Production of tolyl-triazone

Abstract

Production of tolyl triazone is carried out by synthesizing 3-methyl-4-(4-methylthio-trifluoride) phenoxy phenyl-hydrazine acid ester, preparing 1(N)-acetyl-2(N)-methyl-3(N)-(3-methyl-4-(4- methylthio-trifluoride)phenoxy) phenyl-triuret, preparing 1(N)-methyl-3(N)-hydrogen-5(N)-(3-methyl-4-(4- methylthio-trifluoride)phenoxy) phenyl-1,3,5-triazine-2,4,6-triketone and purifying crude product. It has better content and purity, more yields and no environmental pollution.

Description

Background technique: [0001] Xylazinone, generic name: Toltrazuril. [0002] Its molecular formula is: [0003] [0004] Its physical and chemical properties: white, crystalline powder, melting point 192°C-194°C, soluble in hot toluene and methanol, insoluble in water, weakly alkaline. [0005] Main application: used to treat poultry coccidiosis infection, this product can kill poultry coccidia in all stages of growth without affecting the generation of immunity. [0006] The current preparation process route is as follows: [0007] [0008] There is following shortcoming in this preparation method: [0009] 1. The water content in methyl urea is strictly controlled, and the production is very unstable. [0010] 2. Biuret is a two-component mixture, which cannot be purified, resulting in poor quality of the final product; [0011] 3. The yield of the product is relatively low, and the total yield is about 80%; [0012] 4. The toxicity of phosgene is extremely stron...

AI Technical Summary

Problems solved by technology

[0009] 1. Moisture control in methyl urea is very strict, and the production is very unstable

[0010] 2. Biuret is a two-component mixture, which cannot be purified, resulting in poor quality of the final product;

[0011] 3. The yield of the product is relatively low, and the total yield is about 80%;

[0012] 4. The toxicity of phosgene is extremely strong, which is extremely harmful to the production and operation workers

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