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Hydrophilic gel pleximetric paste and its preparation

A hydrophilic gel and transdermal patch technology, applied in the field of medicine, can solve the problems of complex ingredients, easy sensitization, and low content of active ingredients.

Active Publication Date: 2007-01-17
湖北兵兵药业(集团)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the hydrophilic gel transdermal patch developed by the existing technology has complex components and low content of active ingredients. Some products have certain irritation, are prone to sensitization, and are easy to fall off.
[0004] Bupleurum volatile oil is the volatile oil extracted from Bupleurum chinensis, a traditional Chinese medicine that has been widely used clinically. The main component of Bupleurum bupleurum injection used clinically is volatile oil. Influenza, malaria and other fevers are indeed curative (National Medicine Zhunzi Z41020926), and the application of Bupleurum volatile oil to the hydrophilic gel transdermal patch has not been seen so far.

Method used

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Examples

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Effect test

preparation example Construction

[0054] The preparation method of concrete implementation is:

[0055] Uniformly disperse the hydrophilic gel, adhesive, Bupleurum volatile oil, surfactant, penetration enhancer, and filler in the humectant to form A phase under stirring conditions, and uniformly disperse the crosslinking agent in the solvent under stirring conditions Form B phase in a certain vacuum condition, then stir B phase evenly and disperse in A phase under certain vacuum conditions to form a gel layer, then apply the gel layer on the non-woven fabric, cover it with a protective film, and cut it to a certain specification. Hydrophilic gel patch containing bupleurum volatile oil was produced by curing at room temperature.

Embodiment 1

[0057] The formula is as follows:

[0058] (Bupleurum volatile oil) Bupleurum volatile oil 1.0%

[0059] (Penetration enhancer) Oleic acid 4.0%, Azone 3.0%, PEG 4.0%

[0060] (Surfactant) Tween 1.0%

[0061] (Binder) Gelatin 1.0%

[0062] (Moisturizer) Propylene Glycol 5.0% Glycerin 24%

[0063] (hydrophilic gel) sodium polyacrylate 4.0%

[0064] (Solvent) Water 53.0%

[0065] The preparation method is: sodium polyacrylate, gelatin, Bupleurum volatile oil, Tween, oleic acid, azone, and PEG are uniformly dispersed in propylene glycol and glycerin (phase A) under stirring conditions, the solvent water is phase B, and then the phase B The phase is stirred and evenly dispersed in phase A under a certain vacuum condition to form a gel layer, and then the gel layer is coated on a non-woven fabric, covered with a protective film, cut to a certain specification, and cured at room temperature to produce a product containing diesel Hydrophilic gel patch with essential oils.

Embodiment 2

[0067] (Bupleurum volatile oil) Bupleurum volatile oil 5.0%

[0068] (Penetration enhancer) Oleic acid 1.0%, Azone 3.0%, PEG 1.0%

[0069] (Surfactant) Tween 2.0%

[0070] (Binder) Gelatin 1.0%

[0071] (Moisturizer) Propylene Glycol 5.0% Glycerin 25%

[0072] (hydrophilic gel) sodium polyacrylate 4.0%

[0073] (Solvent) Water 53%

[0074] Preparation method is the same as embodiment 1

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Abstract

A percutaneous paster of hydrophilic gel for medicine features that its gel layer contains the volatile oil of bupleurum root, hydrophilic gel, cross-linking agent, humectant, surfactant, filler, adhesive, osmosis promoter and solvent. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a hydrophilic gel transdermal patch for drug transdermal controlled release treatment and a preparation method thereof. Background technique [0002] Hydrophilic gel transdermal patch (Babu plaster) is an external patch made of water-soluble polymer compound or hydrophilic substance, mixed with medicine or Chinese medicine extract, and coated on non-woven fabric piece. It has good biocompatibility, affinity, breathability, sweat resistance and repeated peeling and tearing properties to the skin, and is not easy to be allergic. In the early 1970s, Japan, Europe and other countries began to develop medical cataplasms. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. According to the prediction of the World Health Organization, in the next few years, more than 30% of the drugs will be changed to tran...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/70A61K9/00A61K47/42A61K47/32A61K47/46A61P29/00
Inventor 曾婕王海波
Owner 湖北兵兵药业(集团)有限公司
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