative containing a chromogen, and an enzyme substrate for detecting the activity ofthe leucocyte esterase is an ester derivative containing the chromogen; in a scheme II, the kit comprises three reagents, i.e., the kit is also comprises a proline aminopeptidase reagent on the basisof the scheme I, and an enzyme substrate for detecting the activity of proline aminopeptidase is a proline derivative containing the chromogen. According to the kit disclosed by the invention, autosynthetic enzyme or enzyme generated by stimulating parasitic cells during a growth process of the Mg can be detected through a dry chemical enzyme method, the purpose of detecting the mycoplasma genitalium can be achieved, and the kit has the advantages of quickness, simpleness, accuracy and the like. By adopting the kit for detecting the mycoplasma genitalium, the sensitivity and the specificity are higher, properties of the kit are similar to properties of existing like detection reagents, and clinical test needs can be completely met.
Owner:AUTOBIO DIAGNOSTICS CO LTD
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