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Method for producing fine powder and the fine powder produced by the same

a technology of fine powder and fine powder, which is applied in the direction of grain treatment, biocide, pharmaceutical product form change, etc., can solve the problems of contaminating difficult to make into a pharmaceutical product in some cases, and affecting the quality of the raw material to be pulverized, etc., to achieve easy water-solvable materials, pulverize low melting point materials, and uniform pulverization

Active Publication Date: 2015-06-02
MORIROKU CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for pulverizing materials to fine particles of submicron size or nano-size that cannot be attained by conventional methods. The method can pulverize low melting point materials, easily water-solvable materials, and materials that are difficult to be pulverized by conventional methods. The method can improve the dissolution and solubility of the pulverized materials, resulting in improved physiological application of drugs and industrial materials. The method is simple and easy to operate, and can manufacture fine powder at a lower price without difficulty. The method can also improve the degree of pulverization, collection rate of fine powder, and dissolution behavior of medicines of low solubility. The method can produce fine powder without contaminating expensive raw materials of medicines and is expected to facilitate controlling the degree of pulverization and improve the solubility and rate of dissolution of medicines of low solubility. The method uses liquefied inert gas as dispersive medium, which allows for the pulverization of materials without mixing dispersing agents such as polymeric dispersants and surfactants into the dispersive medium, resulting in fine powder that is not contaminated with exotic components for improving dispersion.

Problems solved by technology

The medicines of a low solubility is not absorbed effectively from digestive organs and is increased in dosage and also varied in absorption depending upon individual differences of patients, and thereby becomes difficult in making into a pharmaceutical product in some cases.
As a result, the beads strike against an inner wall of the vessel or a rotating shaft of the disks, and thereby abrade the inner wall of the vessel or the rotating shaft of the disks.
Therefore, the materials of the vessel and the rotating shaft might mix in the slurry and contaminate the raw material to be pulverized.
In addition, the beads collide with each other and are subject to wear.

Method used

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  • Method for producing fine powder and the fine powder produced by the same
  • Method for producing fine powder and the fine powder produced by the same
  • Method for producing fine powder and the fine powder produced by the same

Examples

Experimental program
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example 1

[0111]FIG. 2 shows electron micrographs (SEM) of the original bulk of phenytoin and the pulverized particles of phenytoin. Comparing FIG. 2(B) and FIG. 2(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. Since the majority of the particles of phenytoin, which were pulverized by the LN2 bead mill, have the dimension of 1 μm or below, as shown in FIG. 2(B), it is found that the objective of pulverizing the material into submicron size has been attained by the ultra low temperature medium grinding with the LN2 bead mill, although it could not be attained by the conventional dry method for pulverization.

[0112]FIG. 29 shows a dry method particle size distribution that represents the effects of the rotating speed of the rotating shaft 2 on the particle size of pulverized phenytoin, while FIG. 30 shows a wet method particle size distribution that repre...

example 2

[0116]FIG. 3 shows electron micrographs (SEM) of the original bulk of ibuprofen and the pulverized particles of ibuprofen. Comparing FIG. 3(B) with FIG. 3(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. It should be noted that the pulverization of low melting point material such as ibuprofen (76° C.) could be improved because the attack of heat generated at the time of pulverization could be modified immediately according to the present invention.

example 3

[0117]FIG. 4 shows electron micrographs (SEM) of the original bulk of salbutamol sulfate and the pulverized particles of salbutamol sulfate. Comparing FIG. 4(B) with FIG. 4(C), it was found that the particles pulverized by the LN2 bead mill were regular in shape and they are smaller in particle size and elongation than the particles pulverized by the Jet mill. It is also found that the method of the present invention is effective for the pulverization of water-soluble medicines such as salbutamol sulfate.

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Abstract

Disclosed is a manufacturing method for a fine powder exhibiting improved solubility, little impurity contamination, and a high recovery rate. Material to be ground and a grinding medium are suspended and stirred in a liquefied inert gas dispersion medium such as dried ice, and the material to be ground is made into a sub-micron or nano-sized fine powder. A uniform fine powder can be obtained when the material to be ground is a mixture having two or more components. Impurity contamination can be reduced by using granular dry ice as the grinding medium.

Description

TECHNICAL FIELD[0001]The present invention relates to a method for producing fine powder of raw and processed materials that are used for the products in all sorts of technical fields, such as pharmaceutical products, cosmetics, paint, copiers, solar cells, secondary batteries and recording media. The present invention further relates to the fine powder produced by the present method. The present invention especially relates to a method for producing fine powder having significantly improved dissolvability and mixing uniformity.BACKGROUND ART[0002]The existing candidate compounds for medicines often have a low solubility. The medicines of a low solubility is not absorbed effectively from digestive organs and is increased in dosage and also varied in absorption depending upon individual differences of patients, and thereby becomes difficult in making into a pharmaceutical product in some cases. In addition, particular medicines have a very small percentage of active ingredients in th...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61J3/02B02C17/16B02C19/18C01B32/55
CPCB02C19/186B02C17/16
Inventor NIWA, TOSHIYUKISUGIMOTO, SHOHEIDANJO, KAZUMINISHIO, MASAAKINAKANISHI, YASUOKAWAMURA, SAKIKO
Owner MORIROKU CHEM
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