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Injectio for nanometer total cambogic acid and its preparing method

A technology for injection preparations and gambogic acid, which is applied in the field of nano total gambogic acid injection preparations and its preparation, can solve the problems of unretrieved materials on the preparation method of nano total gambogic acid injection preparations, difficulties in drug efficacy stability of nanoparticles, nano Problems such as toxic and side effects of traditional Chinese medicine, to achieve the effect of easy large-scale industrial production, improve swelling, and anti-cancer

Inactive Publication Date: 2007-02-07
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, the toxic and side effects of nano-Chinese medicine: when the drug is made into nanoparticles, its physical and chemical properties have undergone significant changes. There is no relevant research report on whether these changes have toxic and side effects on the human body
Third, after the Chinese medicine is crushed at the nanoscale, the surface area of ​​the nanoparticles becomes larger. Due to the activity of the surface of the nanoparticles, they are easily agglomerated together, which brings great difficulties to the collection of the nanoparticles and the stability of their drug effects.
Fourth, the cost increases: due to the limitations of the existing technical level and equipment, the cost of preparing nano-Chinese medicine is much higher than that of traditional Chinese medicine.
[0006] After reviewing the literature and patents, no information on the nanometer total gambogic acid injection preparation and its preparation method was found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] (1) Extraction of total gambogic acid

[0105] Take 3 kg of gamboge and pulverize it, soak it overnight with the same volume of acetone, combine the acetone liquid, evaporate to dryness under reduced pressure to obtain a jelly, add a small amount of pyridine to dissolve it, add water, wash the solid with petroleum ether and pyridine, and obtain pyridine gambogic acid salt, the pyridinium salt was dissolved in ether, washed with hydrochloric acid, the ether layer was dried with anhydrous sodium sulfate, and the ether was evaporated to obtain total gambogic acid;

[0106] (2) The prescription consists of: total gambogic acid 5g, medicinal carrier 30g;

[0107] (3) carrier preparation method

[0108] Weigh 10g of soybean lecithin, 2g of poloxamer, and 802g of Tween, add it into distilled water at 75°C under high-speed stirring conditions, wait until it is completely melted as the water phase, then weigh 20g of trimyristin and add it to the total vine Heat and melt 5g of ...

Embodiment 2

[0115] (1) The prescription consists of: total gambogic acid 10g, medicinal carrier 50g;

[0116] (2) carrier preparation method

[0117] Weigh 20g of egg yolk lecithin, 5g of poloxamer, and 805g of Tween, add it into distilled water at 80°C under high-speed stirring conditions, wait until it is completely melted as the water phase, then weigh 30g of tristearin and add it to the total vine In 10g of xanthic acid, heat and melt as the oil phase, slowly add the oil phase to the water phase, continue to stir for 1 hour, and then ultrasonically disperse: room temperature, frequency 45-50Hz, ultrasonic time 5-8 minutes, to obtain a clear main drug suspension .

[0118] (3) preparation preparation:

[0119] Preparation of aqueous injection preparation: take the above suspension, add PVP 2g, add water for injection to 1000ml, stir well, adjust the pH value to 6.5-7.5, filter with a 0.22 μm microporous membrane, and sterilize to prepare the nano aggregate of the present invention. ...

Embodiment 3

[0124] (1) The prescription consists of: total gambogic acid 5g, medicinal carrier 30g;

[0125] (2) carrier preparation method

[0126] Weigh 15g of phosphatidylcholine, 3g of poloxamer, and 803g of Tween, add it into distilled water at 70°C under high-speed stirring conditions, wait until it is completely melted as the water phase, then weigh 15g of stearic acid and add it to the total gambogic acid 5g, heat and melt as the oil phase, slowly add the oil phase to the water phase, continue to stir for 1 hour and then ultrasonically disperse: room temperature, frequency 45-50Hz, ultrasonic time 5-8 minutes, to obtain a clear main drug suspension.

[0127] (3) preparation preparation:

[0128] Preparation of aqueous injection preparation: take the above suspension, add PVP 2g, add water for injection to 1000ml, stir well, adjust the pH value to 6.5-7.5, filter with a 0.22 μm microporous membrane, and sterilize to prepare the nano aggregate of the present invention. Gambogic ac...

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PUM

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Abstract

The invention discloses a nanometer cambogic acid injecting agent and preparing method, which is characterized by the following: adopting cambogic acid and superior drug carrier to prepare nanometer drug into water injection, powder injection and transfusion agent; improving the stability of dissolving property, physicochemical property and drug-carrying quantity effectively; modifying safety; reducing stimulation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a nano total gambogic acid injection preparation and a preparation method thereof. Background technique [0002] Nano Chinese medicine mainly refers to the active ingredients, active parts, original medicines and compound preparations of traditional Chinese medicines with a particle size of less than 100 nanometers manufactured by nanotechnology. The absorption and metabolism of drugs by biological organisms is a complex process. The pharmacological effects of traditional Chinese medicine preparations cannot be attributed to the unique chemical composition of the drug but are also closely related to the physical state of the preparation. Therefore, changing the physical state of pharmaceutical preparations is an effective method for the development of new drugs. Changing the unit size of a drug is very effective in changing the physical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/10A61P17/02A61P7/04A61P7/10
Inventor 张晴龙
Owner 张晴龙
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