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Hemostatic Composition with Magnetite

Inactive Publication Date: 2010-09-09
BIOLIFE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018]Magnetite addition to a potassium ferrate / strong acid cation exchange resin powderous mixture provides greatly improved delivery and control of the application of the hemostasis powder onto the wound site. Adding Magnetite to a potassium ferrate / strong acid cation exchange resin mixture at room temperature did not decrease the strength of a blood seal. Correspondingly, adding Hematite reduced the strength of the blood seal.Mechanism of Action
[0025]When powder mixtures are used for hemostasis, the bleeding surface is often not flat. Bone-dry powders tend to fall off the site at which they are aimed. Previously disclosed powder containment devices (PCD) are used to reduce the spillage. They are not, however, completely reliable, particularly for stopping bleeding around catheter lines on vertical or near vertical surfaces as the powder pile can spill over the edge of the PCD. Mixing Magnetite with the powder will allow it to be applied, transported, or held in place with a magnet. The incorporation of Magnetite to the hemostatic powder allows dramatic improvements in the delivery and control during application on a wound site.

Problems solved by technology

Correspondingly, adding Hematite reduced the strength of the blood seal.

Method used

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  • Hemostatic Composition with Magnetite
  • Hemostatic Composition with Magnetite
  • Hemostatic Composition with Magnetite

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029]A level study of Povidone Iodine (PI) in 1:7 powder was tested with Aspergillus niger in a 7-day, daily re-challenge standardized test. A >4 log kill was achieved when the PI≧2%. Adding small amounts of PI to 1:7 powder had no effect on hemostasis but did provide the kill necessary to claim that the device created a 7-day antimicrobial barrier. This is a commercial breakthrough in that hospitals want and are now provided, an all-in-one product wherein hemostasis is achieved, exudate is absorbed, 24-48 hour dressing changes are eliminated and there is a reduction in hospital-acquired infections.

Dynamic Pneumatic Hemostasis Test Apparatus

[0030]Referring to FIG. 8, the preferred apparatus for testing each test sample includes the use of air pressure to dislodge an aluminum disk adhered to a test block. Blood and powder are used to create the adhesive. The test measures the cohesive strength of the seal around the edges of the aluminum disk. A needle valve and an air regulator are...

example 2

[0040]Mixtures of Magnetite (Mag), a ferrate powder commercially available as QR Powder (QR) from assignee herein, Povidone Powder (PI), dry Hydrogen Resin and Hematite were tested in the above-described dynamic pneumatic hemostasis apparatus to compare the cohesive nature of each of the mixtures. Air pressure through a ⅛″ hole was used to lift a small thin aluminum disk from a testing block. Over the aluminum disk was ˜0.5 ml of whole EDTA treated bovine blood, and ˜1 g of one of the powder mixtures. In one set of tests, a 200 gm weight was left in place over the powder, and in the other test set, the weight was removed before the system was pressurized. The system was capable of creating +500 mm Hg of pressure thru the ⅛″ hole. The measurement of cohesion for each mixture was taken at the point when the air pressure caused the disk to lift and release the pressure held beneath. The results are summarized in Table 1.

TABLE 1Cohesive Strengths (mm Hg) of Mixtures of MaterialsAveragem...

example 3

[0042]In another series of experiments, the level of Magnetite added to QR, (a 1:7 mixture of ferrate / hydrogen resin) was varied from 0% to 100% and the weight in grams of mixture lifted by a standard magnet measured. As demonstrated, more Magnetite results in more total mass being held by the magnet. The strength of the magnet affects the amount of powder that can be held. There is a minimum amount of Magnetite needed for each device depending on the type of magnet used and the amount of powder needed to be applied.

QR powder was mixed with varying amounts of Magnetite and different types of magnets were used to determine the mass of powder that could be held.

TABLE 2Mass Pick Up (gms) by Addition of Magnetite%%QRMagFrig-MagBk CerCl-F-SuF-SuSm NeoLg Neo10000.00730.00210.00230.00170.003198.51.50.37180.26990.30380.33989730.49950.3980.51280.761690100.17581.39760.06490.70711.4592.420970302.72052.04183.350930700.43583.54080.36831.46652.59245.0837010010.1903

Three of the sets of data from T...

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Abstract

A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]Not applicableSTATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not applicableINCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC[0003]Not applicableBACKGROUND OF THE INVENTION[0004]1. Field of the Invention[0005]This disclosure relates to improved delivery and control of hemostasis powder in vascular access procedures and in other hemostasis control procedures and more particularly to such compositions with Magnetite for enhanced control of the powdery composition.[0006]2. Description of Related Art[0007]Hemostasis powders are well known. Thompson et al, U.S. Pat. Nos., 4,545,974 & 4,551,326, disclose processes for the manufacture of potassium ferrate and similar high oxidation state oxyiron compounds. Patterson et al U.S. Pat. No., 6,187,347 and Patterson et al U.S. Pat. No., 6,521,265, disclose the mixing of potassium ferrate and anhydrous strongly acidic cation exchange resins for the cessation of ble...

Claims

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Application Information

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IPC IPC(8): A61K31/74A61K33/26A61P17/02
CPCA61K9/0009A61K9/0014A61K31/74A61K33/26A61L15/42A61N2/002A61L2400/04A61K2300/00A61P17/02
Inventor HEN, JOHNKEENE, TALMADGE KELLYTRAVI, MARK
Owner BIOLIFE
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