Compositions including modafinil for treatment of eating disorders and for appetite stimulation

a technology of eating disorders and compositions, applied in the field of neuropharmacological agents, can solve the problems of difficulty in administering oral peptides active in the brain and central nervous system, and achieve the effects of stimulating appetite, stimulating appetite, and increasing the rate of weight gain

Inactive Publication Date: 2002-09-12
SCAMMELL THOMAS E +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016] an amount of a modafinil compound such that one or more unit doses thereof are effective to stabilize or improve the symptoms of an eating disorder in said subject upon periodic administration.
[0018] an amount of a modafinil compound such that one or more unit doses thereof are effective to increase the appetite of an animal upon periodic administration.
[0020] (1) one or more unit doses, each such unit dose containing an amount of a modafinil compound such that said one or more unit doses thereof are effective to stabilize or improve a symptom of an eating disorder in said mammal upon periodic administration and the unit doses being administered periodically, and

Problems solved by technology

Although the appetite stimulating neuropeptides may prove useful for stimulating appetite, and / or promoting weight gain in a variety of situations, such as eating disorders including anorexia nervosa, disease related weight loss, or even in agricultural applications such as promoting faster weight gain in weanling animals, it is difficult to administer peptides that are active in the brain and central nervous system by an oral route.

Method used

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  • Compositions including modafinil for treatment of eating disorders and for appetite stimulation

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Experimental program
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Embodiment Construction

[0029] Modafinil is an agent with activity in the central nervous system, and has been developed as a treatment for excessive daytime sleepiness associated with narcolepsy. The primary pharmacological activity of modafinil, like amphetamine-like agents, is to promote wakefulness. Modafinil promotes wakefulness in rats (Touret, et al., Neuroscience Letters, 189:43-46 (1995); Edgar and Seidel, J. Pharmacol. Exp. Ther., 283:757-69 (1997)), cats (Lin et al., Brain Research, 591:319-326 (1992)), canines (Shelton et al., Sleep 18(10):817-826, (1995)) and non-human primates (DS-93-023, pp 180-181; Hemant et al., Psychophannacology, 103:28-32 (1991)), as well as in models mimicking clinical situations, such as sleep apnea (English bulldog sleep disordered breathing model) (Panckeri et al, 1996) and narcolepsy (narcoleptic canine) (Shelton et al., Sleep 18(10):817-826, (1995)). Modafinil has also been demonstrated to be a useful agent in the treatment of Parkinson's disease (U.S. Pat. No. 5,...

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Abstract

Modafinil is effective in improving symptoms of eating disorders or in stimulating appetite.

Description

BACKGROUND OF THE INVENTION[0001] 1. Field of the Invention[0002] The present invention is related to the fields of neuropharmacological agents, including agents that are useful in the treatment of eating disorders and agents that stimulate appetite to produce weight gain in both human and animals in need thereof.[0003] 2. Description of Related Art[0004] Modafinil (C.sub.15H.sub.15NO.sub.2S), 2-(benzhydrylsulfinyl) acetamide, or 2-[(diphenylmethyl) sulfinyl] acetamide, is a synthetic acetamide derivative with wake-promoting activity, the structure of which has been described in French Pat. No. 78 05 510 and in U.S. Pat. No. 4,177,290. Modafinil was tested in combination with various agents including apomorphine, amphetamine, reserpine, oxotremorine, hypnotics, yohimbine, 5-hydroxytryptophan, monoamine oxidase inhibitor (I.M.A.O.), and in several behavioral conditions, as described in the cited patents. The conclusion from such tests is that modafinil presents a neuropsychopharmacol...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/20A61K31/16A61K31/165A61K47/02A61K47/12A61K47/26A61K47/32A61K47/36A61P1/14
CPCA61K31/165A61P1/14A61P3/04
Inventor SCAMMELL, THOMAS E.MILLER, MATTHEW S.
Owner SCAMMELL THOMAS E
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