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Soluble compound medicinal preparation of antibacterial drugs, and preparation method

A technology of antibacterial drugs and pharmaceutical preparations, applied in the field of medicine

Inactive Publication Date: 2006-12-06
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since 2002, although pharmaceutical companies have promoted it again, they still encounter the same problem in clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Under GMP conditions, this antibacterial combination pharmaceutical preparation is fully mixed with 100 grams of sterile furbenicillin sodium with a particle size of 100 mesh and 1 g of sterile L-arginine with a particle size of 200 mesh, according to the powder injection preparation process Program operation, packaged into 400 pieces;

Embodiment 2

[0044] Embodiment 2: Under GMP conditions, the antibacterial combination pharmaceutical preparation is fully mixed by 200 grams of 100-mesh sterile furbenicillin sodium and 100-mesh sterile L-arginine 1 g, operated according to the powder injection preparation process procedure, and packed into 400 pieces;

Embodiment 3

[0045] Example 3: Under GMP conditions, the antibacterial combination pharmaceutical preparation is fully mixed with 100 grams of sterile furbenicillin sodium and 400 g of sterile L-arginine, and is packed into 400 sticks according to the powder injection preparation process procedure;

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PUM

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Abstract

An antibacterial composite medicine easy to dissolve is prepared from furbenicillin or its physiologically acceptable medicinal salt or hydrate, and the pharmacologically acceptable inorganic salt of water-soluble alkali metal or alkali-earth metal, organic alkali and organic acid or its salt. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to provide an easily soluble antibacterial combined drug preparation and a preparation method thereof. Background technique [0002] One of furbenicillin derivatives, furbenicillin (6-[D-α-(3-(2-furyl) urea) phenylacetamido] penicillin acid (Furbenicillin) is a broad-spectrum semi-synthetic urea Penicillin-like, with strong antibacterial activity, against hemolytic streptococcus, viridans streptococcus, meningococcus, pneumococcus, enterococcus, influenza bacillus, alcaligenes, Proteus mirabilis, typhoid bacillus, paratyphoid bacillus, green Gram-positive and negative bacteria such as Pseudomonas have broad-spectrum antibacterial activity and are highly active against Pseudomonas aeruginosa. [0003] Furabenicillin (Canadian patent Can.966853, British patent 1282742, and U.S. patent 3479339) was synthesized by the Bristol-Myer Company of the United States in...

Claims

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Application Information

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IPC IPC(8): A61K31/431A61K9/08A61K47/02A61K47/18A61K47/12A61P31/04
Inventor 刘力
Owner 刘力
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