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Process for preparing emodic acid

A technology of rhein and rhubarb, which is applied in the field of compound preparation, can solve the problem of low yield, and achieve the effects of low production equipment requirements, simple processing, and easy-to-obtain raw materials

Inactive Publication Date: 2007-05-30
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the total synthesis goes through nearly 9 steps of reaction to finally synthesize rhein, and the yield is not high

Method used

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  • Process for preparing emodic acid
  • Process for preparing emodic acid
  • Process for preparing emodic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Specifications of medicinal materials: medicinal rhubarb; all reagents used are chemically pure.

[0025] The root of the raw material rhubarb is crushed, and the powder is extracted with dilute sulfuric acid and dichloromethane. After pouring out the acid solution, continue to extract twice with dichloromethane. The dichloromethane layers were combined and concentrated. Extract three times with sodium bicarbonate to separate the upper layer of lye and combine to neutralize to obtain rhein monomer. The dichloromethane layer was further extracted three times with sodium hydroxide. The dichloromethane layer was collected and concentrated, then extracted with sodium hydroxide until it was colorless, and the combined lye was neutralized with acid to obtain a mixed precipitate of yellow chrysophanol and physcion methyl ether.

[0026] After the precipitate is dried, weigh and dissolve it in glacial acetic acid and stir, then add hydrobromic acid and stir to raise the temp...

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Abstract

The invention discloses a making method of rhein, which is characterized by the following: extracting rhein from plant rhubarb horsetails; adopting residual drug slag as raw material; saving cost; protecting environment without constructing mother ring; reducing reciprocal operation in other synthetic routes; simplifying disposing course; improving total receiving rate at 56%.

Description

technical field [0001] The invention relates to a preparation method of a compound, in particular to a preparation method of rhein. Background technique [0002] There are many GAP production bases in my country for the cultivation of rhubarb, and there are raw material supply bases with rich varieties, high quality and low prices. Rhein has high pharmacological activity, and its extract has been reported to protect the liver and resist fibrosis. Some scholars have found that rhein has obvious hepatoprotective and anti-hepatic fibrosis effects, the main mechanism is anti-oxidation and anti-inflammatory effects, thereby protecting liver cells and preventing liver fibrosis. It also has a preventive effect on diabetes, and its mechanism of action is to change the gene expression profile of the kidney, protect endothelial cells, improve cell metabolism, lower blood sugar and lipids, improve insulin resistance, and increase sensitivity to insulin. [0003] On the other hand, th...

Claims

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Application Information

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IPC IPC(8): C07C66/02C07C51/16C07C51/42A61K36/708
Inventor 张德志丁镇
Owner GUANGDONG PHARMA UNIV
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