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Lysimachia herb total flavone extract and its prepn process

A technology of total flavonoids and desmodium, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of poor curative effect and low content of effective parts, and achieve the effects of inhibiting writhing reaction, increasing bile flow, and increasing urine output

Inactive Publication Date: 2007-03-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the traditional medication habits of traditional Chinese medicine, decoction is generally used when Desmodium is used as a medicine. The disadvantage is that the content of the effective parts is low and the curative effect is poor. Due to the limitation of the preparation technology, there is no total flavonoids extracted from Desmodium. Gao's products come out, but there is no report about them

Method used

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  • Lysimachia herb total flavone extract and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of Total Flavonoids of Desmodium

[0019] Take 10 kg of Desmodium herb medicinal material, reflux extraction with 10 times the amount of 50% ethanol solution for 3 times, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, centrifuge, absorb the supernatant on a D101 macroporous resin column, and use 80L of water, 60L of 10% ethanol, and 80L of 70% ethanol were eluted until the effluent was colorless, and the 70% ethanol eluate was collected and evaporated to dryness under reduced pressure to obtain 230 grams of total flavonoids extract of Desmodium chinensis, with a content of 65%.

Embodiment 2

[0021] Choleretic, diuretic, anti-inflammatory and analgesic effects of total flavonoids of Desmodium

[0022] 1. Test materials

[0023] 1.1 Drugs and reagents

[0024] The medicine is the total flavonoids of desmodium prepared by the method of Example 1.

[0025] Dose conversion:

[0026] Dosage of herbal medicine: 15-60g crude drug / day / person, 0.25-1.0g crude drug / kg.

[0027] Rat dose: 1g / kg (human) x 6 times = 1.5g crude drug / kg. Therefore, the test drug is equivalent to 6g crude drug / kg extract powder 138mg extract powder / kg as low dose; extract extract powder equivalent to 12g crude drug / kg 276mg extract powder / kg as high dose.

[0028] Mice dose: 0.5g / kg (human) x 9 times = 4.5g crude drug / kg. Therefore test drug is equivalent to 2.0g crude drug / kg extract powder 46mg extract powder / kg as low dosage; Be equivalent to 4.0g crude drug / kg extract powder

[0029] Extract powder 92mg extract powder / kg as high dose.

[0030] Lidan Paishi Capsules (LP, Xi'an Zhaoxing P...

Embodiment 3

[0058] Desmodium total flavonoids tablet

[0059] Take 100 mg of total flavonoids of Desmodium desmodium prepared by the method in Example 1, mix with 100 mg of starch and 100 mg of dextrin, use an appropriate amount of 30% ethanol as a wetting agent to make a soft material, granulate in a conventional method, add an appropriate amount of magnesium stearate and mix to prepare tablet.

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Abstract

The present invention relates to Chinese medicine technology, and discloses lysimachia herb total flavone extract and its preparation process. Lysimachia herb is treated through ethanol reflux extraction, centrifuging, eluting on macroporous resin and other steps to obtain the extract with lysimachia herb total flavone content of 30-80 %. The flavone compounds in the extract are analyzed in fingerprint to determine 32 common peaks. Pharmaceutical experiment shows that the effective lysimachia herb part extract possesses the functions of benefiting gall bladder, removing calculus, promoting urination, diminishing inflammation, relieving pain, etc, and may be used as the active component for calculus treating medicine and produced into different pharmaceutically acceptable preparations.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine. It relates to the effective part extract of Desmodium syringae-total flavonoids extract of Desmodium sativa and its preparation method. Background technique [0002] In recent years, the incidence of gallstones and urinary calculi has increased by as much as 10%, seriously affecting human health. At present, the drugs for the treatment of the disease in the world include mixed bile acids, chenodeoxycholic acid, ursodeoxycholic acid, menthol, menthone and other cyclic monoterpene mixtures. Studies have shown that bile acids are formed under the action of intestinal bacteria. The hepatocholic acid has hepatotoxicity, and long-term administration has the potential to cause atherosclerotic lipid metabolism changes. The current stone-dissolving drug treatment is not ideal, the reasons are: oral stone-dissolving treatment is long, the cost is high, the curative effect is not good...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P1/16A61P7/10A61P13/04A61P29/00
Inventor 孙启时王宇杰贾凌云袁久志
Owner SHENYANG PHARMA UNIVERSITY
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