Computer-assisted means for assessing lifestyle risk factors

Abstract

The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan.

Description

[0001] This application is a divisional of Ser. No. 09 / 771,933, filed Jan. 30, 2001 (allowed), the entire contents of which is incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates to methods of assessing disease susceptibility. In particular, it relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. BACKGROUND TO THE INVENTION [0003] Cancer is a disease influenced primarily by external factors. Up to 80% of human cancers arise from exposure to environmental agents. The majority of cancer is believed to be preventable because exposure to these external factors should be manageable (Giovannucci, 1999; Perera, 2000). [0004] Human tumours result from a series of mutational events, leading to the loss of the regulatory mechanisms that govern normal cell behaviour and ultimately resulting in the formation of a tumour with full metastatic (or invasive) potential (Smith, 1995). All higher organisms h...

AI Technical Summary

Benefits of technology

This approach allows for individualized advice that addresses specific genetic profiles, reducing disease risk by providing personalized dietary and lifestyle recommendations tailored to an individual's unique genetic make-up and susceptibility factors.

Problems solved by technology

Human tumours result from a series of mutational events, leading to the loss of the regulatory mechanisms that govern normal cell behaviour and ultimately resulting in the formation of a tumour with full metastatic (or invasive) potential (Smith, 1995).

Unfortunately, the metabolic pathways do not always lead to detoxification of the toxin.

Variable levels of expression of these enzymes could result in increased or decreased carcinogen activation.

However, defining the precise roles of specific dietary factors in the development of cancer is difficult due to the multitude of variables involved (Perera, 2000).

Further complications arise due to differences in methodology, control populations, types of carcinogens, and amounts of exposure to carcinogens.

Low intake can lead to micronutrient deficiency, which has been shown to cause DNA damage in a way that mimics radiation damage by causing single and double-stranded breaks, oxidative lesions or both.

Thus, diet can be a direct supply of genotoxic compounds or may cause chronic irritation or inflammation (Giovannucci, 1999).

Such advice can therefore only be very general and cannot, by its very nature, take account of the particular genotype of an individual.

Moreover, in recent years, there has been much media publicity of research findings on links between particular foods, drugs etc and medical conditions, often causing health scares.

As the factors that contribute to disease susceptibility, for example cancer, or cardiovascular disease susceptibility vary between populations and between individuals of populations, it is often impossible for an individuals to derive useful advice appropriate to his or her particular circumstances from such reports.

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