Adhesive for dermal patch and production process thereof

An adhesive, patch technology, applied in the direction of film/sheet adhesive, adhesive type, ester copolymer adhesive, etc.

Active Publication Date: 2007-04-18
RESONAC CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, very little literature has been found in the past considering the effect of acrylate-based polymers on the degree of crosslinking between polymers and aluminum compounds

Method used

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  • Adhesive for dermal patch and production process thereof
  • Adhesive for dermal patch and production process thereof
  • Adhesive for dermal patch and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] Charge acrylic acid, sodium acrylate, and water into a 2 L separable flask. The ratio of acrylic acid / sodium acrylate is 50 / 50 (molar ratio). Ammonium persulfate as a polymerization initiator, potassium hydrogensulfite as a polymerization accelerator, and sodium hypophosphite as a chain transfer agent were added thereto, and polymerization was performed at a polymerization initiation temperature of 20° C. for 10 hours. The obtained agar-like gel was minced, dehydrated with ethanol (water content in slices after ethanol dehydration: 35%), and dried by hot blowing at 210° C. under a nitrogen stream for a whole day.

[0159] β-Hydroxypropionic acid in the polymer was extracted with an aqueous acetonitrile solution, and quantitatively measured by HPLC. UV detection was performed at 218 nm at a column temperature of 40°C using a 0.1% phosphoric acid aqueous solution as an eluent and SHODEX KC-811 (manufactured by Showa Denko K.K.) as a column. As a result, β-hydroxypropion...

Embodiment 2

[0164] Charge sodium acrylate and water into a 2 L separable flask. Ammonium persulfate as a polymerization initiator, potassium hydrogensulfite as a polymerization accelerator, and sodium hypophosphite as a chain transfer agent were added thereto, and polymerization was performed at a polymerization initiation temperature of 10° C. for 15 hours. The resulting agar-like gel was minced and dried by hot blowing at 50°C for a whole day.

[0165] When the content of β-hydroxypropionic acid in the polymer was quantitatively measured in the same manner as above, it was 110 ppm.

Embodiment 3

[0170] Sodium acrylate-N-vinylacetamide copolymer was polymerized by aqueous phase polymerization (copolymerization ratio: sodium acrylate / N-vinylacetamide=40 / 60 mass ratio). The obtained agar-like gel (water content: 75%) was dried by heat blowing at 200° C. for a whole day and formed into a powder. The powder is then purified by supercritical fluid using gaseous carbon dioxide. Supercritical CO to be produced by Showa Tansan Co., LTD 2 An extraction unit (standard type) is used for purification. The concentration of β-hydroxypropionic acid before purification was 6700 ppm.

[0171] As process conditions, 100 g of polymer was charged into a 500 mL extractor and 1000 NL of gaseous carbon dioxide was passed through for 1 hour. Make it pass only once under the conditions of 40°C and 30MPa. Since the copolymer is a fine powder, gaseous carbon dioxide was passed above and below the extractor to suppress diffusion of the sample in the extractor during the pressure rise and the ...

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Abstract

The present invention provides an adhesive for a dermal patch comprising an acrylate-base polymer in which the repetitive unit is represented by the formulae (1), (2) and (3): wherein M represents NH4<> or an alkali metal, and X represents an unsaturated monomer unit other than the formulae (1) and (2), containing 5 mole or more of acrylic acid (salt) represented by the formula (1) as a monomer unit, in which the content of ss-hydroxypropionic acid (salt) is 5,000 ppm or less per solid content of the polymer and having a stable shape retainability, adhesion and percutaneous absorptivity of medicines; an production process thereof; and an adhesive composition for a dermal patch containing the adhesive for a dermal patch, an aluminum compound and water.

Description

[0001] Cross References to Related Applications [0002] This application is an application filed pursuant to 35 U.S.C. § 111(a), which required 35 U.S.C. § 119(e)(1) in May 2004 under 35 U.S.C. Priority to U.S. Provisional Application Serial No. 60 / 569,622 filed on the 11th. technical field [0003] The present invention relates to an adhesive for a skin patch comprising an acrylate-based polymer as a main component, such as a percutaneous absorption type preparation for external use and the like. More specifically, the present invention relates to an acrylate-based polymer whose physical properties such as adhesiveness (which is important as a skin patch) have less divergence and can ensure stable quality, and also relates to its preparation method. Background technique [0004] In general, aqueous-type skin patches such as plasters are formed by ionically cross-linking sodium polyacrylate, polyacrylic acid, acrylic acid-sodium acrylate copolymer, cross-linked polyacryli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J133/06A61K9/70A61L15/58A61L15/44C08F6/00C08F6/16C09J133/02
CPCA61K9/7061A61L15/58A61L24/06C08F6/16C08F6/28C09J133/02C08L33/00C09J7/385A61F13/00987C09J133/06C09J2433/00
Inventor 石井彻弥
Owner RESONAC CORPORATION
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