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In vitro molecular adsorption and circulation system

A circulatory system and molecular adsorption technology, applied in dialysis systems, blood circulation treatment, suction equipment, etc., can solve the problems of low rupture rate of simulated membrane, high membrane separation rate of simulated membrane, etc., to shorten treatment time, The effect of reducing the rate of membrane rupture and relieving pain

Inactive Publication Date: 2006-12-20
缪志俊 +4
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AI Technical Summary

Problems solved by technology

[0019] In order to overcome the shortcomings of the high membrane rupture rate and unreasonable definition of membrane separability of the simulated membrane used in the extracorporeal artificial liver support system in the prior art, the present invention provides a simulated membrane with a low membrane rupture rate and a reasonable range of membrane separability Extracorporeal Artificial Liver Support System with Good Separation Performance of Endotoxin and Toxin

Method used

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  • In vitro molecular adsorption and circulation system
  • In vitro molecular adsorption and circulation system
  • In vitro molecular adsorption and circulation system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] refer to figure 1 , an extracorporeal molecular adsorption circulatory system, used as an extracorporeal artificial liver support system, including an extracorporeal blood circulation line, an albumin solution circulation line, human blood is circulating in the extracorporeal blood circulation line, and prepared in the albumin solution circulation line The dialysate albumin is circulating;

[0048] Arterial output terminal, blood pump 1, arterial jug 2, intelligent dialyzer 3, venous jug 4, bubble monitor 5 and venous input end are arranged in sequence on the extracorporeal blood circulation pipeline, and the intelligent dialyzer 3 is provided with There is a simulated membrane selective to protein-bound toxins and water-soluble toxins, and the simulated membrane separates the intelligent dialyzer 3 into an extracorporeal blood circulation circuit side and an albumin solution circulation circuit side. The intelligent dialyzer 3 described here is a high-throughput dialy...

Embodiment 2

[0086] refer to Figure 7 , an extracorporeal artificial liver support system, comprising an extracorporeal blood circulation circuit and an albumin solution circulation circuit;

[0087] A blood pump 1, an arterial jug 2, an intelligent dialyzer 3, a venous jug 4, and a bubble monitor 5 are sequentially arranged on the extracorporeal blood circulation pipeline, and the intelligent dialyzer 2 is provided with a protein-binding toxin and a water-soluble The toxin has a selective simulated membrane, and the simulated membrane separates the intelligent dialyzer 3 into an extracorporeal blood circulation circuit side and an albumin solution circulation circuit side, and the intelligent dialyzer 3 described here is a high-throughput Dialyzer, the simulated membrane is a selective semi-permeable membrane;

[0088] A blood leakage monitor 6, an albumin solution pump 7, a defoamer 8, and a toxin adsorber are sequentially arranged on the albumin liquid circulation pipeline. The toxin ...

Embodiment 3

[0096] The structural parameters of the simulated membrane are as follows: Membrane wall thickness: 25 μm, total membrane surface area: 2.1m 2 , the pore size of the pores on the membrane: molecules with a molecular weight of 62000 Daltons are allowed to pass through.

[0097] In this embodiment, the length of a single hollow fiber membrane is 30 cm, the inner diameter of a single hollow fiber membrane is 200 μm, and the outer diameter of a membrane is 250 μm, so that the circumference of a single hollow fiber membrane is 0.000785 m. The surface area of ​​the root hollow fiber membrane is 0.000236m 2 , in order to achieve a total surface area of ​​2.1m 2 , this embodiment requires 8912 hollow fiber membranes.

[0098] refer to Figure 13-17 , under the same experimental conditions, when the smart dialyzer adopts HF 80 from Fresenius Company, the effect is obviously inferior to that of the extracorporeal artificial liver support system described in this example: by Figure ...

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Abstract

The invention relates to an external molecule adsorption cycle system, which comprises an external blood cycle tube, and an albumin liquid cycle tube, wherein the first tube comprises a blood pump and an intelligent adialyser; the intelligent dialyser is arranged with the analogue film with the selectivity on the protein combine toxin and the soluble toxin; the analogue film is the hollow fiber film whose wall thickness is 10-30micrometers, the total surface is 2.1-2.4m2, and the aperture of the hole on the film can allow passing the molecule whose molecule weight is less than 60000-66000. The invention has the advantages that: 1, the wall thickness is controlled, to reduce the broken rate; 2, the aperture is controlled to reduce the treat time; 3, the dosage of anticoagulant is reduced to avoid leaking blood; 4, the surface is controlled by reasonable math model with high film separate property.

Description

(1) Technical field [0001] The invention relates to a medical device, an extracorporeal molecular adsorption circulatory system, in particular to an extracorporeal artificial liver support system capable of simultaneously removing protein-bound toxins and water-soluble toxins, and temporarily replacing human liver functions. (2) Background technology [0002] In liver failure, a large amount of protein-bound toxins and water-soluble toxins accumulate in the patient's blood due to insufficient liver detoxification function. Water-soluble toxins can be separated by the current medical separation technology, but the protein-bound toxins bound by ligands cannot be removed selectively and effectively by the usual blood purification methods. [0003] Clinical data prove that protein-bound toxins can trigger a variety of endogenous and exogenous toxic reactions in the human body. Therefore, it is imminent to develop an artificial liver support system that can simultaneously remove ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/00A61M1/14A61M1/36A61M1/38
Inventor 缪志俊陈缤烨陈岭俞伊娜李丹
Owner 缪志俊
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