Anti-Scalping Transdermal Patch Packaging Film

Abstract

A flexible, multilayer packaging film suitable for packaging an article for collecting or administering a physiologically active substance such as transdermal drug delivery patches, oral dissolvable thin strips, and disposable, microfluidic test cassettes having:(a) an article contact layer having at least 90 wt. % of a norbornene ethylene copolymer or derivative thereof and a glass transition temperature of from 65 to 110° C.;(b) a polyolefin bulk layer;(c) a first intermediate adhesive layer;(d) an oxygen barrier layer having an oxygen transmission rate of less than less than 0.01 cm3 / 100 inches2 / 24 hours at 1 atmosphere and 23° C.;(e) a second intermediate adhesive layer; and(f) an exterior protective layer comprising a polymer selected from the group consisting of amorphous polyester, polyamide, polyolefin, nylon, polypropylene, or copolymers, blends or derivatives thereof;wherein said multilayer film has the following properties:a WVTR of less than 0.01 g / 100 inches2 per 24 hours at Room Temperature (RT) (23° C.) and 1 atmosphere; and a thickness of 10 mil or less.

Description

BACKGROUND[0001]1. Technical Field[0002]The present application relates generally to packaging suitable for packaging an article for collecting or administering a physiologically active substance such as transdermal drug delivery patches.[0003]2. Background Information[0004]Pharmaceuticals such as the drugs fentanyl and nicotine are often administered through the use of transdermal patches which are applied to a patient's skin to permit drug delivery over time by absorption. Prior to application of a drug containing patch, the patch is packaged in a pouch which is designed to be opened to permit access to the patch by the patient or caregiver for application to a patient's skin. Suitable packaging for transdermal patches should contain the patch and its drug within the package while protecting the patch from contamination and deleterious effects from the external environment. Thus, articles such as a pouch may hold a transdermal patch to protect the patch and its drug contents from ...

AI Technical Summary

Benefits of technology

The patent describes a flexible packaging film that is suitable for the packaging of various articles like transdermal drug delivery patches, oral dissolvable thin strips, and disposable microfluidic test cassettes. The film has several layers including an article contact layer, a polyolefin bulk layer, an adhesive layer, an oxygen barrier layer, and an exterior protective layer. The film has good properties like a low water vapor transmission rate and is thin and flexible. Its thickness is 10 mil or less.

Problems solved by technology

While Barex® has superb anti-scalping properties it is very expensive, poor tear properties that make pouch opening difficult, and has limited availability which creates supply chain risk because of its manufacture on only a single production reactor.

Polyester suffers from the disadvantage of being less resistant to scalping of certain chemicals than desired and its tear properties are also less than desired.

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