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Method for producing fine powder and the fine powder produced by the same

a technology of fine powder and fine powder, which is applied in the direction of grain treatment, biocide, pharmaceutical product form change, etc., can solve the problems of contaminating difficult to make into a pharmaceutical product in some cases, and affecting the quality of the raw material to be pulverized, etc., to achieve easy water-solvable materials, pulverize low melting point materials, and uniform pulverization

Active Publication Date: 2015-06-02
MORIROKU CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0040]Due to the cold brittleness of the substance existing at a very low temperature and due to the effect of preventing particles from aggregation by the dispersive medium that permeates to a nicety of particles, the present invention can pulverize materials to fine particles of submicron size or nano-size, which cannot be attained by the conventional methods.
[0041]According to the conventional pulverization method, amorphous transformation of bulk powder is found after the pulverization, however, according to the present method for pulverization, neither crystalline transformation of bulk powder nor crystalline descent is found before and after the pulverization. In other words, the method of the present invention can pulverize bulk powder with retaining the crystal form and crystalline of the bulk powder.
[0042]The method of the present invention can pulverize low melting point materials or easily water-solvable materials. The method of the present invention can also pulverize materials more uniformly as compared to the method for pulverizing at normal temperature. Furthermore, the liquefied inert gas such as liquid nitrogen sublimes at a normal temperature and dry powder can be obtained directly from the material subject to the pulverization process. As a result, the present invention can improve the resolvability of bulk powder of drugs and medicines and, especially, the present invention will contribute to the development of pharmaceutical preparations that improves physiological application for oral administration due to the improvement of resolvability of low-solubility bulk powder of drugs. Thereby, the present invention can drastically improve the resolvability of active constituents of medicines and also improve the resolvability and the rate of dissolution of industrial materials when the present invention is applied to industrial materials.
[0043]The method of the present invention can pulverize the material and additives into the particles of submicron size or nano size so that the solvability of the pulverized material and additives can be improved dramatically and simultaneously, a homogeneous mixture of the material and additives pulverized into submicron size or nano size can be obtained by a simple and easy operation.
[0044]The method of the present invention can manufacture fine powder at a lower price and without difficulty and by smaller number of processes. Although the materials that can be pulverized by the present invention is not limited, water-soluble materials that are difficult to be pulverized by the conventional wet medium pulverization method and pharmaceutical bulk powder that should not be contaminated by any impurities can effectively be pulverized and dispersed by the method of present invention. Recently, the number of low solubility substances to be used as raw materials of pharmaceutical products is expressly increasing. It is eagerly required to improve the dissolution behavior of those medicines of low solubility by means of pulverization. The method for producing fine powder according to the present invention is expected to facilitate controlling the degree of pulverization and consequently improve the solubility and the rate of dissolution of medicines of low solubility, because the method of the present invention can improve the degree of pulverization of medicines merely by extending the processing time for pulverization, without carrying out the conventional process for changing beads. In addition, the method for producing fine powder according to the present invention can improve the collection rate of fine powder without contaminating expensive raw materials of medicines. Since the method for producing fine powder according to the present invention uses liquefied inert gas as dispersive medium, the raw materials can be pulverized without mixing dispersing agent such as a polymeric dispersant and a surfactant into the dispersive medium. Therefore, the fine powder to be produced is not contaminated with the exotic components for improving dispersion.
[0045]Further characteristics of the present invention become apparent from the following description of preferred embodiments.

Problems solved by technology

The medicines of a low solubility is not absorbed effectively from digestive organs and is increased in dosage and also varied in absorption depending upon individual differences of patients, and thereby becomes difficult in making into a pharmaceutical product in some cases.
As a result, the beads strike against an inner wall of the vessel or a rotating shaft of the disks, and thereby abrade the inner wall of the vessel or the rotating shaft of the disks.
Therefore, the materials of the vessel and the rotating shaft might mix in the slurry and contaminate the raw material to be pulverized.
In addition, the beads collide with each other and are subject to wear.

Method used

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  • Method for producing fine powder and the fine powder produced by the same
  • Method for producing fine powder and the fine powder produced by the same
  • Method for producing fine powder and the fine powder produced by the same

Examples

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example 1

[0111]FIG. 2 shows electron micrographs (SEM) of the original bulk of phenytoin and the pulverized particles of phenytoin. Comparing FIG. 2(B) and FIG. 2(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. Since the majority of the particles of phenytoin, which were pulverized by the LN2 bead mill, have the dimension of 1 μm or below, as shown in FIG. 2(B), it is found that the objective of pulverizing the material into submicron size has been attained by the ultra low temperature medium grinding with the LN2 bead mill, although it could not be attained by the conventional dry method for pulverization.

[0112]FIG. 29 shows a dry method particle size distribution that represents the effects of the rotating speed of the rotating shaft 2 on the particle size of pulverized phenytoin, while FIG. 30 shows a wet method particle size distribution that repre...

example 2

[0116]FIG. 3 shows electron micrographs (SEM) of the original bulk of ibuprofen and the pulverized particles of ibuprofen. Comparing FIG. 3(B) with FIG. 3(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. It should be noted that the pulverization of low melting point material such as ibuprofen (76° C.) could be improved because the attack of heat generated at the time of pulverization could be modified immediately according to the present invention.

example 3

[0117]FIG. 4 shows electron micrographs (SEM) of the original bulk of salbutamol sulfate and the pulverized particles of salbutamol sulfate. Comparing FIG. 4(B) with FIG. 4(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. It is also found that the method of the present invention is effective for the pulverization of water-soluble medicines such as salbutamol sulfate.

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Abstract

Disclosed is a manufacturing method for a fine powder exhibiting improved solubility, little impurity contamination, and a high recovery rate. Material to be ground and a grinding medium are suspended and stirred in a liquefied inert gas dispersion medium such as dried ice, and the material to be ground is made into a sub-micron or nano-sized fine powder. A uniform fine powder can be obtained when the material to be ground is a mixture having two or more components. Impurity contamination can be reduced by using granular dry ice as the grinding medium.

Description

TECHNICAL FIELD[0001]The present invention relates to a method for producing fine powder of raw and processed materials that are used for the products in all sorts of technical fields, such as pharmaceutical products, cosmetics, paint, copiers, solar cells, secondary batteries and recording media. The present invention further relates to the fine powder produced by the present method. The present invention especially relates to a method for producing fine powder having significantly improved dissolvability and mixing uniformity.BACKGROUND ART[0002]The existing candidate compounds for medicines often have a low solubility. The medicines of a low solubility is not absorbed effectively from digestive organs and is increased in dosage and also varied in absorption depending upon individual differences of patients, and thereby becomes difficult in making into a pharmaceutical product in some cases. In addition, particular medicines have a very small percentage of active ingredients in th...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61J3/02B02C17/16B02C19/18C01B32/55
CPCB02C19/186B02C17/16
Inventor NIWA, TOSHIYUKISUGIMOTO, SHOHEIDANJO, KAZUMINISHIO, MASAAKINAKANISHI, YASUOKAWAMURA, SAKIKO
Owner MORIROKU CHEM
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