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Growth control of oral and superficial microorganisms using gallium compounds

a gallium compound and microorganism technology, applied in the field of growth control of oral and superficial microorganisms using gallium compounds, can solve the problems of gallium entering microorganisms, interfering with the metabolism of organisms, and dna and protein synthesis

Inactive Publication Date: 2011-02-17
MT SINAI SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]This invention is based upon the inventors' use of gallium compounds to control the growth of pathogenic microorganisms at specific sites, such as oral cavities, nasal cavities, eyes, skins and vagina, in host organisms of such p

Problems solved by technology

It is speculated that gallium enters microorganisms via their iron transport mechanisms and interferes with their DNA and protein synthesis.
Parenterally or orally administered gallium compounds are easily taken up by the macrophages through transferrin receptors and then, within the cells, are taken up by the infecting organisms, thereby interfering with the organisms' metabolism.

Method used

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  • Growth control of oral and superficial microorganisms using gallium compounds
  • Growth control of oral and superficial microorganisms using gallium compounds

Examples

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Effect test

example 1

Toothpaste Formulation

[0068]A toothpaste is formulated to contain gallium nitrate at 50 μM and 0.2% by weight sodium fluoride as active ingredients in the treatment and prevention of dental and periodontal disease. The formulation also contains conventional inactive ingredients including water, sorbitol, glycerin, hydrated silica, polyethyleneglycol, xanthan gum, sodium saccharin, methylparaben, and propylparaben. These are blended in amounts known to those skilled in the art to obtain a toothpaste of appropriate consistency. The formulation can be packaged in conventional toothpaste tubes, and used in the normal manner.

example 2

Treatment of Vaginal Yeast Infection

[0069]The present invention is applied to the formulation of suppositories and creams for the treatment of internal and external vaginal yeast infections, respectively, as follows. Gallium citrate at 200 μM is combined with inactive ingredients including, in the case of a suppositories, gelatin, glycerin, lecithin, mineral oil, titanium oxide, and white petrolatum, or, in the case of external creams, benzoic acid, isopropylmyristate, polysorbate 60, potassium hydroxide, propyleneglycol, distilled water and stearyl alcohol. These formulations can be suitably packaged for use in a conventional manner.

example 3

Disinfection of Inanimate Objects

[0070]A liquid formulation in a form of an aqueous solution of 5% by weight gallium phosphate and 5% by weight dimethyl benzyl ammonium chloride is prepared and packaged for use in households, hospitals, barber shops and beauty parlors as a surface treatment agent for disinfecting objects whose surfaces are prone to acting as sites for the growth of pathogenic organisms. Such a formulation can be used by application to such surfaces in a conventional manner.

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Abstract

The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a gallium compound to an affected area. In particular, the present invention provides methods for treating or preventing dental caries, vaginal infections, skin infections, and so forth. Gallium compounds can be formulated as toothpaste, mouthwash, cream, ointment, gel, solution, eye drops, suppository, and the like. Furthermore, the invention provides methods for controlling microbial growth on environmental surfaces, including those of toothbrush, denture, dental retainer, contact lens, catheter, food stuff, and so forth. In addition, the present invention provides animal feeds which contain gallium compounds that promote the animal growth and prevent the animals from infections as well as protect consumers from post processing infections.

Description

[0001]The present application claims the benefits of U.S. provisional application Ser. No. 60 / 731,875, filed Nov. 1, 2005, which is incorporated herein by reference in its entirety.1. INTRODUCTION[0002]The present invention relates to methods of controlling growth of microorganisms, in particular, oral and superficial bacteria and fungi that cause disorders or diseases in host organisms, by applying gallium compounds to an affected or intended area topically or superficially. The invention further relates to formulations comprising gallium compounds for controlling growth of such microorganisms and objects or materials coated therewith or incorporating same. In addition, the invention relates to animal feeds containing gallium compounds.2. BACKGROUND OF THE INVENTION[0003]Gallium is a group IIIa semi-metallic element that has been used for many years for diagnosing neoplasms and inflammation in the field of nuclear medicine. Gallium has also shown some efficacy in the treatment of c...

Claims

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Application Information

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IPC IPC(8): A61K8/18C07F5/00C07K14/79A61K31/28A61K33/42A61K33/24A61K31/555A61K35/74A01N59/16A61Q11/00A61P1/14A61P31/00C01G15/00C01B25/37C22C28/00
CPCA23K1/175A01N55/02A23L3/358A23V2002/00A61K8/19A61K8/24A61K2800/58A61L2300/102A61L2300/404A61Q11/02A23L1/304A61Q11/00A61L15/46A61L12/088A61L2/18A61L2/16A01N59/16A61K8/365A23V2200/312A23V2200/3204A23V2250/1596A23V2200/10A61K9/0063A61K9/06A61K31/28A61K31/555A61K33/24A61L15/44A61L2300/224A23K20/20A23L33/16A61P1/02A61P1/14A61P15/00A61P15/02A61P17/00A61P27/02A61P31/00A61P31/04A61P31/10Y02A50/30
Inventor PERL, DANIEL P.MOALEM, SHARON
Owner MT SINAI SCHOOL OF MEDICINE
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