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Photo-sensitive stent with restricture-proof function

A restenosis, photosensitive technology, applied in the field of biomedical engineering, which can solve problems such as limited laser penetration depth

Inactive Publication Date: 2007-03-28
许川山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited penetration depth of laser in tissue, PDT has great limitations in tumor treatment

Method used

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  • Photo-sensitive stent with restricture-proof function
  • Photo-sensitive stent with restricture-proof function
  • Photo-sensitive stent with restricture-proof function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Observe the high-intensity focused ultrasound sensitization effect of photosensitizers on cultured cells in vitro: culture target cells: select vascular smooth muscle cells, and routinely culture them with DMEM culture medium containing 10% calf serum at 37°C containing 5% carbon dioxide, in an incubator saturated with water vapor; then, take target cells in the logarithmic growth phase (2×10 4 ) cells, add a photosensitizer such as hematoporphyrin, and incubate for 12 to 16 hours in an incubator containing 5% carbon dioxide and saturated water vapor at 37°C, because some photosensitizer hematoporphyrin may not be phagocytized by the target cells, and it is still free in the culture Therefore, before light irradiation, wash several times to remove the residual hematoporphyrin in the culture medium; then, apply a laser (He-Ne laser, its wavelength is 632.8nm, the output power is 0mW-100mW continuously adjustable, and the optical fiber is continuous output) to ...

Embodiment 2

[0021] Example 2: Pour the photosensitizer aloe-emodin into absolute ethanol, mix well and then filter and ultrasonically exhaust to make an aloe-emodin solution; then, take out a body lumen bracket and place it in the aloe-emodin solution , take it out after dipping for 10 seconds to 4 hours; dry it with nitrogen; repeat the above steps 1-3 times, and finally dry it with nitrogen to obtain a photosensitive stent as shown in Figure 4.

[0022] In this Example 2, the selected photosensitizer is a safe and non-toxic photosensitizer that can be selectively located in proliferative tissue cells. In addition to aloe-emodin, it can also be aluminum phthalocyanine, 5-aminoacetyl acetyl acid, hypocretin derivatives, monoasparagine chlorin, dexaphenanthium lutetium, rose bengal, hematoporphyrin, or hematoporphyrin monomethyl ether, etc.

Embodiment 3

[0023] Example 3: Add the photosensitizer aluminum phthalocyanine into polyamine acid (polyamine acid) and stir well, then apply the obtained liquid on the surface of the endoluminal tube stent; dry it naturally or blow it dry with nitrogen; the obtained solution is shown in Figure 4 The photosensitive scaffold shown.

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Abstract

The present invention belongs to the field of biomedical engineering, in the concrete, it relates to a photosensitive scaffold with the function of preventing and curing restenosis. The photosensitizer can be used to modify the scaffold so as to obtain photosensitive scaffold, said photosensitive scaffold is placed in the pathological lumen, and irradiated by light, so that the photosensitizer on the scaffold can be activated so as to produce photochemical reaction to form active oxygen substance, resist endometrial hyperplasia / and prevent production of scaffold restricture.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and more specifically, the invention relates to a photosensitive stent with the function of preventing restenosis. Background technique [0002] Endovascular stent implantation is an interventional treatment technology developed on the basis of endovascular angioplasty, and it has been widely used clinically. In the United States alone, there are nearly 100,000 cases of endovascular stent implantation a year. With the accumulation of clinical follow-up data, the postoperative restenosis rate is as high as 30-50%. Reducing restenosis after endovascular stent implantation is a clinical problem to be solved urgently. [0003] In recent years, with the rapid development of cell biology and molecular biology, some progress has been made in the research on the mechanism of restenosis after endoplasty. Studies have shown that early elastic recoil, vascular remodeling and stent-induced n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/40A61L31/12A61L31/16A61F2/82
Inventor 许川山王志刚
Owner 许川山
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