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Medicinal composition containing rosuvastatin or pitavastatin and B clan vitamin

A technology of rosuvastatin and pitavastatin, which is applied in the field of preparation of medicines, to achieve the effects of improving curative effect, taking medicine conveniently, and not increasing toxicity

Active Publication Date: 2007-01-10
SHENZHEN AUSA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the 9-30% reduction in total mortality and the 24-37% reduction in coronary events, the prevention and treatment strategies for coronary heart disease still need to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Rosuvastatin Folic Acid Tablets

[0027] Prescription: Rosuvastatin Calcium 10g

[0028] Folic acid 0.4g

[0029] Lactose 50g

[0030] Starch 50g

[0031]Sodium carboxymethyl starch 20g

[0032] 10% starch slurry appropriate amount

[0033] Magnesium Stearate Appropriate amount

[0034] Preparation method: crush the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amount of rosuvastatin calcium, folic acid, lactose, starch and carboxymethyl starch sodium, crush and sieve, mix evenly, and make it with an appropriate amount of 10% starch slurry Soft material, granulated, dried at 40°C to 60°C until the moisture content is about 3%, taken out, sized, mixed evenly with an appropriate amount of magnesium stearate, pressed into 1000 tablets according to conventional methods.

Embodiment 2

[0035] Example 2 Preparation of Rosuvastatin Folic Acid Tablets

[0036] Prescription: Rosuvastatin Calcium 20g

[0037] Folic acid 0.8g

[0038] Microcrystalline Cellulose 60g

[0039] 40g pregelatinized starch

[0040] Micropowder silica gel amount

[0041] Magnesium Stearate Appropriate amount

[0042] Preparation method: crush the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amount of rosuvastatin calcium, folic acid, microcrystalline cellulose, pregelatinized starch, micropowder silica gel and magnesium stearate, mix evenly, and press the powder directly into 1000 tablets are available.

Embodiment 3

[0043] Example 3 Preparation of Rosuvastatin Folic Acid Capsules

[0044] Prescription: Rosuvastatin Calcium 40g

[0045] Calcium Leucovorin 5g

[0046] Microcrystalline Cellulose 50g

[0047] Starch 50g

[0048] PVP 20g

[0049] 10% starch slurry appropriate amount

[0050] Micropowder silica gel amount

[0051] Preparation method: crush the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amount of rosuvastatin calcium, leucovorin calcium, lactose starch and PVP, crush and sieve, mix evenly, and make it with an appropriate amount of 10% starch slurry Soft material, granulated, dried at 40°C to 60°C until the water content is about 3%, taken out, sized, mixed evenly with an appropriate amount of talcum powder, and filled with 1000 capsules according to the conventional method.

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PUM

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Abstract

The present invention relates to a medicine composition conlaining resulvatatine or pivatatine compound and vitamins B, in which the resulvatatine or pivatatine content is 1-40 mg and vitamins B content is 0.1-50 mg. Said invention also provides the application of said medicine composition in preparation of medicine for preventing and curing the diseases of atherosclerosis, angiocardiopathy and cerebrovascular disease.

Description

technical field [0001] The invention provides a pharmaceutical composition containing rosuvastatin or pitavastatin and B vitamins, and the application of the pharmaceutical composition in preparing medicine. belongs to the field of pharmacy. Background technique [0002] Cardiovascular diseases are the first or second cause of death in my country, and the incidence and mortality of coronary heart disease are on the rise. Several risk factors such as hyperlipidemia, hypertension, smoking and diabetes play an important role in the pathogenesis of coronary heart disease. Among them, hypercholesterolemia can cause and accelerate atherosclerosis. As one of the main risk factors of coronary heart disease, it has already attracted extensive attention. Epidemiological studies have confirmed that the increase in total cholesterol level is positively correlated with the risk of death from coronary heart disease; the prevalence of coronary heart disease in patients with cholesterol &...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61K31/714A61K31/519A61K9/16A61K9/20A61K9/48A61P9/10A61K31/47
Inventor 陈光亮王琳琳
Owner SHENZHEN AUSA PHARM CO LTD
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