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Medicine, Food and Drink or Feed Containing Sphingomyelin

Inactive Publication Date: 2010-02-25
SNOW BRAND MILK PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]According to the present invention, sphingomyelin can be used as 1) a sialomucin secretion promoter, 2) an agent for preventing drunken sickness (hangover), 3) an antiallergic agent, 4) an antioxidant, 5) an agent for defending against infection, 6) a hair growth agent, 7) a therapeutic agent for demyelinating disease, 8) an anti-pigmentation agent, 9) an anti-inflammatory agent, or 10) an agent for improving learning ability.

Problems solved by technology

However, its other effects have been little known.

Method used

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  • Medicine, Food and Drink or Feed Containing Sphingomyelin

Examples

Experimental program
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Effect test

example 1

[0021]A reaction solution obtained by allowing protease to act on a 10% aqueous solution of a whey protein concentrate (WPC) was subjected to extraction with a chloroform-methanol (2:1) solution, and the extract was then concentrated and further subjected to acetone extraction to obtain a complex lipid fraction. Next, this complex lipid fraction was subjected to stepwise extraction with a chloroform-methanol solution using Florisil column chromatography to obtain a phospholipid fraction. This phospholipid fraction was subjected to stepwise extraction with a chloroform-methanol solution using silica gel chromatography to obtain a fraction, which was then freeze-dried to obtain a sphingomyelin raw material. This sphingomyelin raw material was treated by thin-layer chromatography, followed by color development with a Dittmer reagent. A sphingomyelin content measured by a densitometry method was 95.2%. This sphingomyelin raw material can be used directly as an agent of the present inven...

example 2

[0082]Raw materials were mixed according to formulation shown in Table 18 and then compressed into 1 g by a standard method to produce the pharmaceutical agent of the present invention in a tablet form.

TABLE 18Hydrous crystalline glucose83.5(% by weight)Sphingomyelin raw material10.0(sphingomyelin content: 10%,Phospholipid 500,manufactured by Fonterra)Mineral mixture5.0Sugar ester1.0Flavor0.5In this context, this pharmaceutical agent (1 g) contained 10 mg of sphingomyelin.

example 3

[0083]50 g of a sphingomyelin raw material having a sphingomyelin content of 25% (Phospholipid 700, manufactured by Fonterra) was dissolved as the agent of the present invention in 4950 g of deionized water, and the solution was heated to 50° C. and then mixed by stirring at 6000 rpm for 30 minutes using a TK homomixer (TK ROBO MICS; manufactured by Tokushu Kika Kogyo Co., Ltd.) to obtain a sphingomyelin solution having a sphingomyelin content of 250 mg / 100 g. Into 4.0 kg of this sphingomyelin solution, 5.0 kg of casein, 5.0 kg of soybean proteins, 1.0 kg of fish oil, 3.0 kg of perilla oil, 18.0 kg of dextrin, 6.0 kg of a mineral mixture, 1.95 kg of a vitamin mixture, 2.0 kg of an emulsifier, 4.0 kg of a stabilizer, and 0.05 kg of a flavor were formulated, and this formulation was packaged into a 200-ml retort pouch and sterilized at 121° C. for 20 minutes using a retort sterilizer (primary pressure vessel, TYPE: RCS-4CRTGN, manufactured by Hisaka Works, Ltd.) to produce 50 kg of a ...

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Abstract

It is intended to find novel pharmaceutical use of sphingomyelin and to provide preventive or therapeutic agents for various diseases as well as a food and drink product and feed comprising any of these agents. The present invention provides a pharmaceutical agent which contains sphingomyelin as an active ingredient and is any of the following agents: 1) a sialomucin secretion promoter, 2) an agent for preventing drunken sickness (hangover), 3) an antiallergic agent, 4) an antioxidant, 5) an agent for defending against infection, 6) a hair growth agent, 7) a therapeutic agent for demyelinating disease, 8) an anti-pigmentation agent, 9) an anti-inflammatory agent, and 10) an agent for improving learning ability. The present invention also provides a food and drink product or feed, characterized by comprising the agent. It is preferred that the sphingomyelin should be derived from milk.

Description

TECHNICAL FIELD[0001]The present invention relates to a pharmaceutical agent which contains sphingomyelin and has novel use. More specifically, the present invention relates to a pharmaceutical agent which contains sphingomyelin and is a sialomucin secretion promoter, an agent for preventing drunken sickness (hangover), an antiallergic agent, an antioxidant, an agent for defending against infection, a hair growth agent, a therapeutic agent for demyelinating disease, an anti-pigmentation agent, an anti-inflammatory agent, or an agent for improving learning ability, and to a food and drink product or feed comprising any of these agents.BACKGROUND ART[0002]Sphingomyelin is a type of phospholipid found abundantly in milk and accounts for approximately 30% of phospholipids in cow milk. Sphingomyelin has a structure in which phosphocholine is bound with a ceramide skeleton composed of sphingosine and fatty acid, and has been known to be also found in the brain or nervous tissues. Moreover...

Claims

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Application Information

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IPC IPC(8): C07F9/09
CPCA23K1/164A23L1/3008A23K1/1866A23L1/30A23L2/52A23V2002/00A61K8/68A61K31/688A61Q7/00A61Q19/02A23K1/1846A23V2250/21A23V2200/304A23V2200/32A23K20/158A23K50/40A23K50/48A23L33/10A23L33/12C07F9/10A61P1/00A61P17/00A61P17/14A61P21/00A61P25/00A61P25/28A61P29/00A61P31/00A61P37/08A61P39/06A61K35/20
Inventor KATO, KENMIURA, SUSUMUTANAKA, LEOUENO, HIROSHIUEDA, NORIKOHARUTA, YUKOYOSHIOKA, TOSHIMITSU
Owner SNOW BRAND MILK PROD CO LTD
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