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Ubenimex dispersion tablet and its preparing method

A technology of ubenimex and dispersible tablets, which is applied in the direction of pill delivery, drug combination, antineoplastic drugs, etc., can solve the problems of low dissolution rate and dissolution amount, long disintegration time of capsules, and inconvenient medication, etc., to achieve Convenience to take, improved bioavailability, fast and sufficient absorption

Inactive Publication Date: 2007-04-11
宛六一 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The oral preparations of Ubenimex currently on the market include capsules. Ubenimex is odorless, bitter in taste, and slightly soluble in water. Due to the long disintegration time of the capsules, the dissolution rate and dissolution rate are relatively low, and the absorption is poor. The utilization is low; and the medication is not very convenient, especially for the elderly, children, bedridden patients and patients with dysphagia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Ubenimex 30g

[0019] 240g pregelatinized starch

[0020] Lactose 120g

[0021] Sodium alginate 6g

[0022] Magnesium stearate 8g

[0023] Aspartame 4g

[0024] Pass Ubenimex through a 100-mesh sieve, and other excipients through a 80-mesh sieve, mix evenly, and directly compress into tablets.

Embodiment 2

[0026] Ubenimex 60g

[0027] Lactose 250g

[0028] Low-substituted hydroxypropyl cellulose 20g

[0029] Microcrystalline Cellulose 25g

[0030] Sodium Alginate 5g

[0031] Polyvinylpyrrolidone-K30 30g

[0032] Magnesium Stearate 10g

[0033] Mucilage 5g

[0034] Pass Ubenimex through a 100-mesh sieve, and other excipients through an 80-mesh sieve, mix Ubenimex, lactose, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and sodium alginate evenly, and use 10% polyethylene Pyrrolidone-K30 ethanol liquid granulation, drying, 20-mesh granulation, adding magnesium stearate, glue and tableting.

Embodiment 3

[0036] Ubenimex 100g

[0037] Cross-linked polyvinylpyrrolidone 600g

[0038] Sodium carboxymethyl starch 800g

[0039] Microcrystalline Cellulose 1000g

[0040] Agar 80g

[0041] Micronized silica gel 80g

[0042] Polyvinylpyrrolidone-K30 300g

[0043] Aspartame 60g

[0044] Pass Ubenimex through a 100-mesh sieve, and other auxiliary materials through an 80-mesh sieve, mix Ubenimex, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, and agar evenly, and prepare it with 12% polyvinylpyrrolidone-K30 ethanol liquid Granules, dried, granulated into 20 meshes, added with micropowder silica gel, sodium carboxymethyl starch, and aspartame for tableting.

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PUM

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Abstract

The invention relates to ubenimex disket and its process, a composition disket comprising such as active ubenimex, disintegrating agent, filler, suspending agent bond, glidant, corrigent. Said ubennimex disket is convenient for medication, suitable for the old and small children and patient with swallowing difficulties.

Description

technical field [0001] The invention relates to an antitumor drug ubenimex dispersible tablet and a preparation method thereof. Background technique [0002] Ubenimex (bestatin) is an aminopeptidase inhibitor isolated from the culture medium of Streptomyces olivine reticulum, which can interfere with the metabolism of tumor cells, inhibit the growth and metastasis of tumor cells, and improve the immune function of human cells. Stimulate the production and secretion of cytokines, promote the production and proliferation of anti-tumor effector cells. It can be used as an adjuvant therapy for anti-tumor chemotherapy and radiotherapy, and for senile immunodeficiency. It can also be used in combination with acute and chronic myeloid leukemia, multiple myeloma, myelodysplastic syndrome, simple red blood cell aplasia, and other solid tumors. . [0003] The oral preparations of Ubenimex currently on the market include capsules. Ubenimex is odorless, bitter in taste, and slightly s...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/198A61P35/00
Inventor 宛六一
Owner 宛六一
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