Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anticancer composition containing mixed herbal medicine extract as active ingredient

Inactive Publication Date: 2016-08-25
UNIV IND COOP GRP OF KYUNG HEE UNIV
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The mixed extract of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii has the ability to stop the growth of cancer cells and inhibit the spread of cancer to other parts of the body. This makes it useful for preventing and treating cancer, as well as supporting other cancer treatments.

Problems solved by technology

A carcinogen which is the cancer initiator includes smoking, ultraviolet rays, chemicals, foods and other environmental factors, but the initiator is various and thus, it is difficult to develop medicines and effects of the medicines vary according to a generated site.
Currently, since materials used as the medicines have significant toxicity and do not selectively remove only the cancer cells, it is urgently required to develop effective anticancer agents having low toxicity for treating the cancer after causing the cancer and preventing the cancer.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anticancer composition containing mixed herbal medicine extract as active ingredient
  • Anticancer composition containing mixed herbal medicine extract as active ingredient
  • Anticancer composition containing mixed herbal medicine extract as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Mixed Extract of Astragalus membranaceus, Angelica Gigas, and Trichosanthes kirilowii

[0068]Astragalus membranaceus (Am), Angelica gigas (Ag), and Trichosanthes kirilowii Maximowicz (Tk) were mixed with a weight ratio (w / w) of (1) 1:1:1 or (2) 3:1:1, respectively, put in an extractor, and extracted for 2 to 3 hours after adding 8 to 10 times water and 30% (v / v) ethanol or 80% ethanol, respectively. The extract was filtered and the filtrate was dried after decompression-concentrating to obtain a mixed extract (a water extract, a 30% ethanol extract, and a 80% ethanol extract) of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii (about 35.5% average yield of the mixed extract mixed with a weight ratio of 1:1:1 and about 29.85% average yield of the mixed extract mixed with a weight ratio of 3:1:1).

example 2

Preparation of Mixed Extract of Astragalus membranaceus, Angelica Gigas, Trichosanthes Kirilowii, and Ginseng

[0069]Astragalus membranaceus, Angelica gigas, Trichosanthes kirilowii Maximowicz, and ginseng were mixed with a weight ratio (w / w) of (1) 1:1:1:1 or (2) 3:1:1:1, respectively, put in an extractor, and extracted for 2 to 3 hours after adding 8 to 10 times water and 30% (v / v) ethanol or 80% ethanol, respectively. The extract was filtered and the filtrate was dried after decompression-concentrating to obtain a mixed extract (a water extract, a 30% ethanol extract, and a 80% ethanol extract) of Astragalus membranaceus, Angelica gigas, Trichosanthes kirilowii, and ginseng (about 28% average yield of the mixed extract mixed with a weight ratio of 1:1:1:1 and about 24.24% average yield of the mixed extract mixed with a weight ratio of 3:1:1:1).

experimental example 1

Verification of Effect of Mixed Extract of the Present Invention on Growth of Cancer Cells According to Extractant

[0070]In order to verify an effect of the mixed extracts prepared in Examples 1 and 2 on a growth of cancer cells according to an extractant, an MTT assay was performed by a known method in the related art. A cancer cell line used an MDA-MB-231 breast cancer cell line.

[0071]In more detail, in the MDA-MB-231 breast cancer cell line cultured on a 96-well plate, the mixed extract of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii or the mixed extract of Astragalus membranaceus, Angelica gigas, Trichosanthes kirilowii, and ginseng which was prepared in Examples 1 and 2 was treated with various concentrations (50 to 500 μg / ml) and then cultured for 48 hours under a condition of 37° C. and 5% CO2. Thereafter, a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent was treated in each cell, the cells were further cultured for 4 hours, a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An embodiments of the invention relates to a composition containing, as an active ingredient, a mixed extract of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, for preventing or treating cancer. The mixed extract of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii according to this embodiment of the invention does not impact normal cell growth, while having an anticancer effect which specifically inhibits the proliferation of cancer cells, and an excellent effect of inhibiting metastasis of cancer cells, and thus can be useful in preventing or treating cancer and supplementing cancer treatment.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition including, as an active ingredient, a mixed extract of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, for preventing or treating cancer.BACKGROUND ART[0002]Cancer is one of incurable diseases to be resolved by humanity and the huge capital has been invested in development for treating the cancer around the world. In Korea, the cancer is a first disease among causes of disease death, and more than 100,000 persons per year are diagnosed as the cancer and about more than 60,000 persons have died. A carcinogen which is the cancer initiator includes smoking, ultraviolet rays, chemicals, foods and other environmental factors, but the initiator is various and thus, it is difficult to develop medicines and effects of the medicines vary according to a generated site. Currently, since materials used as the medicines have significant toxicity and do not selectively remove only the cancer cells, it is urg...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/481A61K36/428A61K36/258A61K36/232
CPCA61K36/428A61K36/232A61K36/258A23L1/3002A23V2002/00A61K36/481A23L33/105A61P35/00A61P35/02A61K2300/00A23V2200/308A23V2250/21
Inventor KO, SEONG GYUCHO, SUNG GOOKCHOI, YOUN KYOUNGYIM, HEE SUN
Owner UNIV IND COOP GRP OF KYUNG HEE UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com